ASCI 2010 standardized practice protocol for cardiac magnetic resonance imaging: a report of the Asian society of cardiovascular imaging cardiac computed tomography and cardiac magnetic resonance imaging guideline working group
These practice guidelines are recommended by the Asian Society of Cardiovascular Imaging (ASCI), the sole society in Asia designated for cardiovascular imaging, to provide a framework to healthcare providers for suggested essential elements in cardiac magnetic resonance (CMR) examinations of different disease spectra. The guideline is composed of recommendations on the general technique, acquisition of some basic modules, and protocols on stress tests. The protocols for specific diseases are provided in a table format for quick reference to be easily utilized for everyday clinical CMR.
KeywordsCardiac magnetic resonance imaging Practice guideline Stress protocol ASCI Asia
Advanced cardiac life support
Asian society of cardiovascular imaging
Cardiac magnetic resonance
Echo train length
Fast spin echo
Gradient echo-echo planar imaging
Hypertrophic obstructive cardiomyopathy
Late gadolinium enhancement
Left pulmonary artery
Left ventricular outflow tract
Main pulmonary artery
Right pulmonary artery
Right ventricle outflow tract
Steady state free precession
As the healthcare system, resource allocation, and pattern of diseases [1, 2] in Asia are different from those in Western Society, this practice protocol is recommended by the Asian Society of Cardiovascular Imaging (ASCI), the sole society dedicated to cardiovascular imaging in Asia, to provide a frame work for the suggested essential elements in cardiac magnetic resonance (CMR) examinations.
It must be emphasized that this guideline has been built on previously published guidelines from various professional societies [3, 4, 5, 6], but is customized for CMR practice in Asia with its unique characteristics and where thalassemia [7, 8, 9] and valvular heart disease are common. The ultimate decision regarding the propriety of any specific procedure must be made after mutual communication with the referring physicians; the understanding of individual patient’s condition; and the availability of resources, knowledge and technology provided by their respective centers by the responsible individuals participating and performing the CMR procedures.
The practice protocol starts with recommendations on the general technique and is followed by techniques on the acquisition of some basic modules. Recommended practice protocols on stress tests with separate checklists and monitoring sheets are provided. Protocols for specific diseases are summarized in a table format for quick reference.
Recommended practice protocol for CMR examination
Check for any contraindication for MR examination, stress study, and contrast administration, if needed.
Obtain informed consent for the MR examination.
Advise patient on fasting before examination. This is not mandatory, but is advised.
Have patient stop intake of caffeine-containing food and beverages, theophylline or dipyridamole at least 24 h before adenosine study; avoid beta-blocker and nitrates for dobutamine study.
Educate and provide practice to patients on the breathing instruction.
Provide the patient with ear plugs.
Prepare the skin of the chest and/or abdomen for optimal attachment of electrodes for cardiac and respiratory gating.
Position the patient in the best comfortable supine position. Have the patient place the arms above the head to decrease wrap artifact. It is acceptable to put the arms along the side or crossed over the chest if the patient cannot tolerate arms overhead for extended periods of time.
Equipment and safety
Monitoring equipment (blood pressure, electrocardiogram, intercom communication with patients)
- 2.Resuscitation facilities :
emergency resuscitation policy in place
availability of resuscitation team with medical/nursing staff having ACLS accreditation
logistics for transferring patient to designated resuscitation area outside scanner
resuscitation trolley with full set of emergency medications and equipment
external pacer and defibrillator
beta-blockers, nitrates, and aminophylline at hand
Stress MRI testing.
Detail on safety and equipment needed is listed in the performance protocol for the adenosine and dobutamine studies
Recommended practice protocol on basic modules
Left ventricular (LV) structure and function module
Calibrate for parallel imaging technique, if it is to be used.
Transaxial (8–10 mm) set of SSFP or fast spin echo (FSE) images through the chest.
