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Cancer Causes & Control

, Volume 28, Issue 2, pp 107–115 | Cite as

Helicobacter pylori infection is an independent risk factor for colonic adenomatous neoplasms

  • Ji Hyung Nam
  • Chang Won HongEmail author
  • Byung Chang Kim
  • Aesun Shin
  • Kum Hei Ryu
  • Bum Joon Park
  • Bun Kim
  • Dae Kyung Sohn
  • Kyung Su Han
  • Jeongseon Kim
  • Chan Wha Lee
Original paper

Abstract

Purpose

Helicobacter pylori infection is considered to have a positive association with colorectal neoplasms. In this study, we evaluated the association between H. pylori infection and colorectal adenomas, based on the characteristics of these adenomas in Korea, where the prevalence of H. pylori infection is high and the incidence of colorectal cancer continues to increase.

Methods

The study cohort consisted of 4,466 subjects who underwent colonoscopy and esophagogastroduodenoscopy during screening (1,245 colorectal adenomas vs. 3,221 polyp-free controls). We compared the rate of H. pylori infection between patients with adenoma and polyp-free control cases, using multivariable logistic regression analysis.

Results

The overall rate of positive H. pylori infection was higher in adenoma cases than in polyp-free control cases (55.0 vs. 48.5%, p < 0.001). The odds ratio (OR) of positive H. pylori infection in patients with adenoma compared to polyp-free controls was 1.28 (95% CI 1.11–1.47). The positive association of H. pylori infection with colorectal adenomas was more prominent in advanced adenomas (OR 1.84, 95% CI 1.25–2.70) and multiple adenomas (OR 1.72, 95% CI 1.26–2.35). Based on the location of these adenomas, the OR was significant only in patients with colonic adenomas (OR 1.31, 95% CI 1.13–1.52) and not in those with rectal adenoma (OR 0.85, 95% CI 0.58–1.24).

Conclusion

Helicobacter pylori infection is an independent risk factor for colonic adenomas, especially in cases of advanced or multiple adenomas, but not for rectal adenomas.

Keywords

H. Pylori Adenoma Colonoscopy Risk factor 

Notes

Acknowledgments

This study was supported in part by Grants NCC-1410250-3, NCC-1610250, and NCC-0910221 from National Cancer Center, Korea. The authors thank Jeong-Hee Lee, MS for their help in manuscript preparation.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Ji Hyung Nam
    • 1
  • Chang Won Hong
    • 1
    • 2
    Email author
  • Byung Chang Kim
    • 1
    • 2
  • Aesun Shin
    • 3
    • 4
  • Kum Hei Ryu
    • 1
  • Bum Joon Park
    • 1
  • Bun Kim
    • 1
    • 2
  • Dae Kyung Sohn
    • 1
    • 2
  • Kyung Su Han
    • 1
    • 2
  • Jeongseon Kim
    • 4
  • Chan Wha Lee
    • 1
  1. 1.Center for Cancer Prevention and DetectionNational Cancer CenterGoyang-siRepublic of Korea
  2. 2.Center for Colorectal CancerNational Cancer CenterGoyang-siRepublic of Korea
  3. 3.Department of Preventive MedicineSeoul National University College of MedicineSeoulRepublic of Korea
  4. 4.Molecular Epidemiology Branch, Research InstituteNational Cancer CenterGoyang-siRepublic of Korea

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