Active smoking and risk of Luminal and Basal-like breast cancer subtypes in the Carolina Breast Cancer Study
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Growing evidence suggests an association between active cigarette smoking and increased breast cancer risk. However, the weak magnitude of association and conflicting results have yielded uncertainty and it is unknown whether associations differ by breast cancer subtype.
Using population-based case–control data from phases I and II of the Carolina Breast Cancer Study, we examined associations between self-reported measures of smoking and risk of Luminal and Basal-like breast cancers. We used logistic regression models to estimate case–control odds ratios (OR) and 95 % confidence intervals (CI).
Ever smoking (current and former) was associated with a weakly increased risk of Luminal breast cancer (OR 1.12, 95 % CI 0.92–1.36) and was not associated with risk of Basal-like breast cancer (OR 0.96, 95 % CI 0.69–1.32). Similarly, smoking duration of more than 20 years was associated with increased risk of Luminal (OR 1.51, 95 % CI 1.19–1.93), but not Basal-like breast cancer (OR 0.90, 95 % CI 0.57–1.43). When stratified by race, elevated odds ratios between smoking and Luminal breast cancer risk were found among black women across multiple exposure measures (ever smoking, duration, and dose); conversely, among white women odds ratios were attenuated or null.
Results from our study demonstrate a positive association between smoking and Luminal breast cancer risk, particularly among black women and women with long smoking histories. Addressing breast cancer heterogeneity in studies of smoking and breast cancer risk may elucidate associations masked in prior studies.
KeywordsSmoking Breast cancer Estrogen receptor Luminal Basal-like Race
This work was supported by the North Carolina University Cancer Research Fund, a Grant from the Komen Foundation, and a National Cancer Institute Specialized Program of Research Excellence Grant, P50-CA058223.
- 1.Alberg AJ, Shopland DR, Cummings KM (2014) The 2014 Surgeon General’s report: commemorating the 50th anniversary of the 1964 report of the advisory committee to the US Surgeon General and updating the evidence on the health consequences of cigarette smoking. Am J Epidemiol 179(4):403–412. doi: 10.1093/aje/kwt335 CrossRefPubMedPubMedCentralGoogle Scholar
- 4.Palmer JR, Viscidi E, Troester MA, Hong CC, Schedin P, Bethea TN, Bandera EV, Borges V, McKinnon C, Haiman CA, Lunetta K, Kolonel LN, Rosenberg L, Olshan AF, Ambrosone CB (2014) Parity, lactation, and breast cancer subtypes in African American women: results from the AMBER Consortium. J Natl Cancer Inst. doi: 10.1093/jnci/dju237 Google Scholar
- 5.Terry PD, Rohan TE (2002) Cigarette smoking and the risk of breast cancer in women a review of the literature. Cancer Epidemiol Biomark Prev 11(10):953–971Google Scholar
- 11.Chen CS, Lee CH, Hsieh CD, Ho CT, Pan MH, Huang CS, Tu SH, Wang YJ, Chen LC, Chang YJ, Wei PL, Yang YY, Wu CH, Ho YS (2011) Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins. Breast Cancer Res Treat 125(1):73–87. doi: 10.1007/s10549-010-0821-3 CrossRefPubMedGoogle Scholar
- 13.Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, Demeter J, Perou CM, Lonning PE, Brown PO, Borresen-Dale AL, Botstein D (2003) Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA 100(14):8418–8423. doi: 10.1073/pnas.0932692100 CrossRefPubMedPubMedCentralGoogle Scholar
- 14.Parker JS, Mullins M, Cheang MC, Leung S, Voduc D, Vickery T, Davies S, Fauron C, He X, Hu Z, Quackenbush JF, Stijleman IJ, Palazzo J, Marron JS, Nobel AB, Mardis E, Nielsen TO, Ellis MJ, Perou CM, Bernard PS (2009) Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol 27(8):1160–1167. doi: 10.1200/JCO.2008.18.1370 CrossRefPubMedPubMedCentralGoogle Scholar
- 15.Millikan RC, Newman B, Tse CK, Moorman PG, Conway K, Dressler LG, Smith LV, Labbok MH, Geradts J, Bensen JT, Jackson S, Nyante S, Livasy C, Carey L, Earp HS, Perou CM (2008) Epidemiology of basal-like breast cancer. Breast Cancer Res Treat 109(1):123–139. doi: 10.1007/s10549-007-9632-6 CrossRefPubMedPubMedCentralGoogle Scholar
- 17.Kabat GC, Kim M, Phipps AI, Li CI, Messina CR, Wactawski-Wende J, Kuller L, Simon MS, Yasmeen S, Wassertheil-Smoller S, Rohan TE (2011) Smoking and alcohol consumption in relation to risk of triple-negative breast cancer in a cohort of postmenopausal women. Cancer Causes Control CCC 22(5):775–783. doi: 10.1007/s10552-011-9750-7 CrossRefPubMedPubMedCentralGoogle Scholar
- 22.Carey LA, Perou CM, Livasy CA, Dressler LG, Cowan D, Conway K, Karaca G, Troester MA, Tse CK, Edmiston S, Deming SL, Geradts J, Cheang MC, Nielsen TO, Moorman PG, Earp HS, Millikan RC (2006) Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA 295(21):2492–2502. doi: 10.1001/jama.295.21.2492 CrossRefPubMedGoogle Scholar
- 24.Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, Hernandez-Boussard T, Livasy C, Cowan D, Dressler L, Akslen LA, Ragaz J, Gown AM, Gilks CB, van de Rijn M, Perou CM (2004) Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 10(16):5367–5374. doi: 10.1158/1078-0432.CCR-04-0220 CrossRefPubMedGoogle Scholar
- 37.Mechanic LE, Millikan RC, Player J, de Cotret AR, Winkel S, Worley K, Heard K, Heard K, Tse CK, Keku T (2006) Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case–control study. Carcinogenesis 27(7):1377–1385. doi: 10.1093/carcin/bgi330 CrossRefPubMedGoogle Scholar
- 40.Soulakova JN, Hartman AM, Liu B, Willis GB, Augustine S (2012) Reliability of adult self-reported smoking history: data from the tobacco use supplement to the current population survey 2002–2003 cohort. Nicotine Tob Res 14(8):952–960. doi: 10.1093/ntr/ntr313 CrossRefPubMedPubMedCentralGoogle Scholar
- 41.Studts JL, Ghate SR, Gill JL, Studts CR, Barnes CN, LaJoie AS, Andrykowski MA, LaRocca RV (2006) Validity of self-reported smoking status among participants in a lung cancer screening trial. Cancer Epidemiol Biomarkers Prev 15(10):1825–1828. doi: 10.1158/1055-9965.EPI-06-0393 CrossRefPubMedGoogle Scholar
- 43.Centers for Disease C, Prevention (1996) State-specific prevalence of cigarette smoking—United States, 1995. MMWR Morb Mortal Wkly Rep 45(44):962–966Google Scholar