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Body size and dietary risk factors for aggressive prostate cancer: a case–control study

  • Mikaela PalEmail author
  • Allison M. Hodge
  • Nathan Papa
  • Robert J. MacInnis
  • Julie K. Bassett
  • Damien Bolton
  • Ian D. Davis
  • Jeremy Millar
  • Dallas R. English
  • John L. Hopper
  • Gianluca Severi
  • Melissa C. Southey
  • Roger L. Milne
  • Graham G. Giles
Original Paper

Abstract

Purpose

Diet and body size may affect the risk of aggressive prostate cancer (APC), but current evidence is inconclusive.

Methods

A case–control study was conducted in men under 75 years of age recruited from urology practices in Victoria, Australia; 1,254 with APC and 818 controls for whom the presence of prostate cancer had been excluded by biopsy. Dietary intakes were assessed using a validated food frequency questionnaire. Multivariable unconditional logistic regression estimated odds ratios and confidence intervals for hypothesized risk factors, adjusting for age, family history of prostate cancer, country of birth, socioeconomic status, smoking, and other dietary factors.

Results

Positive associations with APC (odds ratio, 95% confidence intervals, highest vs. lowest category or quintile) were observed for body mass index (1.34, 1.02–1.78, Ptrend = 0.04), and trouser size (1.54, 1.17–2.04, Ptrend = 0.001). Intakes of milk and all dairy products were inversely associated with APC risk (0.71, 9.53–0.96, Ptrend = 0.05, and 0.64, 0.48–0.87, Ptrend = 0.012, respectively), but there was little evidence of an association with other dietary variables (Ptrend > 0.05).

Conclusions

We confirmed previous evidence for a positive association between body size and risk of APC, and suggest that consumption of dairy products, and milk more specifically, is inversely associated with risk.

Keywords

Aggressive prostate cancer Body mass index Diet Nutrition Case–control study 

Notes

Acknowledgments

This study was funded by National Health and Medicine Research Council (NHMRC) project grant #623204 and ethical approval was granted by the Cancer Council Victoria Human Research Ethics Committee (#910). IDD is supported by an NHMRC Practitioner Fellowship (Grant No. APP1102604). MCS is supported by an NHMRC Senior Research Fellowship (Grant No. APP1155163).

Compliance with ethical standards

Conflict of interest

NP is currently employed by Janssen-Cilag Pty Ltd. The company had no role in producing this manuscript.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (Cancer Council Victoria Human Research Ethics Committee, #910) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

