Combining cardiac magnetic resonance and computed tomography coronary calcium scoring: added value for the assessment of morphological coronary disease?

  • Paul Stolzmann
  • Hatem Alkadhi
  • Hans Scheffel
  • André Plass
  • Sebastian Leschka
  • Volkmar Falk
  • Sebastian Kozerke
  • Christophe Wyss
  • Olivio F. Donati
Original Paper

Abstract

To investigate prospectively, in patients with suspicion of coronary artery disease (CAD), the added value of coronary calcium scoring (CS) as adjunct to cardiac magnetic resonance (CMR) for the diagnosis of morphological coronary stenosis in comparison to catheter angiography (CA). Sixty consecutive patients (8 women; 64 ± 10 years) referred to CA underwent CMR (1.5 T) including perfusion and late gadolinium-enhancement imaging as well as CS with computed tomography. Diagnostic performance was evaluated for CMR and CS separately, and for both methods combined, with CA as reference standard. Best CS threshold combined with a specificity >90% to predict significant stenosis in patients without abnormalities on CMR was determined from receiver operator characteristics (ROC) analysis. Abnormal CMR results were considered to indicate significant stenosis regardless of CS; CS above threshold reclassified patients to have CAD regardless of CMR. CA identified 104/960 (11%) coronary segments with coronary artery stenosis >50% in 36/60 (60%) patients. ROC revealed an area-under-the-curve of 0.83 (95%CI: 0.68-0.99) with the best CS threshold of 495 Agatston score (sensitivity 50%). CMR depicted 128/960 (13%) myocardial segments with abnormalities in 31/60 (52%) patients. Sensitivity, specificity, negative (NPV) and positive predictive value (PPV) of CMR were 78, 88, 72 and 90%. When adding CS to CMR, sensitivity and NPV increased to 89 and 83%, while specificity and PPV slightly decreased to 83 and 89%. Accuracy of the combined approach (87%) was significantly (P < 0.05) higher than that of CMR (82%) alone. Adding CS to CMR improves the accuracy for the detection of morphological CAD.

Keywords

Coronary artery disease Calcium scoring Cardiac magnetic resonance imaging Coronary catheterization 

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Copyright information

© Springer Science+Business Media, B.V. 2010

Authors and Affiliations

  • Paul Stolzmann
    • 2
    • 1
  • Hatem Alkadhi
    • 2
    • 1
  • Hans Scheffel
    • 2
  • André Plass
    • 3
  • Sebastian Leschka
    • 2
  • Volkmar Falk
    • 3
  • Sebastian Kozerke
    • 4
  • Christophe Wyss
    • 5
  • Olivio F. Donati
    • 2
  1. 1.Cardiac MR PET CT ProgramMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Institute of Diagnostic RadiologyUniversity Hospital ZurichZurichSwitzerland
  3. 3.Clinic for Cardiovascular SurgeryUniversity Hospital ZurichZurichSwitzerland
  4. 4.Institute for Biomedical EngineeringETH and University of ZurichZurichSwitzerland
  5. 5.Department of CardiologyUniversity Hospital ZurichZurichSwitzerland

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