- 4.Vertical long axis scout cine images
The vertical long axis scout cine plane is prescribed from the axial localizer at the level of mitral and tricuspid valves.
The slice through the LV apex and centre of the mitral valve is prescribed.
Horizontal long axis scout cine images.The horizontal long axis scout cine plane is prescribed from the end systolic phase of the vertical long axis scout cine image.
Position the slice at the center of the mitral valve and angulate through the LV apex.
Scroll through the diastolic images to ensure the left atrium is included and properly imaged.
Short axis cine images.The short axis cine planes are prescribed from previously acquired long axis scout cines at diastole, starting from the mitral valve plane through the LV apex, covering the whole ventricle perpendicular to the interventricular septum on horizontal long axis scout cine images.
Slice thickness 6–8 mm; no gap
Temporal resolution ≤45 ms between phases
Parallel imaging to shorten scanning time
- 7.Other long axis cine images
The four chamber cine plane is prescribed from the vertical long axis scout cine and short axis cine images. The cut plane should pass through the LV apex and centre of mitral valve on the vertical long axis scout cine image. On the short axis cine image, angulate the cut plane so that it passes through the center of the LV chamber and lower corner of the RV border sure to avoid bisecting the LV outflow tract in the basal short axis view.
The two chamber cine image is prescribed by a cut plane that bisects the LV apex and centre of the mitral valve in the four chamber view, as well as passing through the mid LV chamber in the short axis view. The cut plane needs to be in parallel to the ventricular septum in both views.
The three chamber cine image is prescribed by a cut plane parallel to the long axis with the bisecting mitral valve and apex as well as the bisecting LV outflow tract in basal short axis view.
The LV outflow tract (LVOT) long axis is obtained in the oblique coronal plane from the true axial scout images by positioning the slice through the aortic root and directing it toward the LV apex.
Additional views of cine images.
A contiguous stack of transaxial steady state free precession cine images from the top of the aortic arch to the inferior wall of the LV is recommended for congenital heart disease.
Right ventricular (RV) structure and function module
- 1.Right ventricular two chamber long axis view
Obtain the right ventricular two chamber long axis images from four chamber images
Position the centre of the slice in the middle of the tricuspid valve and angulate through the RV apex. Scroll through phases to ensure the slice passes through the end-systolic and end-diastolic RV apex of the four chamber images.
Right ventricular outflow view (RVOT).
Prescribe by placing the slice through the centre of main pulmonary artery and the RV apex through a set of axial images.
Right ventricular inflow and outflow view.An inflow/outflow plane of the RV can be acquired using a three-point plane.
Place the first point on the tricuspid valve of the four chamber view.
Place the second point on the RV apex of the two chamber RV view.
Place the third point on the pulmonary valve of the RVOT view.
Gadolinium first pass perfusion module
Use scout imaging as per the LV structure and function module.
Use saturation-recovery imaging with gradient echo-echo planar imaging (GRE-EPI) hybrid, GRE, or SSFP readout.
Use at least three short axis slices per each heart beat (basal, mid, and apical level of LV). Add one slice in four chamber (for sepal/lateral segment ischemia) or two chamber view (for anterior/inferior segment) if the length of the RR interval permits.
Acquire the apical short axis slice first and the most basal short axis last during the cardiac cycle to minimize cardiac motion artifacts.
Use a slice thickness of 8–10 mm, in-plane resolution, ~<3 mm; twofold acceleration and temporal resolution <100 ms or shorter.
Do a dry run at the end expiration for 5–10 phases to check and correct any position and phase wrap artifacts.
- 7.Use the following parameters:
Give contrast (0.05–0.1 mmol/kg, 3–7 ml/s) followed by at least 30 ml saline flush (5–7 ml/s)
Start breathhold during early phases of contrast infusion before contrast reaches the LV cavity.
Readout for 50–60 heart beats to capture the contrast wash-in and wash-out through LV myocardium.