References

  1. 1.
    Australian Institute of Health and Welfare (2019) Cancer in Australia 2019. Cancer series no. 199. Cat. No. CAN 123. Canberra: AIHWGoogle Scholar
  2. 2.
    Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries: Global Cancer Statistics 2018. CA Cancer J Clin 68(6):394–424.  https://doi.org/10.3322/caac.21492 CrossRefPubMedGoogle Scholar
  3. 3.
    Giovannucci E, Liu Y, Platz EA, Stampfer MJ, Willett WC (2007) Risk factors for prostate cancer incidence and progression in the health professionals follow-up study. Int J Cancer 121(7):1571–1578CrossRefGoogle Scholar
  4. 4.
    World Cancer Research Fund/American Institute for Cancer Research. Continuous Update Project Expert Report 2018. Diet, nutrition, physical activity and prostate cancer. https://dietandcancerreport.org
  5. 5.
    Leitzmann M, Rohrmann S (2012) Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates. Clin Epidemiol. 4:1–11.  https://doi.org/10.2147/CLEP.S16747 CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Möller E, Wilson KM, Batista JL, Mucci LA, Bälter K, Giovannucci E (2016) Body size across the life course and prostate cancer in the Health Professionals Follow-up Study: Body size and prostate cancer. Int J Cancer. 138(4):853–865.  https://doi.org/10.1002/ijc.29842 CrossRefPubMedGoogle Scholar
  7. 7.
    Giovannucci E, Rimm EB, Liu Y, Leitzmann M, Wu K, Stampfer MJ, et al (2003) Body mass index and risk of prostate cancer in U.S. health professionals. JNCI J Natl Cancer Inst. 95(16):1240–1244CrossRefPubMedGoogle Scholar
  8. 8.
    Gong Z, Neuhouser ML, Goodman PJ, Albanes D, Chi C, Hsing AW et al (2006) Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial. Cancer Epidemiol Biomark Prev 15(10):1977–1983CrossRefGoogle Scholar
  9. 9.
    Kelly SP, Lennon H, Sperrin M, Matthews C, Freedman ND, Albanes D et al (2018) Body mass index trajectories across adulthood and smoking in relation to prostate cancer risks: the NIH-AARP Diet and Health Study. Int J Epidemiol.  https://doi.org/10.1093/ije/dyy/219 CrossRefPubMedCentralGoogle Scholar
  10. 10.
    Antwi SO, Steck SE, Su LJ, Hebert JR, Zhang H, Craft NE et al (2016) Carotenoid intake and adipose tissue carotenoid levels in relation to prostate cancer aggressiveness among African-American and European-American men in the North Carolina-Louisiana prostate cancer project (PCaP): carotenoids and prostate cancer aggressiveness. Prostate 76(12):1053–1066.  https://doi.org/10.1002/pros.23189 CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Giovannucci E, Rimm EB, Liu Y, Stampfer MJ, Willett WC (2002) A prospective study of tomato products, lycopene, and prostate cancer risk. J Natl Cancer Inst 94(5):391–398CrossRefGoogle Scholar
  12. 12.
    Perez-Cornago A, Travis RC, Appleby PN, Tsilidis KK, Tjønneland A, Olsen A et al (2017) Fruit and vegetable intake and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC): fruit, vegetable intake and prostate cancer risk. Int J Cancer 141(2):287–297.  https://doi.org/10.1002/ijc.30741 CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Hardin J, Cheng I, Witte JS (2011) Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk. Nutr Cancer 63(6):860–872.  https://doi.org/10.1080/01635581.2011.582224 CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Kirsh VA, Peters U, Mayne ST, Subar AF, Chatterjee N, Johnson CC et al (2007) Prospective study of fruit and vegetable intake and risk of prostate cancer. JNCI J Natl Cancer Inst 99(15):1200–1209CrossRefGoogle Scholar
  15. 15.
