3.0-T whole-heart coronary magnetic resonance angiography: comparison of gadobenate dimeglumine and gadofosveset trisodium

  • Fabio S. Raman
  • Marcelo S. Nacif
  • George Cater
  • Neville Gai
  • Jacquin Jones
  • Debiao Li
  • Christopher T. Sibley
  • Songtao Liu
  • David A. Bluemke
Original paper


Gadolinium enhanced coronary magnetic resonance angiography (MRA) at 3 T appears to be superior to non-contrast methods. Gadofosveset is an intravascular contrast agent that may be well suited to this application. The purpose of this study was to perform an intra-individual comparison of gadofosveset and gadobenate for coronary MRA at 3 T. In this prospective randomized study, 22 study subjects [8 (36 %) male; 27.9 ± 6 years; BMI = 22.8 ± 2 kg/m2] underwent two studies using a contrast-enhanced inversion recovery three-dimensional fast low angle shot MRA at 3 T. The order of contrast agent administration was varied randomly, separated by an average of 30 ± 5 days, using either gadobenate dimeglumine (Gd-BOPTA; Bracco, 0.1 mmol/Kg) or gadofosveset trisodium (MS-325; Lantheus Med, 0.03 mmol/Kg). Acquisition time, signal-to-noise ratio (SNR) of coronary vessels and contrast-to-noise ratio (CNR) were evaluated. Of 308 coronary arteries and veins segment analyzed, overall SNR of coronary arteries and veins segments were not different for the two contrast agents (132 ± 79 for gadofosveset vs. 135 ± 78 for gadobenate, p = 0.69). Coronary artery CNR was greater for gadofosveset in comparison to gadobenate (73.5 ± 46.9 vs. 59.3 ± 75.7 respectively, p = 0.03). Gadofosveset-enhanced MRA images displayed better image quality than gadobenate-enhanced MRA images (2.77 ± 0.61 for gadofosveset vs. 2.11 ± 0.51, p < .001). Inter- and intra-reader variability was excellent (ICC > 0.90) for both contrast agents. Gadofosveset trisodium appears to show slightly better performance for coronary MRA at 3 T compared to gadobenate.


Gadofosveset trisodium Gadobenate dimeglumine Coronary MRA 



This research was supported by the NIH intramural research program. Clinical trial registration information—URL: Unique identifier: NCT01130545 (10-CC-0115). Funded by the National Institutes of Health (NIH) Intramural program.

Conflict of interest

The authors declare they have no competing interests.


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Copyright information

© Springer Science+Business Media B.V.(outside the USA) 2013

Authors and Affiliations

  • Fabio S. Raman
    • 1
  • Marcelo S. Nacif
    • 1
    • 2
    • 4
  • George Cater
    • 1
  • Neville Gai
    • 1
  • Jacquin Jones
    • 1
  • Debiao Li
    • 3
  • Christopher T. Sibley
    • 1
    • 4
  • Songtao Liu
    • 1
    • 4
  • David A. Bluemke
    • 1
    • 4
  1. 1.Radiology and Imaging SciencesNational Institutes of Health of Clinical CenterBethesdaUSA
  2. 2.Radiology DepartmentUniversidade Federal FluminenseNiteróiBrazil
  3. 3.Cedars-Sinai Medical CenterUniversity of CaliforniaLos AngelesUSA
  4. 4.Molecular Biomedical Imaging LaboratoryNational Institute of Biomedical Imaging and BioengineeringBethesdaUSA

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