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Cancer Causes & Control

, Volume 26, Issue 7, pp 1027–1035 | Cite as

Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis

  • Annaka Schulte
  • Nirmala Pandeya
  • Jonathan Fawcett
  • Lin Fritschi
  • Harvey A. Risch
  • Penelope M. Webb
  • David C. Whiteman
  • Rachel E. Neale
Original paper

Abstract

Purpose

Gastric colonization with Helicobacter pylori (H. pylori) has been implicated in the pathogenesis of pancreatic cancer, but results of epidemiological studies have been inconclusive. We analyzed data from the Queensland Pancreatic Cancer Study, an Australian population-based case–control study, and incorporated our findings into an updated meta-analysis.

Methods

Blood samples were obtained from 580 patients and 626 controls, and enzyme-linked immunosorbent assay kits were used to determine seropositivity to H. pylori and its virulence protein, cytotoxin-associated gene A (CagA). Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using logistic regression. Results were incorporated into a meta-analysis along with results of studies identified through systematic literature review. Adjusted ORs and 95 % CIs were calculated using the DerSimonian and Laird random-effects model.

Results

No overall association was observed between H. pylori seropositivity and risk of pancreatic cancer (OR 1.00; 95 % CI 0.74–1.35). Nonsignificantly decreased pancreatic cancer risk was observed with CagA seropositivity (OR 0.74; 95 % CI 0.48–1.15) and increased risk with CagA-negative H. pylori seropositivity (OR 1.23; 95 % CI 0.83–1.82). Ten studies were included in the meta-analysis. There was no significant overall association between H. pylori seropositivity and pancreatic cancer risk (OR 1.13; 95 % CI 0.86–1.50), but evidence of CagA strain-specific associations (OR 0.78; 95 % CI 0.67–0.91 and OR 1.30; 95 % CI 1.02–1.65 for CagA-positive and CagA-negative strains, respectively).

Conclusions

Our results provide further evidence for the existence of strain-specific associations between H. pylori and pancreatic cancer.

Keywords

Pancreatic neoplasms Helicobacter pylori Epidemiology Risk factors 

Notes

Acknowledgments

We would like to acknowledge the support of the participants in this study. This study would not have been possible without the invaluable contribution of the research nurses, Fran Millar and Lisa Ferguson. The Queensland Pancreatic Cancer Study was funded by a National Health and Medical Research Council Australia (NHMRC) Project Grant. P Webb and L Fritschi are funded by NHMRC Senior Research Fellowships and N Pandeya by an NHMRC postdoctoral fellowship. D Whiteman is funded by an Australian Research Council Future fellowship.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standard

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of Population Health, Royal Brisbane HospitalQIMR Berghofer Medical Research InstituteBrisbaneAustralia
  2. 2.School of MedicineUniversity of QueenslandBrisbaneAustralia
  3. 3.School of Population HealthUniversity of QueenslandBrisbaneAustralia
  4. 4.School of Public HealthCurtin UniversityNedlandsAustralia
  5. 5.Yale School of Public HealthNew HavenUSA

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