    Liu B, Mao Q, Cao M, Xie L (2012) Cruciferous vegetables intake and risk of prostate cancer: a meta-analysis: cruciferous vegetables and prostate cancer. Int J Urol 19(2):134–141.  https://doi.org/10.1111/j.1442-2042.2011.02906.x CrossRefPubMedGoogle Scholar
  16. 16.
    Zhou X-F, Ding Z-S, Liu N-B (2013) Allium vegetables and risk of prostate cancer: evidence from 132,192 subjects. Asian Pac J Cancer Prev 14(7):4131–4134CrossRefGoogle Scholar
  17. 17.
    Hsing AW, Chokkalingam AP, Gao YT, Madigan MP, Deng J, Gridley G et al (2002) Allium vegetables and risk of prostate cancer: a population-based study. J Natl Cancer Inst 94(21):1648–1651CrossRefGoogle Scholar
  18. 18.
    Lovegrove C, Ahmed K, Challacombe B, Khan MS, Popert R, Dasgupta P (2015) Systematic review of prostate cancer risk and association with consumption of fish and fish-oils: analysis of 495,321 participants. Int J Clin Pract 69(1):87–105.  https://doi.org/10.1111/ijcp.12514 CrossRefPubMedGoogle Scholar
  19. 19.
    Augustsson K, Michaud DS, Rimm EB, Leitzmann MF, Stampfer MJ, Willett WC et al (2003) A prospective study of intake of fish and marine fatty acids and prostate cancer. Cancer Epidemiol Biomark Prev 12(1):64–67Google Scholar
  20. 20.
    Wu K, Spiegelman D, Hou T, Albanes D, Allen NE, Berndt SI et al (2016) Associations between unprocessed red and processed meat, poultry, seafood and egg intake and the risk of prostate cancer: a pooled analysis of 15 prospective cohort studies: meat, seafood, eggs and prostate cancer. Int J Cancer 138(10):2368–2382.  https://doi.org/10.1002/ijc.29973 CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Wilson KM, Mucci LA, Drake BF, Preston MA, Stampfer MJ, Giovannucci E et al (2016) Meat, fish, poultry, and egg intake at diagnosis and risk of prostate cancer progression. Cancer Prev Res (Phila) 9(12):933–941CrossRefGoogle Scholar
  22. 22.
    Aune D, Navarro Rosenblatt DA, Chan DS, Vieira AR, Vieira R, Greenwood DC et al (2015) Dairy products, calcium, and prostate cancer risk: a systematic review and meta-analysis of cohort studies. Am J Clin Nutr 101(1):87–117.  https://doi.org/10.3945/ajcn.113.067157 CrossRefPubMedGoogle Scholar
  23. 23.
    Steck SE, Omofuma OO, Su LJ, Maise AA, Woloszynska-Read A, Johnson CS et al (2018) Calcium, magnesium, and whole-milk intakes and high-aggressive prostate cancer in the North Carolina-Louisiana Prostate Cancer Project (PCaP). Am J Clin Nutr 107(5):799–807.  https://doi.org/10.1093/ajcn/nqy037 CrossRefPubMedGoogle Scholar
  24. 24.
    Giovannucci E, Liu Y, Stampfer MJ, Willett WC (2006) A prospective study of calcium intake and incident and fatal prostate cancer. Cancer Epidemiol Biomark Prev 15(2):203–210CrossRefGoogle Scholar
  25. 25.
    Batai K, Murphy AB, Ruden M, Newsome J, Shah E, Dixon MA et al (2017) Race and BMI modify associations of calcium and vitamin D intake with prostate cancer. BMC Cancer 17(1):64.  https://doi.org/10.1186/s12885-017-3060-8 CrossRefPubMedPubMedCentralGoogle Scholar
  26. 26.
    Petimar J, Wilson KM, Wu K, Wang M, Albanes D, van den Brandt PA et al (2017) A pooled analysis of 15 prospective cohort studies on the association between fruit, vegetable, and mature bean consumption and risk of prostate cancer. Cancer Epidemiol Biomark Prev 26(8):1276–1287.  https://doi.org/10.1158/1055-9965.EPI-16-1006 CrossRefGoogle Scholar
  27. 27.
    Lane JA, Oliver SE, Appleby PN, Lentjes MAH, Emmett P, Kuh D et al (2017) Prostate cancer risk related to foods, food groups, macronutrients and micronutrients derived from the UK Dietary Cohort Consortium food diaries. Eur J Clin Nutr 71(2):274–283.  https://doi.org/10.1038/ejcn.2016.162 CrossRefPubMedGoogle Scholar
