Carotid artery intima media thickness, plaque and framingham cardiovascular score in Asia, Africa/Middle East and Latin America: the PARC-AALA Study
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The PARC-AALA (Paroi artérielle et Risque Cardiovasculaire in Asia Africa/ Middle East and Latin America) study was designed to evaluate the correlation between intima-media thickness of the common carotid artery (CCAIMT), carotid plaque and absolute cardiovascular risk in a multi-ethnic population.
An international, cross-sectional, study including 79 centres from 21 countries in Asia, Africa, the Middle East and Latin America. Two thousand three hundred and twenty-eight subjects, meeting all inclusion criteria, were stratified by risk factors groups (no modifiable factor or at least both uncontrolled hypertension and hypercholesterolemia). CCAIMT, presence of plaque and cardiovascular risk factors were assessed for each individual.
Some intergeographical characteristics in demographics, and risk factors were found accompanying early atherosclerosis marker differences. In Asia where the subjects were at lower risk, the mean CCAIMT was 4% lower than in Africa/Middle East and Latin America. On multiple linear regression analysis CCAIMT and carotid plaque were independently associated with increased Framingham cardiovascular score (FCS) without heterogeneity across geographic regions. CCAIMT and carotid plaque explained roughly 20% of the FCS in both genders.
The PARC-AALA study confirms the correlation between CCAIMT and FCS in three different populations. Intima-media thickness (IMT) and plaque evaluation may represent a complementary predictive tool for detection of cardiovascular disease in individuals.
KeywordsCarotid plaque Framingham score Hypercholesterolemia Hypertension Intima media thickness Ultrasound
Body mass index
British Regional Heart Study
Common carotid artery
Common carotid artery intima-media thickness
Coronary heart disease
Framingham cardiovascular score
High density lipoprotein
Low density lipoprotein
Left ventricular hypertrophy
- 2.Touboul PJ, Crouse JR (eds) (1997) Intima media thickness and atherosclerosis: predicting the risk? Parthenon Publishing Group, LondonGoogle Scholar
- 10.NCEP Expert Panel. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002 Dec; 106(25):3143–3421Google Scholar
- 11.Touboul PJ, Vicaut E, Labreuche J et al Correlation between the Framingham risk score and intima media thickness: The Paroi Arterielle et Risque Cardio-vasculaire (PARC) study. Atherosclerosis Epub 2006 Jun 10Google Scholar
- 14.Touboul PJ, Elbaz A, Koller C et al (2000) Common carotid artery intima-media thickness and brain infarction: the Etude du Profil Genetique de l’Infarctus Cerebral (GENIC) case-control study. The GENIC Investigators. Circulation 102(3):313–318Google Scholar