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Cancer Causes & Control

, Volume 27, Issue 11, pp 1325–1332 | Cite as

Endocrine therapy and urogenital outcomes among women with a breast cancer diagnosis

  • Suzanne N. Landi
  • Kemi M. Doll
  • Jeannette T. Bensen
  • Laura Hendrix
  • Carey K. Anders
  • Jennifer M. Wu
  • Hazel B. Nichols
Original Paper

Abstract

Purpose

Endocrine therapy for breast cancer can exacerbate menopausal symptoms. The association between endocrine therapy and common pelvic floor disorders including urinary incontinence has rarely been evaluated. We examined urogenital and sexual side effects among women with a breast cancer diagnosis, comparing endocrine therapy users to nonusers.

Methods

Urogenital and sexual symptoms were self-reported during the enrollment interview within the University of North Carolina Cancer Survivorship Cohort. Tumor characteristics and endocrine therapy use were collected from medical and prescription records. We calculated multivariable prevalence ratios (PR) and 95 % confidence intervals (CI) for the association of endocrine therapy (versus no endocrine therapy) and urinary incontinence, overall and by therapy type (tamoxifen or aromatase inhibitors). PROMIS Sexual Function and Satisfaction domain scores were compared across endocrine therapy groups.

Results

Among the 548 women with a breast cancer diagnosis, 49 % received endocrine therapy. Overall, 18 % of women reported urinary incontinence symptoms. We observed no association between urinary incontinence and endocrine therapy use overall (PR = 0.97; 95 % CI 0.67, 1.43), tamoxifen (PR = 1.20; 95 % CI 0.74, 1.96), or aromatase inhibitors (PR = 0.89; 95 % CI 0.55, 1.42), compared to no use. Approximately 55 % of women were sexually active. Sexual function scores did not vary according to endocrine therapy use, although urinary incontinence was associated with lower satisfaction scores (p = 0.05).

Conclusions

Our findings demonstrate a high prevalence of urinary incontinence after breast cancer diagnosis similar to the overall prevalence in older U.S. women, and this did not vary strongly according to use of endocrine therapy.

Keywords

Endocrine therapy Cancer survivors Patient-reported outcomes Urinary incontinence Sexual function 

Notes

Acknowledgments

The authors thank the UNC Health Registry/Cancer Survivorship Cohort (HR/CSC) participants for their important contributions and appreciate the helpful comments of Dr. Antonia Bennett. The UNC HR/CSC is funded in part by the UNC Lineberger Comprehensive Cancer Center’s University Cancer Research Fund.

Compliance with ethical standards

Funding

This research was supported in part by the National Center for Advancing Translational Sciences (KL2-TR001109).

Conflict of interest

Dr. Jennifer Wu has received institutional research grants from Boston Scientific and Pelvalon. The remaining authors declare that they have no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Suzanne N. Landi
    • 1
  • Kemi M. Doll
    • 2
    • 3
  • Jeannette T. Bensen
    • 1
    • 3
  • Laura Hendrix
    • 3
  • Carey K. Anders
    • 3
  • Jennifer M. Wu
    • 4
  • Hazel B. Nichols
    • 1
  1. 1.Department of Epidemiology, Gillings School of Global Public HealthUniversity of North Carolina at Chapel HillChapel HillUSA
  2. 2.Department of Health Policy and Management, Gillings School of Global Public HealthUniversity of North Carolina at Chapel HillChapel HillUSA
  3. 3.Lineberger Comprehensive Cancer Center, School of MedicineUniversity of North Carolina at Chapel HillChapel HillUSA
  4. 4.Department of Obstetrics and Gynecology, School of MedicineUniversity of North Carolina at Chapel HillChapel HillUSA

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