Late gadolinium enhancement (LGE) module
Wait for 10 min after administration of cumulative dose of 0.1–0.2 mmol/kg gadolinium. A shorter delay time may be considered if lower doses of contrast are used.
Use 2D segmented inversion recovery GRE imaging during the end of the diastolic phase.
Prescribe the slices at the identical location, views, and thicknesses as for cine imaging (short- and long-axis views).
In-plane resolution, ~1.4–1.8 mm; adjust acquisition duration to a shorter RR interval in tachycardia.
Set inversion time to null normal myocardium.
Adjust the read-out according to heart rate. Every other heart beat in normal setting of heart rate; every heart beat in the setting of bradycardia, and every third heart beat in the setting of tachycardia or arrhythmia.
Consider using either body coil or functional surface coil intensity correction algorithms.
Use breathhold, pre-contrast segmented FSE imaging (double inversion recovery).
Select slice locations based on the suspected area of acute edema or inflammation on cine images.
Use a thick (10–12 mm) slice.
Obtain short axis, mid ventricular slices by multiple breathholds, spoiled gradient echo sequences with nine echo time (5.6–18 ms) for T2* measurement for iron detection. Adjust the TR between the 9 RF (segment) pulses according to the different TE times.
Valvular flow and shunt assessment module
- 1.Quantitative flow measurement
For the flow velocity and volume, the plane of measurement should be perpendicular to the vessel and distal to valve leaflet tips of interest. Adapt velocity encoding to actual velocity by the lowest velocity without aliasing, and use the lowest TE possible for high velocity jet flows.
Specific plane for phase contrast (PC) flow acquisition.For the acquisition of different chamber views stated below, please refer to the basic modules on structure and function of LV and RV in Sections A & B.
Mitral Valve: Plan on the end-systolic two chamber and four chamber cine images. The center of the slice is placed in the middle of the mitral valve and angulated parallel to the mitral valve.
Tricuspid Valve: Plan on true four-chamber and RV two-chamber images at the end systolic phase. The center of the slice is placed in the middle of the tricuspid valve and angulated parallel to the tricuspid valve.
Aortic Valve: Alignment of the imaging plan for the aortic valve is from the three chamber and LVOT views. The imaging plane should be positioned just above the aortic valve, yet just below the origin of the coronary arteries. The LVOT view is prescribed perpendicular to the three chamber view.
Pulmonary Valve: Align the imaging plane from two orthogonal RVOT views and place the plane just above the pulmonary valve. The first RVOT view is prescribed from an oblique plane through the main PA and RV on a set of axial images. The second RVOT plane is prescribed perpendicular to the first RVOT.
Pulmonary Arteries: Main pulmonary artery (MPA)
Prescribe from sagittal localizer and obtain a few cine slices parallel to the MPA. The imaging plane for flow acquisition should be perpendicular to the direction of flow to the MPA on these images. The usual peak velocity is 180 cm/s. The encoding velocity recommended for the first measurement or for flow measurement is 180 cm/s.
Left pulmonary artery (LPA) and right pulmonary artery (RPA) Imaging planes through the LPA and RPA should be perpendicular to the direction of flow and proximal to the first branching vessel. In general, these planes are usually 1–1.5 cm distal to the MPA bifurcation. The usual velocity for peak measurement is 60–120 cm/s. The recommended encoding velocity for the first measurement or for flow measurement is 200 cm/s.
Ascending Aorta: Prescribe the imaging plane from the coronal localizer. The flow acquisition is performed perpendicular to the flow direction of the ascending aorta, about 1.5–2 cm above the aortic valve at the pulmonary bifurcation level. The usual peak velocity measurement is 100–160 cm/s. The recommended encoding velocity for the first measurement or for flow measurement is 200 cm/s.
- 2.Qualitative assessment
Use gradient echo or hybrid gradient echo/echo planar imaging as either is better in visualizing the severity of regurgitant jets or turbulence across shunts.
