Human papillomavirus vaccination is changing the epidemiology of high-grade cervical lesions in Australia
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In 2011, we reported the world’s first observation of a decline in high-grade cervical intra-epithelial neoplasia/adenocarcinoma in situ (CIN) in a population following the implementation of a national human papillomavirus (HPV) vaccination program . As measured using the population-based histopathology records held on the Victorian Cervical Cytology Registry, a dramatic decline was evident in very young women in Victoria, Australia, (aged <18 years) by the third year of Australia’s large-scale HPV vaccination program. Between 2007 and 2009, free vaccination was offered to women in the age range of 12–26 years using the quadrivalent HPV vaccine. One-quarter of Australia’s female population live in Victoria. Coverage achieved in the initial catch-up program was 83, 78, and 70 % for dose 1, 2, and 3 in 12- to 17-years-olds  and at least 55, 45, and 32 % in 18- to 26-year-old women (with some incomplete reporting of doses to the National HPV Vaccination Program...
KeywordsUnvaccinated Woman Level Registry Data Histopathology Record Recommend Screening Interval Victorian Cervical Cytology Registry
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