Cancer Causes & Control

, Volume 26, Issue 10, pp 1365–1373 | Cite as

Impact of pre-diagnosis behavior on risk of death from esophageal cancer: a systematic review and meta-analysis

  • Paul P. Fahey
  • Kylie-Ann Mallitt
  • Thomas Astell-Burt
  • Glenn Stone
  • David C. Whiteman
Review article

Abstract

Purpose

Most people diagnosed with esophageal cancer will die from their disease, but it is not known whether survival is influenced by pre-morbid behavior. We undertook a systematic review and meta-analysis to investigate the impact of pre-diagnosis behavior on risk of death for esophageal cancer.

Methods

We performed a systematic review of studies reporting on the relationship between pre-diagnosis smoking, alcohol consumption, overweight and obesity, physical activity and regular consumption of nonsteroidal anti-inflammatory drugs, and risk of death from esophageal squamous cell carcinoma (ESCC) and adenocarcinomas (EACs). Study characteristics are presented and aggregate results are compiled using meta-analysis.

Results

From an initial pool of 644 non-duplicate records, 13 articles arising from 12 studies met the inclusion criteria. Considerable variation was observed between studies in location, measurement categories, adjustment for other risks, and results. Pooled estimates suggested that for ESCC pre-diagnosis smoking was associated with a 1.19 times [95 % confidence interval (CI) 1.04–1.36] increased risk of death and pre-diagnosis alcohol consumption with a 1.36 times increased risk of death (95 % CI 1.15–1.61). No significant effects were observed for EAC. We observed a lower risk of death for both ESCC and EAC associated with high pre-diagnosis body mass index (BMI) ≥25 kg/m2 (ESCC hazard ratio 0.80, 95 % CI 0.67–0.95; EAC 0.80, 95 % CI 0.68–0.95), although there was significant heterogeneity across studies.

Conclusions

Our findings suggest that a number of modifiable pre-diagnosis risk factors have a carryover effect on the risk of death from esophageal cancer. These include smoking, drinking alcohol, and BMI.

Keywords

Esophageal squamous cell carcinoma Esophageal adenocarcinoma Risk of death Health behavior 

Supplementary material

10552_2015_635_MOESM1_ESM.pdf (326 kb)
PubMed search criteria and additional results arising from the meta-analyses (PDF 325 kb)

