Advertisement

Cancer Causes & Control

, Volume 25, Issue 10, pp 1369–1377 | Cite as

ABO blood group and esophageal carcinoma risk: from a case–control study in Chinese population to meta-analysis

  • Wei Wang
  • Lei Liu
  • Zhiwei Wang
  • Xiaopeng Lu
  • Min Wei
  • Tianlong Lin
  • Yixin Zhang
  • Songqi Jiang
  • Qiang Wang
  • Ziang CaoEmail author
  • Minxin ShiEmail author
Original paper

Abstract

Purpose

The association between ABO blood group and the risk of esophageal carcinoma (EC) in previously published studies is uncertain and conflicting. The aim of the current study was to determine the correlation of ABO blood group with EC risk via a case–control study and meta-analysis.

Methods

We performed a population-based case–control study of 3,595 cases and 41,788 controls in Chinese population to evaluate the association between ABO blood group and EC risk. Then, a comprehensive meta-analysis combining our original data and previously published data was conducted to clearly discern the real relationship. The strength of association was measured by odds ratios (ORs) with 95 % confidence intervals (CI).

Results

In our case–control study, the risk of EC in blood group B was significantly higher than that in non-B groups (A, O, and AB) (OR = 1.15, 95 % CI 1.09–1.21). Compared with non-O groups (A, B, and AB), individuals with blood group O demonstrated a reduced risk of EC (OR = 0.90, 95 % CI 0.85–0.94). The meta-analysis also indicated that blood group B was associated with significantly higher EC risk (OR = 1.20, 95 % CI 1.10–1.31), and people with blood group O had a decreased EC risk (OR = 0.94, 95 % CI 0.90–0.99). Neither the case–control study nor the meta-analysis produced any significant association of blood group A or AB with EC risk.

Conclusion

Results from our case–control study and the followed meta-analysis confirmed that there was an increased risk of EC in blood group B individuals, whereas a decreased risk of EC was observed in blood group O individuals.

Keywords

Esophageal carcinoma ABO blood group Case–control study Meta-analysis 

Notes

Acknowledgments

We gratefully acknowledge the assistance of Songyao Jiang from Department of Surgery, Eastern Hospital, Tongji University, Shanghai, for his skillful technical assistance. This study was supported in part by grant funding of NSFC (Natural Science Foundation of China, 81101847), Doctoral Fund of Ministry of Education of China (20110073120089), project supported by the Shanghai Committee of Science and Technology, China (124119a4801), mandatory project from Nantong Science and Technology Commission (Grant no.: HS2011006).

Conflict of interest

The authors confirm that there are no conflict of interests.

Supplementary material

10552_2014_442_MOESM1_ESM.docx (16 kb)
Checklist of items to include when reporting a systematic review or meta-analysis (DOCX 16 kb)
10552_2014_442_MOESM2_ESM.doc (68 kb)
Supplementary material 2 (DOC 68 kb)

