Comparison of a new methodology for the assessment of 3D myocardial strain from volumetric ultrasound with 2D speckle tracking
- 297 Downloads
An alternative approach to extract 3D myocardial strain based on elastic registration of the ultrasound images (3DSE) was developed by our lab. The aim of the present study was to test its clinical performance by comparing strain values obtained by 3DSE with the ones obtained with 2D speckle tracking (2DST). Standard 2D B-mode and volumetric datasets were acquired in 12 patients with coronary heart disease (CHD) and in 12 control subjects. Longitudinal (εLL), circumferential (εCC) and radial (εRR) strain values were obtained from 2D datasets using commercially available 2DST software and from volumetric datasets using the 3DSE approach. 3DSE provided lower strain values than 2DST. With both approaches global εLL and εCC were significantly lower in patients with CHD than in controls. Global εLL and εCC correlated well between both methods (R = 0.83, R = 0.86, respectively), while segmental correlations were moderate [R = 0.63 (εLL), R = 0.41 (εCC)]. The highest differences in εLL values obtained by the two methods and the highest number of erroneous εLL with 3DSE were observed in the basal LV segments. This study shows that in real-life datasets our 3DSE method provides global and regional εLL and εCC values that are comparable with the ones obtained from 2DST, even though they are not interchangeable with each other. As only a single acquisition is required, 3D methods may offer advantages over the current 2D techniques. However, the accuracy of the 3DSE can still be improved by solving the problems that appear with deformation estimation in the basal segments.
Keywords3D strain estimation 2D speckle tracking Elastic registration
This work was funded—in part—by grant G.0693.09 of the Research Foundation—Flanders (Belgium, FWO—Vlaanderen).
Conflict of interest
- 3.Weidemann F, Eyskens B, Mertens L, Di Salvo G, Strotmann J, Buyse G, Claus P, D’hooge J, Bijnens B, Gewillig M, Sutherland GR (2003) Quantification of regional right and left ventricular function by ultrasonic strain and strain rate indexes in Friedreich’s ataxia. Am J Cardiol 91:622–626PubMedCrossRefGoogle Scholar
- 5.Jurcut R, Wildiers H, Ganame J, D’hooge J, De Backer J, Denys H, Paridaens R, Rademakers F, Voigt JU (2008) Strain rate imaging detects early cardiac effects of pegylated liposomal Doxorubicin as adjuvant therapy in elderly patients with breast cancer. J Am Soc Echocardiogr 21(12):1283–1289PubMedCrossRefGoogle Scholar
- 7.Sutherland GR, Hatle L, Claus P, D’hooge J, Bijnens BH (2006) Doppler myocardial imaging—a textbook. BSWK, HasseltGoogle Scholar
- 10.Sengupta PP, Krishnamoorthy V, Korinek J, Narula J, Vannan MA, Lester SJ, Tajik JA, Seward JB, Khandheria BK, Belohlavek M (2007) Left ventricular form and function revisited: applied translational science to cardiovascular ultrasound imaging. J Am Soc Echocardiogr 20:539–551PubMedCrossRefGoogle Scholar
- 14.Perez de Isla L, Balcones DV, Fernández-Golfín C, Marcos-Alberca P, Almería C, Rodrigo JL, Macaya C, Zamorano J (2009) Three-dimensional-wall motion tracking: a new and faster tool for myocardial strain assessment: comparison with two-dimensional-wall motion tracking. J Am Soc Echocardiogr 22(4):325–330PubMedCrossRefGoogle Scholar
- 15.Saito K, Okura H, Watanabe N, Hayashida A, Obase K, Imai K, Maehama T, Kawamoto T, Neishi Y, Yoshida K (2009) Comprehensive evaluation of left ventricular strain using speckle tracking echocardiography in normal adults: comparison of three-dimensional and two-dimensional approaches. J Am Soc Echocardiogr 22(9):1025–1030PubMedCrossRefGoogle Scholar
- 16.Heyde B, Cygan S, Choi HF, Lesniak-Plewinska B, Barbosa D, Elen A, Claus P, Loeckx D, Kaluzynski K, D’hooge J (2010). Three-dimensional cardiac motion and strain estimation: a validation study in thick walled univentricular phantoms. In: Proceedings of the IEEE international ultrasonics symposium, Sam Diego (in press)Google Scholar
- 17.Herbots L (ed) (2006) Description of deformation values in healthy volunteers and the influence of BMI, age and gender. In: Quantification of regional myocardial deformation: normal characteristics and clinical use in ischaemic heart disease. Leuven University Press, Leuven, pp 45–72Google Scholar
- 25.Barbosa D, Kiss G, Claus P, Hristova K, Amundsen B, Loeckx D, Orderud F, Torp H, D’hooge J (2009) A comparison between the methods for automatic quantification of global left ventricular function. In: Proceedings of the IEEE international ultrasonics symposium, Rome, pp 313–316Google Scholar
- 26.Amundsen BH, Crosby J, Steen PA, Torp H, Slordhal SA, Stoylen A (2009) Regional myocardial long-axis strain and strain rate measured by different tissue doppler and speckle tracking echocardiography methods: a comparison with tagged magnetic resonance imaging. Eur J Echocardiogr 10:229–237PubMedCrossRefGoogle Scholar