Epidemiological trends of oropharyngeal and oral cavity squamous cell carcinomas in Northern New England, 2000–2013

  • Adepitan A. OwoshoEmail author
  • Miguel VelezIII
  • Alexander Tyburski
  • John Hofheins
  • Rashidah Wiley
  • Tessie Stansbury
  • Semiu O. Gbadamosi
  • Jon S. Ryder
Original Paper



This study examines the epidemiological trends of oropharyngeal squamous cell carcinoma (OPSCC) and oral cavity squamous cell carcinoma (OCSCC) in Northern New England.


Data were obtained from the Maine, New Hampshire and Vermont cancer registries. The age-standardized incidence rates (ASIR), age-specific incidence rates, and annual percentage changes (APC) for OPSCC and OCSCC were calculated using Joinpoint regression.


The overall ASIR for OPSCC in Northern New England increased by 54.2% from 2000 to 2013 with an increase of 61.5% and 27.3% in men and women, respectively. Overall ASIR for OCSCC, on the other hand, declined throughout 2000 to 2013 by 6% and among men by 11%. In joinpoint analyses, the overall ASIRs for OPSCC significantly increased at an APC of 3.15 from 2000 to 2013, whereas the ASIRs for OCSCC remained stable at an APC of − 0.26. In men, ASIRs for OPSCC significantly increased (APC: 3.46), while that of OCSCC remained stable at an APC of − 0.87. In women, the ASIRs remained stable for both OPSCC and OCSCC at an APC of 1.97 and 0.49, respectively. For patients in the 6th decade of life, the age-specific incidence rates for OPSCC increased significantly at an APC of 3.06, also among those in the 7th and 8th decade with a significant increase at an APC of 4.98 and 3.51 per year, respectively. There were no significant changes in the APC of patients with OCSCC with respect to age group.


The overall incidence of OPSCC is increasing in Northern New England, specifically among men. Given the etiological association between OPSCC and HPV, vaccination against HPV should be effectively encouraged among the populace. The efforts on tobacco cessation, abstinence, and alcohol abuse control should be continually expanded in order to bring about a decreasing trend in OCSCC.


HPV Oropharynx Head and neck cancer Maine New Hampshire Vermont 



This project was supported in part by the Centers for Disease Control and Prevention’s National Program of Cancer Registries, cooperative agreement 5U58DP003930 awarded to the New Hampshire Department of Health and Human Services, Division of Public Health Services, Bureau of Public Health Statistics and Informatics, Office of Health Statistics and Data Management. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention or the New Hampshire Department of Health and Human Services. This project was also supported in part by the cooperative agreement 1NU58DP006297 funded by the Centers for Disease Control and Prevention awarded to the Maine Department of Health and Human Services. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Maine Centers for Disease Control and Prevention or the Department of Health and Human Services. We would like to thank Maine, New Hampshire and Vermont Cancer Registries for sharing the states data.

Compliance with ethical standards

Conflict of interest

All authors declare that there are no financial conflicts associated with this study.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Adepitan A. Owosho
    • 1
    Email author
  • Miguel VelezIII
    • 1
  • Alexander Tyburski
    • 1
  • John Hofheins
    • 1
  • Rashidah Wiley
    • 1
  • Tessie Stansbury
    • 1
  • Semiu O. Gbadamosi
    • 2
  • Jon S. Ryder
    • 1
  1. 1.College of Dental MedicineUniversity of New EnglandPortlandUSA
  2. 2.Department of Epidemiology, Robert Stempel College of Public Health and Social WorkFlorida International UniversityMiamiUSA

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