Left ventricular mechanical dyssynchrony assessment in obese patients using the cadmium-zinc telluride SPECT camera

  • Han Zhang
  • Xin Fan
  • Shanshan Qin
  • Jiajia Zhang
  • Yuzhen Yin
  • Mengdie Yang
  • Fei YuEmail author
Original Paper


The use of phase analysis techniques to assess left ventricular mechanical dyssynchrony (LVMD) has been well documented. However, artifacts have reduced the accuracy of the assessment due to soft tissue attenuation, so little information is available about the effects of obesity on LVMD. The aim of this study was to evaluate LVMD in patients with simple obesity by SPECT with a new cadmium-zinc telluride (CZT) detector and to explore the effects of obesity on left ventricular wall motion. We retrospectively analyzed 95 patients with myocardial perfusion imaging (MPI) images without perfusion defects, of which 55 were diagnosed with simple obesity (BMI > 30), and 40 non-obese patients (BMI < 25) matched for age and sex were used as controls. The five-point method was used to analyze the MPI images of the two groups, and the complete cardiac function parameters including phase bandwidth (PBW) and phase standard deviation (PSD) were obtained. Although the PBW values of the two groups were within the normal range (cut-off value > 90°), the PBW (35.4 ± 28 vs 24.9 ± 7.5, P < .001; 36.6 ± 18.4 vs 28.7 ± 9.1, P = 0.01) and PSD (8.7 ± 7.6 vs 5.9 ± 2, P = 0.02; 9.2 ± 4.9 vs 7.1 ± 2.7, P = 0.01) of the obese group were larger than the control group under both stressing and resting, and the difference was statistically significant. CZT-SPECT can effectively assess LVMD in obese patients, and they are more likely to develop LVMD, which may be related to their left ventricular volume.


Left ventricular mechanical dyssynchrony Phase analysis Phase standard deviation Phase bandwidth 



Left ventricular mechanical dyssynchrony


Cardiovascular diseases


Coronary artery disease


Myocardial perfusion imaging




Phase bandwidth


Phase standard deviation


Left ventricular ejction fraction


End systolic volume


End diastolic volume


Coronary angiography



Funding was provided by The National Key Research and Development Program Of China (Grant No. 2016YFC0104303).

Compliance with ethical standards

Conflict of interest

There is no potential conflict of interest to disclose.


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Copyright information

© Springer Nature B.V. 2020

Authors and Affiliations

  • Han Zhang
    • 1
  • Xin Fan
    • 1
  • Shanshan Qin
    • 1
  • Jiajia Zhang
    • 1
  • Yuzhen Yin
    • 1
  • Mengdie Yang
    • 1
  • Fei Yu
    • 1
    Email author
  1. 1.Department of Nuclear MedicineShanghai Tenth People’s Hospital of Tongji UniversityShanghaiPeople’s Republic of China

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