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Anthracycline induced inconsistent left ventricular segmental systolic function variation in patients with lymphoma detected by three-dimensional speckle tracking imaging

  • Yuchen Xu
  • Jing Shi
  • Rui Zhao
  • Chujie Zhang
  • Yiyao He
  • Jinyi Lin
  • Qunling Zhang
  • Xianhong Shu
  • Leilei ChengEmail author
Original Paper

Abstract

Chemotherapy contained anthracycline inevitably cause declines of cardiac function. This study evaluated the deterioration of left ventricular segmental systolic function in patients with lymphoma received anthracycline chemotherapy detected by echocardiographic three dimensional speckle tracking imaging (3D-STI). Sixty patients with newly diagnosed diffuse large B-cell lymphoma who received R-CHOP chemotherapy were enrolled. Three dimensional left ventricular global longitudinal strain (3D-GLS), three dimensional left ventricular global circumferential strain (3D-GCS) and three dimensional left ventricular longitudinal strain of different left ventricular segments (3D-LS) were measured by 3D-STI at baseline, after the completion of two cycles and four cycles of the regimen respectively. Compared with baseline, 3D-GLS reduced significantly after four cycles of anthracycline therapy (P < 0.001), while 3D-GCS showed no significant variation during the whole procedure (all P > 0.05). For individual segment, LS of apical anterior and septal walls decreased significantly after two cycles of chemotherapy (all P < 0.05). After four cycles of treatment, 3D-LS of the mid-ventricular level (all P < 0.05), apical level (all P < 0.05) and apex (P < 0.05) worsened. Serum hs-cTnT levels increased after anthracycline exposure (P < 0.05) and Serum hs-cTnT levels were correlated with 3D-GLS at the end of four cycles (r = 0.12, P = 0.03). Mean values of involved segmental 3D-LS of two and four cycles were both correlated with serum hs-cTnT levels at the end of both two and four cycles (r = 0.368, P = 0.041; r = 0.79, p < 0.001). 3D-STI evaluation of the LV provides an understanding of the segmental impairment of LV wall and the possible process of LV impairment in lymphoma patients after anthracycline chemotherapy.

Keywords

Anthracycline Cardiotoxicity Left ventricular function Strain Echocardiography 

Notes

Funding

This study was supported by grant 2017BR027 from Municipal Human Resources Development Program for Outstanding Leaders in Medical Disciplines in Shanghai, grant 20164Y0076 from Shanghai Health and Family Planning Commission, 81771840 from National Natural Science Foundation of China.

Compliance with Ethical Standards

Conflict of interest

All authors declare no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Yuchen Xu
    • 1
    • 2
  • Jing Shi
    • 1
    • 2
  • Rui Zhao
    • 1
    • 2
  • Chujie Zhang
    • 1
    • 2
  • Yiyao He
    • 1
    • 2
  • Jinyi Lin
    • 3
  • Qunling Zhang
    • 4
  • Xianhong Shu
    • 1
    • 2
  • Leilei Cheng
    • 1
    • 2
    Email author
  1. 1.Department of Echocardiography, Zhongshan HospitalFudan UniversityShanghaiChina
  2. 2.Shanghai Institute of Cardiovascular Diseases, Shanghai Institute of Medical ImagingFudan UniversityShanghaiChina
  3. 3.Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular DiseasesFudan UniversityShanghaiChina
  4. 4.Department of Medical OncologyFudan University Shanghai Cancer CenterShanghaiChina

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