Increased mortality in patients with conflicting diastolic parameters

Original Paper

DOI: 10.1007/s10554-011-9891-5

Cite this article as:
Bahrainy, S., Vo, M. & Gill, E.A. Int J Cardiovasc Imaging (2012) 28: 735. doi:10.1007/s10554-011-9891-5
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Abstract

The aim of this study was to describe the clinical characteristics and mortality of patients with conflicting diastolic function during follow-up. Up to 30% of patients have conflicting diastolic function by echo Doppler and therefore cannot be classified into a distinct diastolic dysfunction category of stage 1, 2 or 3. Using our established echocardiography data base, we studied a cohort of 250 subjects with conflicting diastolic function. Each individual was compared to two controls with normal diastolic and systolic function. The pre-specified goal of the analysis was a 6-year follow-up. Patients with conflicting diastolic function were more likely to have diabetes, hypertension, and established coronary artery disease. The Cox proportional hazards model determined that the risk of death was significantly higher for conflicting patients compared to patients with normal diastolic parameters (HR: 1.83; 95% CI: 1.32–2.53), P < 0.001. After adjustment for covariates, the risk of death remained elevated for the conflicting group (HR: 1.56; 95% CI: 1.11–2.18), P = 0.009. Conflicting diastolic dysfunction is associated with an increased risk of death compared to individuals with normal function. In conclusion, this emphasizes the need to attain a more precise characterization and categorization for patients with diastolic dysfunction.

Keywords

Echocardiography Doppler echocardiography Diastolic dysfunction Conflicting parameters Mortality 

Abbreviations

CI

Confidence interval

LV

Left ventricle/ventricular

EF

Ejection fraction

HR

Hazards ratio

CVA

Cerebrovascular accident

CHF

Congestive heart failure

HF

Heart failure

SOB

Shortness of breath

Copyright information

© Springer Science+Business Media, B.V. 2011

Authors and Affiliations

  1. 1.Division of CardiologyUniversity of Washington, Harborview Medical CenterSeattleUSA

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