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The prognostic value of ultra low-dose thallium myocardial perfusion protocol using CZT SPECT

  • Veronika Bednárová
  • Vladimír KinclEmail author
  • Milan Kamínek
  • Jiří Vašina
  • Roman Panovský
  • Jan Máchal
Original Paper
  • 20 Downloads

Abstract

The purpose of this study was to assess the prognostic value of ultra-low dose thallium myocardial perfusion imaging. Three hundred and sixty-six patients (245 men) underwent ultra-low dose stress-redistribution imaging on CZT SPECT camera GE Discovery NM 530c. The stress test was performed by bicycle ergometry or regadenoson injection. The activity of 0.5 MBq (0.014 mCi) Tl-201 chloride per kilogram of body weight was administered. The stress images were acquired immediately and redistribution images were taken after 3 h. Patient follow-up was focused on combined end-point (death, myocardial infarction, unstable angina, revascularization and hospitalization for heart failure). Data analysis was performed from hospital database, with a mean period 23 months. Patients with revascularization within 1 month after SPECT was excluded as revascularization for diagnosis. Ischaemia on SPECT was found in 72 patients, 294 patients were without ischaemia. In patients with ischaemia there were 21 (29.2%) subjects with cardiac events, and 23 (7.9%) in patients without ischaemia (HR 4.15, 95% CI 2.30–7.51, p < 0.0001). Ultra-low dose thallium perfusion imaging using CZT camera provides very good prognostic results in assessment of myocardial ischaemia.

Keywords

Myocardial perfusion Thallium Low-dose CZT SPECT Prognostic value 

Notes

Acknowledgements

This study was supported by the project no. LQ1605 from the National Program of Sustainability II (MEYS CR).

Compliance with ethical standards

Conflict of interest

All authors declare none conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of Internal Medicine/CardiologySt. Ann’s University Hospital, Masaryk UniversityBrnoCzech Republic
  2. 2.International Clinical Research CenterSt. Ann’s University HospitalBrnoCzech Republic
  3. 3.Department of Nuclear MedicineUniversity Hospital Olomouc, Palacky UniversityOlomoucCzech Republic
  4. 4.Department of Nuclear MedicineMasaryk Memorial Cancer CenterBrnoCzech Republic
  5. 5.Department of Pathological Physiology, Faculty of MedicineMasaryk UniversityBrnoCzech Republic

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