The International Journal of Cardiovascular Imaging

, Volume 28, Issue 2, pp 243–250

Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans

  • Serina A. Neumann
  • Katherine J. Linder
  • Matthew F. Muldoon
  • Kimberly Sutton-Tyrrell
  • Christopher Kline
  • Catherine J. Shrader
  • Elizabeth C. Lawrence
  • Robert E. Ferrell
  • Stephen B. Manuck
Original Paper

Abstract

Atherosclerosis is a heritable trait with little known about specific genetic influences on preclinical measures of plaque formation. Based on relations of parasympathetic-cholinergic function to atherosclerosis and to a choline transporter gene [CHT1 (G/T)] polymorphism, we investigated whether the same allelic variant predicts variation in carotid intima-media thickness (IMT) and plaque formation. Carotid IMT and plaque occurrence as well as genotyping for the CHT1 (G/T) variant were measured in a sample (N = 264) of generally healthy adults (age 30–55) of European ancestry. CHT1 GG homozygotes had greater IMT (P < 0.005) and plaque occurrence (P < 0.020) than T allele carriers. This is the first study showing polymorphic variation in the CHT1 gene to predict early, subclinical measures of carotid atherosclerosis which may aid in understanding cholinergic-vagal processes potentially underlying atherosclerotic risk.

Keywords

Atherosclerosis Intima-media thickness Plaque Cholinergic function Choline transport Acetylcholine 

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Copyright information

© Springer Science+Business Media, B.V. 2011

Authors and Affiliations

  • Serina A. Neumann
    • 1
  • Katherine J. Linder
    • 1
  • Matthew F. Muldoon
    • 2
  • Kimberly Sutton-Tyrrell
    • 3
  • Christopher Kline
    • 4
  • Catherine J. Shrader
    • 1
  • Elizabeth C. Lawrence
    • 4
  • Robert E. Ferrell
    • 4
  • Stephen B. Manuck
    • 5
  1. 1.Department of Psychiatry and Behavioral SciencesEastern Virginia Medical SchoolNorfolkUSA
  2. 2.Center for Clinical Pharmacology, School of MedicineUniversity of PittsburghPittsburghUSA
  3. 3.Graduate School of Public HealthUniversity of PittsburghPittsburghUSA
  4. 4.Department of Human Genetics, Graduate School of Public HealthUniversity of PittsburghPittsburghUSA
  5. 5.Department of PsychologyUniversity of PittsburghPittsburghUSA

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