References

  1. 1.
    World Cancer Research Fund/American Institute for Cancer Research (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. AICR, WashingtonGoogle Scholar
  2. 2.
    Hongo M, Nagasaki Y, Shoji T (2009) Epidemiology of esophageal cancer: orient to occident. Effects of chronology, geography and ethnicity. J Gastroenterol Hepatol 24(5):729–735CrossRefPubMedGoogle Scholar
  3. 3.
    American Cancer Society (2011) Global cancer facts & figures, 2nd edn. American Cancer Society, AtlantaGoogle Scholar
  4. 4.
    Corley DA, Kerlikowske K, Verma R, Buffler P (2003) Protective association of aspirin/NSAIDs and esophageal cancer: a systematic review and meta-analysis. Gastroenterology 124(1):47–56CrossRefPubMedGoogle Scholar
  5. 5.
    Friedenreich CM, Neilson HK, Lynch BM (2010) State of the epidemiological evidence on physical activity and cancer prevention. Eur J Cancer 46(14):2593–2604CrossRefPubMedGoogle Scholar
  6. 6.
    Demark-Wahnefried W, Aziz NM, Rowland JH, Pinto BM (2005) Riding the crest of the teachable moment: promoting long-term health after the diagnosis of cancer. J Clin Oncol 23(24):5814–5830CrossRefPubMedCentralPubMedGoogle Scholar
  7. 7.
    National Center for Health Statistics (2014) Health, United States, 2013: with special feature on prescription drugs. National Center for Health Statistics, HyattsvilleGoogle Scholar
  8. 8.
    Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA 283(15):2008–2012CrossRefPubMedGoogle Scholar
  9. 9.
    Jüni P, Witschi A, Bloch R, Egger M (1999) The hazards of scoring the quality of clinical trials for meta-analysis. JAMA 282(11):1054–1060CrossRefPubMedGoogle Scholar
  10. 10.
    Borenstein M, Hedges LV, Higgins JP, Rothstein HR (2009) Introduction to meta-analysis. Wiley, ChichesterCrossRefGoogle Scholar
  11. 11.
    Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557CrossRefPubMedCentralPubMedGoogle Scholar
  12. 12.
    Park SM, Lim MK, Shin SA, Yun YH (2006) Impact of prediagnosis smoking, alcohol, obesity, and insulin resistance on survival in male cancer patients: National Health Insurance Corporation Study. J Clin Oncol 24(31):5017–5024. doi:10.1200/jco.2006.07.0243 CrossRefPubMedGoogle Scholar
  13. 13.
    Sundelöf M, Lagergren J, Ye W (2008) Patient demographics and lifestyle factors influencing long-term survival of oesophageal cancer and gastric cardia cancer in a nationwide study in Sweden. Eur J Cancer 44(11):1566–1571CrossRefPubMedGoogle Scholar
  14. 14.
    Thrift A, Nagle C, Fahey P, Smithers B, Watson D, Whiteman D (2012) Predictors of survival among patients diagnosed with adenocarcinoma of the esophagus and gastroesophageal junction. Cancer Causes Control 23(4):555–564. doi:10.1007/s10552-012-9913-1 CrossRefPubMedGoogle Scholar
  15. 15.
    Thrift AP, Nagle CM, Fahey PP, Russell A, Smithers BM, Watson DI, Whiteman DC, for the Australian Cancer Study Clinical Follow-Up S (2012) The influence of prediagnostic demographic and lifestyle factors on esophageal squamous cell carcinoma survival. Int J Cancer. doi:10.1002/ijc.27420 PubMedCentralGoogle Scholar
  16. 16.
    Trivers KF, de Roos AJ, Gammon MD, Vaughan TL, Risch HA, Olshan AF, Schoenberg JB, Mayne ST, Dubrow R, Stanford JL, Abrahamson P, Rotterdam H, West AB, Fraumeni JF Jr, Chow W-H (2005) Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers. Clin Gastroenterol Hepatol 3(3):225–230CrossRefPubMedGoogle Scholar
  17. 17.
    Aghcheli K, Marjani HA, Nasrollahzadeh D, Islami F, Shakeri R, Sotoudeh M, Abedi-Ardekani B, Ghavamnasiri MR, Razaei E, Khalilipour E (2011) Prognostic factors for esophageal squamous cell carcinoma—a population-based study in Golestan Province, Iran, a high incidence area. PLoS One 6(7):e22152CrossRefPubMedCentralPubMedGoogle Scholar
  18. 18.
    Jing C, Huang Z, Duan Y, Xiao X, Zhang R, Jiang J (2012) Folate intake, methylenetetrahydrofolate reductase polymorphisms in association with the prognosis of esophageal squamous cell carcinoma. Asian Pac J Cancer Prev 13:647–651CrossRefPubMedGoogle Scholar
  19. 19.
    Sehgal S, Kaul S, Gupta B, Dhar M (2012) Risk factors and survival analysis of the esophageal cancer in the population of Jammu, India. Indian J Cancer 49(2):245CrossRefPubMedGoogle Scholar
  20. 20.
    Shitara K, Matsuo K, Hatooka S, Ura T, Takahari D, Yokota T, Abe T, Kawai H, Tajika M, Kodaira T (2010) Heavy smoking history interacts with chemoradiotherapy for esophageal cancer prognosis: a retrospective study. Cancer Sci 101(4):1001–1006CrossRefPubMedGoogle Scholar
  21. 21.
    Wu X, Chen VW, Andrews PA, Ruiz B, Correa P (2007) Incidence of esophageal and gastric cancers among Hispanics, non-Hispanic Whites and non-Hispanic Blacks in the United States: subsite and histology differences. Cancer Causes Control 18(6):585–593CrossRefPubMedGoogle Scholar
  22. 22.
    Cescon DW, Bradbury PA, Asomaning K, Hopkins J, Zhai R, Zhou W, Wang Z, Kulke M, Su L, Ma C (2009) p53 Arg72Pro and MDM2 T309G polymorphisms, histology, and esophageal cancer prognosis. Clin Cancer Res 15(9):3103–3109CrossRefPubMedCentralPubMedGoogle Scholar
  23. 23.
    Samadi F, Babaei M, Yazdanbod A, Fallah M, Nouraie M, Nasrollahzadeh D, Sadjadi A, Derakhshan MH, Shokuhi B, Fuladi R (2007) Survival rate of gastric and esophageal cancers in Ardabil province, North-West of Iran. Arch Iran Med 10(1):32–37PubMedGoogle Scholar
  24. 24.
    Salek R, Bezenjani SE, Saedi HS, Ashkiki MHH, Hosainzade SM, Mohtashami S, Aghai MA, Bahar MM, Ghavamnasiri MR (2009) A geographic area with better outcome of esophageal carcinoma: is there an effect of ethnicity and etiologic factors? Oncology 77(3–4):172–177CrossRefPubMedGoogle Scholar
  25. 25.
    Hubbard VS (2000) Defining overweight and obesity: what are the issues? Am J Clin Nutr 72(5):1067–1068PubMedGoogle Scholar
  26. 26.
    Ferronha I, Bastos A, Lunet N (2012) Prediagnosis lifestyle exposures and survival of patients with gastric cancer: systematic review and meta-analysis. Eur J Cancer Prev 21(5):449–452CrossRefPubMedGoogle Scholar
  27. 27.
    Walter V, Jansen L, Hoffmeister M, Brenner H (2014) Smoking and survival of colorectal cancer patients: systematic review and meta-analysis. Ann Oncol. doi:10.1093/annonc/mdu040 PubMedGoogle Scholar
  28. 28.
    Hong L, Zhang H, Zhao Q, Han Y, Yang J, Brain L (2013) Relation of excess body weight and survival in patients with esophageal adenocarcinoma: a meta-analysis. Dis Esophagus 26(6):623–627CrossRefPubMedGoogle Scholar
  29. 29.
    Parkin E, O’Reilly DA, Sherlock DJ, Manoharan P, Renehan AG (2014) Excess adiposity and survival in patients with colorectal cancer: a systematic review. Obes Rev 15(5):434–451CrossRefPubMedGoogle Scholar
  30. 30.
    Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2013) GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC CancerBase No. 11 [Internet]. International Agency for Research on Cancer. http://globocan.iarc.fr. Accessed 04 Sept 2014

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Centre for Research in MathematicsUniversity of Western SydneySydneyAustralia
  2. 2.School of Science and HealthUniversity of Western SydneySydneyAustralia
  3. 3.Faculty of MedicineUniversity of New South WalesSydneyAustralia
  4. 4.School of Computing, Engineering and MathematicsUniversity of Western SydneySydneyAustralia
  5. 5.QIMR Berghofer Medical Research InstituteBrisbaneAustralia

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