Multimodal imaging of a self-expanding transcatheter aortic valve replacement (TAVR) procedure in a reanimated human heart and post-implant analyses

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We acknowledge the gift of this human heart for research from the organ donor/donor family as well as LifeSource for their assistance in organ recovery. We further acknowledge Dr. Brian Bagley and the X-ray Computed Tomography Laboratory in the Department of Earth Sciences, University of Minnesota, for technical assistance in micro-CT imaging. This work was funded by the Institute for Engineering in Medicine at the University of Minnesota and a research contract with Medtronic. CoreValve Evolut™ R is an FDA-approved and market released product in the United States.

Author information

All authors contributed to the conception, design, and setup of this study. JDZS: Drafted manuscript, created TAVR video, prepared TAVR device and delivery system, imaged heart specimen, reconstruction and modeling, 3D printing. MGB: Edited manuscript and video, selected/implanted TAVR, imaged heart specimen, post-implant imaging analyses. PAI: Final revision and approval of manuscript and video, reanimated heart specimen, implanted TAVR, multimodal imaging of TAVR procedure.

Correspondence to Paul A. Iaizzo.

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Conflict of interest

PA Iaizzo has a research contract and education consultant arrangement with Medtronic. MG Bateman has ownership interest in Medtronic. JD Zhingre Sanchez has no conflicts of interest to declare.

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This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

LifeSource secured consent from the organ donor’s family to use this heart for research.

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Zhingre Sanchez, J.D., Bateman, M.G. & Iaizzo, P.A. Multimodal imaging of a self-expanding transcatheter aortic valve replacement (TAVR) procedure in a reanimated human heart and post-implant analyses. Int J Cardiovasc Imaging 35, 2135–2137 (2019).

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