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Quantification of intramyocardial hemorrhage volume using magnetic resonance imaging with three-dimensional T1-weighted sequence in patients with ischemia-reperfusion injury: a semi-automated image processing technique

  • Hideo Arai
  • Masateru KawakuboEmail author
  • Ko Abe
  • Hikaru Hatashima
  • Kenichi Sanui
  • Hiroshi Nishimura
  • Toshiaki Kadokami
Original Paper

Abstract

Although intramyocardial hemorrhage (IMH) is a poor prognostic factor caused by ischemia reperfusion injury, little evidence is available regarding the association between IMH volume and biomarkers. In the present study, we measured IMH volume using three-dimensional (3D) T1-weighted magnetic resonance imaging (T1-MRI) and investigated its association with biomarkers. Moreover, the accuracy of semi-automatic measurement of IMH volume was validated. We retrospectively enrolled 33 consecutive patients (mean age 67 ± 11 years) who underwent cardiac MRI after reperfusion therapy for acute myocardial infarction. IMH was observed in 4 patients (12.1%). Receiver operating characteristics (ROC) analysis of creatine kinase (CK) and CK-muscle/brain (CK-MB) tests for detecting IMH were performed. IMH volume measured using semi-automatic methods by a 2 standard deviation (SD) threshold was compared to manual measurements using the Spearman’s correlation coefficient (ρ) and Bland–Altman analyses. ROC analysis revealed optimal cutoff values of CK: 2460 IU/l and CK-MB: 231 IU/l (area under the curve: 0.95 and 0.91; sensitivity: 86% and 79%; specificity: 100% for both). IMH volume with the 2SD threshold correlated with that of the manual measurement [5.84 g (3.30 to 9.00) g vs. 8.07 g (5.37 to 9.33); ρ: 0.85, p < 0.01; bias (limit of agreement): − 0.01 g (− 0.51 to 0.49); intraclass correlation coefficients 0.84 (0.75 to 0.90)]. Our findings could help identify the risk of IMH after reperfusion therapy with biomarkers. 3D T1-MRI can semi-automatically provide accurate IMH volume without being time-consuming.

Keywords

Intramyocardial hemorrhage Biomarker Quantification Semi-automated threshold method Magnetic resonance imaging Acute myocardial infarction 

Notes

Acknowledgement

This work was supported by The Japanese Circulation Society (JCS) Grant for medical technologists in 2017.

Compliance with ethical standards

Conflict of interest

All the authors declares that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the institutional review board, and the requirement for patient consent was waived. An online provision, on the hospital homepage, was prospectively made available to the patients for opting out of the study.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Fukuokaken Saiseikai Futsukaichi HospitalFukuokaJapan
  2. 2.Department of Health Sciences, Faculty of Medical SciencesKyushu UniversityFukuokaJapan
  3. 3.Oita Prefectural HospitalOitaJapan

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