Cancer Causes & Control

, Volume 29, Issue 4–5, pp 427–433 | Cite as

Hysterectomy-corrected rates of endometrial cancer among women younger than age 50 in the United States

  • Sarah M. Temkin
  • Elise C. Kohn
  • Lynne Penberthy
  • Kathleen A. Cronin
  • Lisa Rubinsak
  • Lois A. Dickie
  • Lori Minasian
  • Anne-Michelle Noone
Original paper

Abstract

Purpose

This analysis describes the impact of hysterectomy on incidence rates and trends in endometrioid endometrial cancer in the United States among women of reproductive age.

Methods

Hysterectomy prevalence for states containing Surveillance, Epidemiology, and End Results (SEER) registry was estimated using data from the Behavioral Risk Factor Surveillance System (BRFSS) between 1992 and 2010. The population was adjusted for age, race, and calendar year strata. Age-adjusted incidence rates and trends of endometrial cancer among women age 20–49 corrected for hysterectomy were estimated.

Results

Hysterectomy prevalence varied by age, race, and ethnicity. Increasing incidence trends were observed, and were attenuated after correcting for hysterectomy. Among all women, the incidence was increasing 1.6% annually (95% CI 0.9, 2.3) and this increase was no longer significant after correction for hysterectomy (+ 0.7; 95% CI − 0.1, 1.5). Stage at diagnosis was similar with and without correction for hysterectomy. The largest increase in incidence over time was among Hispanic women; even after correction for hysterectomy, incidence was increasing (1.8%; 95% CI 0.2, 3.4) annually.

Conclusion

Overall, endometrioid endometrial cancer incidence rates in the US remain stable among women of reproductive age. Routine reporting of endometrial cancer incidence does not accurately measure incidence among racial and ethnic minorities.

Keywords

Endometrial cancer incidence Hysterectomy Disparities 

Notes

Acknowledgments

This work was presented in part at the Meeting of the International Gynecologic Cancer Society in Lisbon, Portugal, in October 2016. The authors thank T Gibson and S Scoppa from Information Management Systems, Inc, for their assistance with data management.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Gynecologic OncologyVirginia Commonwealth UniversityRichmondUSA
  2. 2.Cancer Therapy Evaluation Program, National Cancer InstituteNational Institutes of HealthBethesdaUSA
  3. 3.Division of Cancer Control & Population Sciences, National Cancer InstituteNational Institutes of HealthBethesdaUSA
  4. 4.Division of Cancer Prevention, National Cancer InstituteNational Institutes of HealthBethesdaUSA
  5. 5.Department of Obstetrics and GynecologyVirginia Commonwealth UniversityRichmondUSA

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