Multi-contrast high spatial resolution black blood inner volume three-dimensional fast spin echo MR imaging in peripheral vein bypass grafts
The purpose of this study is to primarily evaluate the lumen area and secondarily evaluate wall area measurements of in vivo lower extremity peripheral vein bypass grafts patients using high spatial resolution, limited field of view, cardiac gated, black blood inner volume three-dimensional fast spin echo MRI. Fifteen LE-PVBG patients prospectively underwent ultrasound followed by T1-weighted and T2-weighted magnetic resonance (MR) imaging. Lumen and vessel wall areas were measured by direct planimetry. For graft lumen areas, T1- and T2-weighted measurements were compared with ultrasound. For vessel wall areas, differences between T1- and T2-weighted measurements were evaluated. There was no significant difference between ultrasound and MR lumen measurements, reflecting minimal MR blood suppression artifact. Graft wall area measured from T1-weighted images was significantly larger than that measured from T2-weighted images (P < 0.001). The mean of the ratio of T1- versus T2-weighted vessel wall areas was 1.59 (95% CI: 1.48–1.69). The larger wall area measured on T1-weighted images was due to a significantly larger outer vessel wall boundary. Very high spatial resolution LE-PVBG vessel wall MR imaging can be performed in vivo, enabling accurate measurements of lumen and vessel wall areas and discerning differences in those measures between different tissue contrast weightings. Vessel wall area differences suggest that LE-PVBG vessel wall tissues produce distinct signal characteristics under T1 and T2 MR contrast weightings.
KeywordsMagnetic resonance imaging Vein bypass grafts Remodeling Peripheral vascular disease
Funding sources: This research was supported in part by NIH K23-EB00882 and NIH R01-HL075771.
The authors report no conflicts.
- 7.Kuribayashi H, Tessier JJ, Checkley DR, Wang YX, Hultin L, Waterton JC (2004) Effective blood signal suppression using double inversion-recovery and slice reordering for multislice fast spin-echo MRI and its application in simultaneous proton density and T2 weighted imaging. J Magn Reson Imaging 20:881–888CrossRefPubMedGoogle Scholar
- 31.Wang J, Yarnykh VL, Hatsukami T, Chu B, Balu N, Yuan C (2007) Improved suppression of plaque-mimicking artifacts in black-blood carotid atherosclerosis imaging using a multislice motion-sensitized driven-equilibrium (MSDE) turbo spin-echo (TSE) sequence. Magn Reson Med 58:973–981CrossRefPubMedGoogle Scholar
- 32.Crowe LA, Ariff B, Keegan J, Mohiaddin RH, Yang GZ, Hughes AD, Mc GTSA, Firmin DN (2005) Comparison between three-dimensional volume-selective turbo spin-echo imaging and two-dimensional ultrasound for assessing carotid artery structure and function. J Magn Reson Imaging 21:282–289CrossRefPubMedGoogle Scholar
- 35.Rybicki FJ, Mitsouras D, Owens CD, Whitmore AG, Ersoy H, Mulkern RV, Creager MA, Conte MS (2008) Lower extremity peripheral vein bypass graft wall thickness changes demonstrated at 1 and 6 months after surgery with ultra-high spatial resolution black blood inner volume three-dimensional fast spin echo magnetic resonance imaging. Int J Cardiovasc Imaging 24:529–533CrossRefPubMedGoogle Scholar
- 37.Mitsouras D, Owens CD, Conte MS, Ersoy H, Creager MA, Rybicki FJ, Mulkern RV (2009) In vivo differentiation of two vessel wall layers in lower extremity peripheral vein bypass grafts: application of high-resolution inner-volume black blood 3D FSE. Magn Reson Med 62:607–615CrossRefPubMedGoogle Scholar
- 49.Lau GT, Ridley LJ, Bannon PG, Wong LA, Trieu J, Brieger DB, Lowe HC, Freedman BS, Kritharides L (2006) Lumen loss in the first year in saphenous vein grafts is predominantly a result of negative remodeling of the whole vessel rather than a result of changes in wall thickness. Circulation 114:I435–I440CrossRefPubMedGoogle Scholar