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Cancer Causes & Control

, Volume 30, Issue 1, pp 1–12 | Cite as

Habitual recreational physical activity is associated with significantly improved survival in cancer patients: evidence from the Roswell Park Data Bank and BioRepository

  • Rikki A. CanniotoEmail author
  • Shruti Dighe
  • Martin C. Mahoney
  • Kirsten B. Moysich
  • Arindam Sen
  • Karen Hulme
  • Susan E. McCann
  • Christine B. Ambrosone
Original paper

Abstract

Purpose

The association of recreational physical activity (RPA) with mortality is well established only for breast and colon cancers and few studies have evaluated relationships for exercising before and after diagnosis, across multiple disease sites. We examined the joint associations of pre- and post- diagnosis RPA with mortality in a cohort of 5,807 patients enrolled in the Data Bank and BioRepository at Roswell Park.

Methods

Patients were classified into one of four activity categories (habitually active, increased activity after diagnosis, decreased activity after diagnosis, habitually inactive). Cox proportional hazards models were used to estimate the associations of activity status with mortality.

Results

In comparison to patients who were habitually inactive, habitually active patients experienced a 39% decreased hazard of all-cause mortality (HR = 0.61, 95% CI 0.54–0.69) and a 36% decreased hazard of cancer-specific mortality (HR = 0.64, 95% CI 0.56–0.73). Previously inactive patients who began exercising after diagnosis experienced a 28% decreased hazard of all-cause (HR = 0.72, 95% CI 0.59–0.89) and cancer-specific mortality (HR = 0.72, 95% CI 0.57–0.91) in comparison to patients who remained inactive. Patients engaging in 3–4 sessions/week experienced the greatest survival advantages, but 1–2 sessions/week also yielded significant survival advantages in comparison to inactivity.

Conclusion

Low-to-moderate frequency pre- and post-diagnosis RPA was associated with significantly decreased mortality in patients diagnosed with a variety of malignancies. These observations solidify the clinical and public health importance of the message that some regular activity is better than inactivity, which is particularly encouraging, given that cancer survivors can be overwhelmed by current daily physical activity recommendations.

Keywords

Physical activity Survival Mortality 

Abbreviations

RPA

Recreational physical activity

MVPA

Moderate-to-vigorous intensity physical activity

BMI

Body mass index

DBBR

Data Bank and BioRepository

Notes

Funding

The study was funded in part by the Roswell Park Cancer Center Support Grant Shared Resource, supported by the National Cancer Institute Grant P30CA016056; Arinden Sen is supported by NIH R21CA194634 (AS).

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest.

Ethical approval

The research described herein was approved by Roswell Park’s IRB. Thus, all procedures and analyses performed were in accordance with the ethical standards of Roswell Park and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all participants included in the DBBR study.

Supplementary material

10552_2018_1101_MOESM1_ESM.docx (45 kb)
Supplementary material 1 (DOCX 45 KB)

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Rikki A. Cannioto
    • 1
    Email author
  • Shruti Dighe
    • 1
    • 2
  • Martin C. Mahoney
    • 3
  • Kirsten B. Moysich
    • 1
  • Arindam Sen
    • 4
    • 5
  • Karen Hulme
    • 1
  • Susan E. McCann
    • 1
  • Christine B. Ambrosone
    • 1
  1. 1.Department of Cancer Prevention and ControlRoswell Park Comprehensive Cancer CenterBuffaloUSA
  2. 2.Department of Epidemiology and Environmental HealthUniversity at BuffaloBuffaloUSA
  3. 3.Department of MedicineRoswell Park Comprehensive Cancer CenterBuffaloUSA
  4. 4.Department of Cell Stress BiologyRoswell Park Comprehensive Cancer CenterBuffaloUSA
  5. 5.Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloUSA

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