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Postsystolic shortening on echocardiography as a gateway to cardiac computed tomography in patients with suspected stable angina pectoris

  • Philip BraininEmail author
  • Flemming Javier Olsen
  • Mats Christian Højbjerg Lassen
  • Jan Bech
  • Brian Claggett
  • Thomas Fritz-Hansen
  • Fredrik Folke
  • Gunnar H. Gislason
  • Tor Biering-Sørensen
Original Paper

Abstract

Postsystolic shortening (PSS) by speckle-tracking echocardiography (STE) is a marker of myocardial ischemia and may improve diagnostic strategy. We sought to evaluate if PSS is associated with the coronary artery calcium score (CACS) and stenosis by computed tomography angiography (CTA) in patients with suspected stable angina pectoris (SAP). We retrospectively studied 437 SAP patients (age 58 ± 11 years, 41% male) who underwent STE, evaluation of CACS and assessment of significant stenosis (≥ 50%) by CTA. The postsystolic index (PSI) was defined as follows: 100x([peak negative strain cardiac cycle − peak negative strain systole])/peak negative strain cardiac cycle. A wall had PSS if any segment within the wall had a PSI ≥ 20%. We defined categories for walls with PSS: 0, 1, 2 and ≥ 3, and CACS: 0, 1–100, 101–400 and > 400. Each additional wall with PSS was associated with a 43% relative increase in CACS (95%CI +9% to +87%, P = 0.010), while each 1% absolute increase in the PSI was associated with a 9% relative increase in CACS (95%CI +1% to +18%, P = 0.031). Walls with PSS (OR 1.81 per 1 wall increase, 95%CI 1.27–2.59, P = 0.001) and the PSI (OR 1.12 per 1% increase, 95%CI 1.04–1.21, P = 0.004) were associated with the occurrence of CACS > 400. Additionally, walls with PSS (OR 1.53 per 1 wall increase, 95%CI 1.21–1.93, P < 0.001) was a predictor of significant stenosis by CTA. PSS is associated with CACS and significant stenosis by CTA in patients with SAP and may aid in the selection of patients referred for cardiac computed tomography.

Keywords

Stable angina Echocardiography Postsystolic shortening Coronary artery calcium 

Notes

Funding

PB received a research grant from the Gangsted Foundation and the Lundbeck Foundation. TBS was supported by the Fondsbørsvekselerer Henry Hansen og Hustrus Hovedlegat 2016. The sponsors had no role in the study design, data collection, data interpretation or writing of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors report no conflicts of interest.

Supplementary material

10554_2019_1724_MOESM1_ESM.docx (5.9 mb)
Supplementary material 1 (DOCX 6041 kb)

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Philip Brainin
    • 1
    Email author
  • Flemming Javier Olsen
    • 1
  • Mats Christian Højbjerg Lassen
    • 1
  • Jan Bech
    • 1
  • Brian Claggett
    • 2
  • Thomas Fritz-Hansen
    • 1
  • Fredrik Folke
    • 1
  • Gunnar H. Gislason
    • 1
  • Tor Biering-Sørensen
    • 1
  1. 1.Cardiovascular Non-Invasive Imaging Research Laboratory, Department of CardiologyHerlev and Gentofte University HospitalCopenhagenDenmark
  2. 2.Department of Cardiovascular Medicine, Cardiac Imaging Core LaboratoryBrigham and Women’s HospitalBostonUSA

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