For the morphology and planimetry of valve orifice, optimize the angle and level with SSFP in the plane of the valve of interest and use three contiguous 5 mm-thick high resolution cines transecting the line of the jet and moving from orifice level to immediately downstream.
- iii.Specific plane for assessment:
Mitral valve: horizontal and vertical long axis, LVOT view
Aortic valve: LVOT and coronal view
Tricuspid valve: horizontal long axis and transaxial view
Pulmonary valve: RV long axis or RVOT view
Recommended protocol for adenosine stress test
Follow the checklist attached and set up according to the monitoring sheet for adenosine stress myocardial perfusion test.
Perform LV structure and function module as listed or alternatively acquire these images at between stress and rest perfusion to shorten scanning time.
- 3.Start continuous adenosine infusion (at least 3 min, preferably 4–6 min continuous infusion of 140 μg/kg body weight/min) and then
Perform the gadolinium first pass perfusion module; update the heart rate in response to the heart rate increase caused by adenosine.
Gadolinium is injected (0.05–0.1 mmol/kg) during the last minute of adenosine infusion.
Stop adenosine infusion after imaging for 50–60 heart beats when the gadolinium has passed through LV myocardium.
Continuous ECG monitoring, oxygen saturation monitoring and repeated BP measured at baseline, during infusion, and for at least 2 min post-infusion of adenosine (see the monitoring sheet).
- 4.Rest Perfusion
Perform only after at least 10 min washout period for the gadolinium from stress perfusion imaging.
Repeat perfusion imaging without adenosine using same dose of gadolinium and at the same slice location, again update the heart rate.
Consider skipping if the stress perfusion is free from artifact. However, additional gadolinium may be considered for late gadolinium enhancement imaging (for a cumulative total dose of 0.1–0.2 mmol/kg).
Perform the LGE module after waiting for about 10 min after the last dose of contrast.
Recommended protocol for dobutamine stress test
Follow the attached checklist and set up according to the monitoring sheet for dobutamine stress myocardial perfusion test.
Follow baseline LV structure and function module.
- 3.Dobutamine continuous infusion:
Increase the dobutamine infusion in increments of 10 μg/kg body weight/minute every 3 min starting at 10 μg/kg body weight/min until target heart rate [85% × (220-age)] is reached.
Add atropine 0.3 mg in fractional doses up to 2 mg, if heart rate response is poor.
Repeat 3 short axis (basal, mid ventricular, and distal views) and 3 long axis cine views during each increment of dobutamine dosing.
Continuously monitor ECG and oxygen, and measure BP at baseline, during each stage and at least 10 min after stress test (see the monitoring sheet).
View cine loops online as they are being acquired at each stage during real-time or almost at real-time.
Optimize the temporal resolution at every dosage as the heart rate increases.
Stop test at detection of any new wall motion or thickening abnormality; systolic blood pressure increase >240 mmHg and/or diastolic blood pressure >120 mmHg; Blood pressure decrease >20 mmHg below baseline systolic blood pressure and/or decrease >40 mmHg from a previous level; severe chest pain or other intractable symptoms; complex cardiac arrhythmias or achievement of peak heart rate.
Perform first pass perfusion at peak stress with gadolinium at 0.05–0.075 mmol/kg as described in the perfusion module, wait for 20 min before acquisition of rest perfusion.
Perform the LGE module after waiting for at least 10 min after the last dose of gadolinium injection (at a cumulative dose of 0.1–0.2 mmol/kg).
The working group would like to acknowledge Mr Lawrance Yip, the senior radiographer, Queen Mary Hospital, Hong Kong for the acquisition of images and Dr Stephen CW Cheung, the consultant radiologist, Queen Mary Hospital, Hong Kong for the contribution on the worksheets for stress studies.
The members of the working group have nothing to declare on the potential conflict of interest.
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
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