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Interplay between exercise and BMI; results from an equal access, racially diverse biopsy study

  • Jamie Michael
  • Taofik Oyekunle
  • Lauren Howard
  • Amanda De Hoedt
  • Catherine Hoyo
  • Delores Grant
  • Stephen Freedland
Original paper
  • 7 Downloads

Abstract

Purpose

It is unclear if exercise and BMI interact to influence prostate cancer (PC) risk. We hypothesized BMI is linked with increased aggressive PC risk but this link will be attenuated with increased exercise.

Methods

Men undergoing prostate biopsy completed a questionnaire and metabolic equivalent (MET) hours of exercise was calculated. Of 695 men, 349 had PC; 161 low-grade, and 188 high-grade. We assessed the link between exercise and PC risk, high-grade PC (Gleason 7–10), and low-grade PC (Gleason 2–6) using logistic and multinomial logistic regression. Analysis was stratified by BMI. Link between BMI and PC risk and aggressive PC was similarly tested.

Results

On multivariable analysis, there was no link between exercise and PC diagnosis in the entire cohort (p trend = 0.18–0.71) or across BMI groups (p trend = 0.15–0.97). For the entire cohort, higher BMI was linked with increased risk of high-grade PC (OR 1.06, p = 0.008). When stratified by exercise groups, the trend for higher BMI and increased risk of high-grade PC remained (OR 1.03–1.15, p = 0.02–0.66). There were no interactions between exercise and BMI in predicting PC risk (all p ≥ 0.31).

Conclusions

Regardless of exercise, higher BMI was linked with higher risk of aggressive PC, while exercise was unrelated to PC risk. Confirmatory studies are needed.

Keywords

Prostate biopsy Exercise BMI Veterans Prostate cancer 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare no potential conflicts of interest.

Supplementary material

10552_2018_1104_MOESM1_ESM.docx (48 kb)
Supplementary material 1 (DOCX 47 KB)

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Jamie Michael
    • 1
  • Taofik Oyekunle
    • 2
  • Lauren Howard
    • 2
  • Amanda De Hoedt
    • 1
  • Catherine Hoyo
    • 3
  • Delores Grant
    • 4
  • Stephen Freedland
    • 1
    • 5
  1. 1.Division of UrologyVeterans Affairs Medical CenterDurhamUSA
  2. 2.Duke Cancer InstituteDuke University School of MedicineDurhamUSA
  3. 3.Epidemiology and Environmental EpigenomicsNorth Carolina State UniversityRaleighUSA
  4. 4.Department of Biological and Biomedical SciencesNC Central UniversityDurhamUSA
  5. 5.Cedars-Sinai Medical CenterLos AngelesUSA

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