  28. 28.
    Key TJ, Allen N, Appleby P, Overvad K, Tjønneland A, Miller A et al (2004) Fruits and vegetables and prostate cancer: no association among 1,104 cases in a prospective study of 130,544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC): fruits and vegetables and prostate cancer. Int J Cancer 109(1):119–124CrossRefGoogle Scholar
  29. 29.
    Stram DO, Hankin JH, Wilkens LR, Park S, Henderson BE, Nomura AM et al (2006) Prostate cancer incidence and intake of fruits, vegetables and related micronutrients: the multiethnic cohort study (United States). Cancer Causes Control 17:1193–1207CrossRefGoogle Scholar
  30. 30.
    Takachi R, Inoue M, Sawanda N, Iwasaki M, Sasazuki S, Ishihara J et al (2010) Fruits and vegetables in relation to prostate cancer in Japanese men: the Japan Public Health Center-Based Prospective Study. Nutr Cancer 62(1):30–39.  https://doi.org/10.1080/01635580903191502 CrossRefPubMedGoogle Scholar
  31. 31.
    Bylsma LC, Alexander DD (2015) A review and meta-analysis of prospective studies of red and processed meat, meat cooking methods, heme iron, heterocyclic amines and prostate cancer. Nutr J 14:125.  https://doi.org/10.1186/s12937-015-0111-3 CrossRefPubMedPubMedCentralGoogle Scholar
  32. 32.
    Rohrmann S, Platz EA, Kavanaugh CJ, Thuita L, Hoffman SC, Helzlsouer KJ (2007) Meat and dairy consumption and subsequent risk of prostate cancer in a US cohort study. Cancer Causes Control 18(1):41–50CrossRefGoogle Scholar
  33. 33.
    Allen NE, Key TJ, Appleby PN, Travis RC, Roddam AW, Tjønneland A et al (2008) Animal foods, protein, calcium and prostate cancer risk: the European Prospective Investigation into Cancer and Nutrition. Br J Cancer 98(9):1574–1581.  https://doi.org/10.1038/sj.bjc.6604331 CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    Bassett JK, English DR, Fahey MT, Forbes AB, Gurrin LC, Simpson JA et al (2016) Validity and calibration of the FFQ used in the Melbourne Collaborative Cohort Study. Public Health Nutr 19(13):2357–2368.  https://doi.org/10.1017/S1368980016000690 CrossRefPubMedGoogle Scholar
  35. 35.
  36. 36.
    Food Standards Australia New Zealand AUSNUT (2007) https://www.foodstandards.gov.au/science/monitoringnutrients/ausnut/Pages/ausnut2007.aspx. Accessed Aug 2013
  37. 37.
    US Department of Agriculture, Agricultural Research Service (2013) USDA National Nutrient Database for Standard Reference, Release 26. Nutrient Data Laboratory Home Page. https://www.ars.usda.gov/ba/bhnrc/ndl. Accessed Aug 2013
  38. 38.
    Australian Bureau of Statistics (2011) Census of population and housing: Socio-Economic Indexes for Areas (SEIFA), Australia, 2011. https://www.abs.gov.au/ausstats/abs@.nsf/mf/2033.0.55.001. Accessed 3 June 2016
  39. 39.
    Huang CS, Chuang CH, Lo TF, Hu ML (2013) Anti-angiogenic effects of lycopene through immunomodulation of cytokine secretion in human peripheral blood mononuclear cells. J Nutr Biochem 24(2):428–434.  https://doi.org/10.1016/j.jnutbio.2012.01.003 CrossRefPubMedGoogle Scholar
  40. 40.
    Chen M-L, Lin Y-H, Yang C-M, Hu M-L (2012) Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways. Mol Nutr Food Res 56(6):889–899.  https://doi.org/10.1002/mnfr.201100683 CrossRefPubMedGoogle Scholar
  41. 41.
    Liu RH (3485S) Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr 134(12 Suppl):3479S–3485S.  https://doi.org/10.1093/jn/134.12.3479S CrossRefPubMedGoogle Scholar
  42. 42.
    Steinmetz KA, Potter JD (1991) Vegetables, fruit, and cancer. II. Mechanisms. Cancer Causes Control 2(6):427–442CrossRefGoogle Scholar
