Cancer and Metastasis Reviews

, Volume 25, Issue 3, pp 315–322 | Cite as

Role of tumor-associated macrophages in tumor progression and invasion

  • Alberto Mantovani
  • Tiziana Schioppa
  • Chiara Porta
  • Paola Allavena
  • Antonio Sica


Tumor-Associated Macrophages (TAM) represent the major inflammatory component of the stroma of many tumors, able to affect different aspects of the neoplastic tissue. Many observations indicate that TAM express several M2-associated protumoral functions, including promotion of angiogenesis, matrix remodelling and suppression of adaptive immunity. The protumoral role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage content of tumors and poor patient prognosis and by evidence showing that long-term use of non-steroidal anti-inflammatory drugs reduces the risk of several cancers. Here, we discuss evidence supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and a potential target of anti-cancer therapy.


Tumor-associated macrophages Tumor Inflammation NF-κB Metastasis Hypoxia 


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Copyright information

© Springer Science + Business Media, LLC 2006

Authors and Affiliations

  • Alberto Mantovani
    • 1
    • 2
  • Tiziana Schioppa
    • 3
  • Chiara Porta
    • 1
  • Paola Allavena
    • 1
  • Antonio Sica
    • 1
  1. 1.Istituto Clinico HumanitasRozzano, MilanItaly
  2. 2.Centro di Eccellenza per l’Innovazione Diagnostica e Terapeutica, Institute of PathologyState University of MilanMilanItaly
  3. 3.Istituto di Ricerche Farmacologiche Mario NegriMilanItaly

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