  43. 43.
    Dashwood RH, Myzak MC, Ho E (2006) Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention? Carcinogenesis 27(2):344–349CrossRefGoogle Scholar
  44. 44.
    Vivar OI, Lin C-L, Firestone GL, Bjeldanes LF (2009) 3,3′-Diindolylmethane induces a G1 arrest in human prostate cancer cells irrespective of androgen receptor and p53 status. Biochem Pharmacol 78(5):469–476.  https://doi.org/10.1016/j.bcp.2009.05.008 CrossRefPubMedPubMedCentralGoogle Scholar
  45. 45.
    Kolonel LN, Hankin JH, Whittemore AS, Wu AH, Gallagher RP, Wilkens LR et al (2000) Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Cancer Epidemiol Biomark Prev 9(8):795–804Google Scholar
  46. 46.
    Cohen JH, Kristal AR, Stanford JL (2000) Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst 92(1):61–68CrossRefGoogle Scholar
  47. 47.
    World Cancer Research Fund/American Institute for Cancer Research (2011) Continuous update project report. Food, nutrition, physical activity, and the prevention of colorectal cancerGoogle Scholar
  48. 48.
    Bouvard V, Loomis D, Guyton KZ, Grosse Y, Ghissassi FE, Benbrahim-Tallaa L et al (2015) Carcinogenicity of consumption of red and processed meat. Lancet Oncol 16(16):1599–1600.  https://doi.org/10.1016/S1470-2045(15)00444-1 CrossRefPubMedGoogle Scholar
  49. 49.
    Diallo A, Deschasaux M, Latino-Martel P, Hercberg S, Galan P, Fassier P et al (2018) Red and processed meat intake and cancer risk: results from the prospective NutriNet-Santé cohort study: red and processed meat intake and cancer risk. Int J Cancer 142(2):230–237.  https://doi.org/10.1002/ijc.31046 CrossRefPubMedGoogle Scholar
  50. 50.
    Fradet V, Cheng I, Casey G, Witte JS (2009) Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk. Clin Cancer Res 15(7):2559–2566.  https://doi.org/10.1158/1078-0432.CCR-08-2503 CrossRefPubMedPubMedCentralGoogle Scholar
  51. 51.
    Pelser C, Mondul AM, Hollenbeck AR, Park Y (2013) Dietary fat, fatty acids, and risk of prostate cancer in the NIH-AARP diet and health study. Cancer Epidemiol Biomark Prev 22(4):697–707.  https://doi.org/10.1158/1055-9965.EPI-12-1196-T CrossRefGoogle Scholar
  52. 52.
    Leitzmann MF, Stampfer MJ, Michaud DS, Augustsson K, Colditz GC, Willett WC et al (2004) Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. Am J Clin Nutr 80(1):204–216CrossRefGoogle Scholar
  53. 53.
    Liang P, Henning SM, Schokrpur S, Wu L, Doan N, Said J et al (2016) Effect of dietary omega-3 fatty acids on tumor-associated macrophages and prostate cancer progression: fish oil and tumor-associated macrophages. Prostate 76(14):1293–1302.  https://doi.org/10.1002/pros.23218 CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Saw CL, Wu TY, Paredes-Gonzalez X, Khor TO, Pung D, Kong AN (2011) Pharmacodynamics of fish oil: protective effects against prostate cancer in TRAMP mice fed with a high fat western diet. Asian Pac J Cancer Prev 12(12):3331–3334PubMedGoogle Scholar
  55. 55.
    Lloyd JC, Masko EM, Wu C, Keenan MM, Pilla DM, Aronson WJ et al (2013) Fish oil slows prostate cancer xenograft growth relative to other dietary fats and is associated with decreased mitochondrial and insulin pathway gene expression. Prostate Cancer Prostatic Dis 16(4):285–291.  https://doi.org/10.1038/pcan.2013.19 CrossRefPubMedPubMedCentralGoogle Scholar
  56. 56.
    Meng H, Shen Y, Shen J, Zhou F, Shen S, Das UN (2013) Effect of n-3 and n-6 unsaturated fatty acids on prostate cancer (PC-3) and prostate epithelial (RWPE-1) cells in vitro. Lipids Health Dis 12(1):160.  https://doi.org/10.1186/1476-511X-12-160 CrossRefPubMedPubMedCentralGoogle Scholar
  57. 57.
    Liu Z, Hopkins MM, Zhang Z, Quisenberry CB, Fix LC, Galvan BM et al (2015) Omega-3 fatty acids and other FFA4 agonists inhibit growth factor signaling in human prostate cancer cells. J Pharmacol Exp Ther 352(2):380–394.  https://doi.org/10.1124/jpet.114.218974 CrossRefPubMedPubMedCentralGoogle Scholar
  58. 58.
    Chan JM, Stampfer MJ, Ma J, Gann PH, Gaziano JM, Giovannucci EL (2001) Dairy products, calcium, and prostate cancer risk in the Physicians’ Health Study. Am J Clin Nutr 74(4):549–554CrossRefGoogle Scholar
  59. 59.
    Michaud DS, Augustsson K, Rimm EB, Stampfer MJ, Willett WC, Giovannucci E (2001) A prospective study on intake of animal products and risk of prostate cancer. Cancer Causes Control 12(6):557–567CrossRefGoogle Scholar
  60. 60.
    Hodge AM, English DR, McCredie MRE, Severi G, Boyle P, Hopper JL et al (2004) Foods, nutrients and prostate cancer. Cancer Causes Control 15(1):11–20CrossRefGoogle Scholar
  61. 61.
    Rodriguez C, McCullough ML, Mondul AM, Jacobs EJ, Fakhrabadi-Shokoohi D, Giovannucci EL et al (2003) Calcium, dairy products, and risk of prostate cancer in a prospective cohort of United States men. Cancer Epidemiol Prev Biomark 12(7):597–603Google Scholar
  62. 62.
    Koh KA, Sesso HD, Paffenbarger RS, Lee I-M (2006) Dairy products, calcium and prostate cancer risk. Br J Cancer 95(11):1582–1585CrossRefGoogle Scholar
  63. 63.
    World Cancer Research Fund/American Institute for Cancer Research (2018) Meat, fish and dairy products and the risk of cancer: continuous update project expert report 2018. https://dietandcancerreport.org
  64. 64.
    Ahn J, Albanes D, Peters U, Schatzkin A, Lim U, Freedman M et al (2007) Dairy products, calcium intake, and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomark Prev 16(12):2623–2630CrossRefGoogle Scholar
  65. 65.
    Littlejohns TJ, Travis RC, Key TJ, Allen NE (2016) Lifestyle factors and prostate-specific antigen (PSA) testing in UK Biobank: implications for epidemiological research. Cancer Epidemiol 45:40–46.  https://doi.org/10.1016/j.canep.2016.09.010 CrossRefPubMedPubMedCentralGoogle Scholar
  66. 66.
    Pernar CH, Ebot EM, Wilson KM, Mucci LA (2018) The epidemiology of prostate cancer. Cold Spring Harb Perspect Med.  https://doi.org/10.1101/cshperspect.a030361 CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Karolinska InstituteStockholmSweden
  2. 2.Cancer Epidemiology DivisionCancer Council VictoriaMelbourneAustralia
  3. 3.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global HealthUniversity of MelbourneParkvilleAustralia
  4. 4.Department of Surgery, Austin HealthThe University of MelbourneMelbourneAustralia
  5. 5.Olivia Newton-John Cancer and Wellness Centre, Austin HealthHeidelbergAustralia
  6. 6.Monash UniversityMelbourneAustralia
  7. 7.Eastern HealthBox HillAustralia
  8. 8.Alfred Health Radiation OncologyAlfred HospitalMelbourneAustralia
  9. 9.Department of Surgery, Central Clinical SchoolMonash University, The Alfred CentreMelbourneAustralia
  10. 10.Centre de Recherche en Épidémiologie et Santé des Populations (CESP, Inserm U1018), Facultés de MédecineUniversité Paris-Saclay, UPS UVSQ, Gustave RoussyVillejuifFrance
  11. 11.Precision Medicine, School of Clinical Sciences at Monash HealthMonash UniversityClaytonAustralia
  12. 12.Genetic Epidemiology Laboratory, Department of Clinical PathologyUniversity of MelbourneParkvilleAustralia

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