References

  1. 1.
    Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69–90PubMedCrossRefGoogle Scholar
  2. 2.
    Jemal A, Center MM, DeSantis C, Ward EM (2010) Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev 19:1893–1907PubMedCrossRefGoogle Scholar
  3. 3.
    Wang JB, Jiang Y, Liang H et al (2012) Attributable causes of cancer in China. Ann Oncol : official journal of the European Society for Medical Oncology/ESMO. 23:2983–2989CrossRefGoogle Scholar
  4. 4.
    Wu M, Zhang ZF, Kampman E et al (2011) Does family history of cancer modify the effects of lifestyle risk factors on esophageal cancer? A population-based case-control study in China. Int J Cancer 128:2147–2157PubMedCrossRefGoogle Scholar
  5. 5.
    Yamamoto F, Clausen H, White T, Marken J, Hakomori S (1990) Molecular genetic basis of the histo-blood group ABO system. Nature 345:229–233PubMedCrossRefGoogle Scholar
  6. 6.
    Yamamoto F (1990) Cloning the ABH genes. Transfusion 30:671–672PubMedCrossRefGoogle Scholar
  7. 7.
    Ben Q, Wang K, Yuan Y, Li Z (2011) Pancreatic cancer incidence and outcome in relation to ABO blood groups among Han Chinese patients: a case-control study. Int J Cancer 128:1179–1186PubMedCrossRefGoogle Scholar
  8. 8.
    Li Q, Yu CH, Yu JH et al (2012) ABO blood group and the risk of hepatocellular carcinoma: a case-control study in patients with chronic hepatitis B. PLoS One 7:e29928PubMedCentralPubMedCrossRefGoogle Scholar
  9. 9.
    Urun Y, Utkan G, Cangir AK et al (2013) Association of ABO blood group and risk of lung cancer in a multicenter study in Turkey. Asian Pac J Cancer Prev 14:2801–2803PubMedCrossRefGoogle Scholar
  10. 10.
    Poole EM, Gates MA, High BA et al (2012) ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium. Cancer Causes Control : CCC. 23:1805–1810PubMedCentralPubMedCrossRefGoogle Scholar
  11. 11.
    Sheng L, Sun X, Zhang L, Su D (2013) ABO blood group and nasopharyngeal carcinoma risk in a population of Southeast China. Int J Cancer 133:893–897PubMedCrossRefGoogle Scholar
  12. 12.
    Gong Y, Yang YS, Zhang XM et al (2012) ABO blood type, diabetes and risk of gastrointestinal cancer in northern China. World J Gastroenterol 18:563–569PubMedCentralPubMedCrossRefGoogle Scholar
  13. 13.
    Hoffmann R, Craik DJ, Bokonyi K, Varga I, Otvos L Jr (1999) High level of aspartic acid-bond isomerization during the synthesis of an N-linked tau glycopeptide. J Pept Sci : an official publication of the European Peptide Society. 5:442–456CrossRefGoogle Scholar
  14. 14.
    Sato E, Maruta K, Yonezawa S, Nakamura T (1984) Blood group H(O) antigen in normal, dysplastic and carcinomatous esophageal epithelium. Gann 75:223–229PubMedGoogle Scholar
  15. 15.
    Meany DL, Chan DW (2011) Aberrant glycosylation associated with enzymes as cancer biomarkers. Clin Proteomics 8:7PubMedCentralPubMedCrossRefGoogle Scholar
  16. 16.
    Iodice S, Maisonneuve P, Botteri E, Sandri MT, Lowenfels AB (2010) ABO blood group and cancer. Eur J Cancer 46:3345–3350PubMedCrossRefGoogle Scholar
  17. 17.
    Sauerland S, Seiler CM (2005) Role of systematic reviews and meta-analysis in evidence-based medicine. World J Surg 29:582–587PubMedCrossRefGoogle Scholar
  18. 18.
    Stroup DF, Berlin JA, Morton SC et al (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA, J Am Med Assoc 283:2008–2012CrossRefGoogle Scholar
  19. 19.
    Wells GA, Shea B, O’connell D et al (2000) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 20 March 2014
  20. 20.
    DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188PubMedCrossRefGoogle Scholar
  21. 21.
    Leucht S, Kissling W, Davis JM (2009) How to read and understand and use systematic reviews and meta-analyses. Acta Psychiatr Scand 119:443–450PubMedCrossRefGoogle Scholar
  22. 22.
    Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539–1558PubMedCrossRefGoogle Scholar
  23. 23.
    Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634PubMedCentralPubMedCrossRefGoogle Scholar
  24. 24.
    Aird I, Lee DR, Roberts JA (1960) ABO blood groups and cancer of oesophagus, cancer of pancreas, and pituitary adenoma. Br Med J 1:1163–1166PubMedCentralPubMedCrossRefGoogle Scholar
  25. 25.
    Beasley WH (1964) The ABO blood groups of carcinoma of the oesophagus and of benign prostatic hyperplasia. J Clin Pathol 17:42–44PubMedCentralPubMedCrossRefGoogle Scholar
  26. 26.
    Hartmann O, Stavem P (1964) ABO blood-groups and cancer. Lancet 1:1305–1306PubMedCrossRefGoogle Scholar
  27. 27.
    Macafee AL (1967) Blood groups and gastrointestinal cancer. A comparison of the ABO distribution by site of lesion. Ulster Med J 36:51–52PubMedCentralPubMedGoogle Scholar
  28. 28.
    Ray KA (1980) Blood groups and cancer in India. Curr Anthropol 21:794–795CrossRefGoogle Scholar
  29. 29.
    Su M, Lu SM, Tian DP et al (2001) Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China. World J Gastroenterol 7:657–661PubMedGoogle Scholar
  30. 30.
    Afrose S (2005) Association of ABO blood group with malignancies. J Bangladesh Coll Phys Surg 23:18–24Google Scholar
  31. 31.
    Guleria K, Singh PH, Kaur HS, Sambyal V (2005) ABO blood groups in gastrointestinal tract (GIT) and breast carcinoma patients. Anthropologist 7:189–192Google Scholar
  32. 32.
    Aminian A, Mirsharifi R, Alibakhshi A, Khorgami Z, Dashti H, Hasani MS (2010) Relationship between esophageal cancer and blood groups. World Appl Sci J 8:503–508Google Scholar
  33. 33.
    Wang Z, Liu L, Ji J et al (2012) ABO blood group system and gastric cancer: a case-control study and meta-analysis. Int J Mol Sci 13:13308–13321PubMedCentralPubMedCrossRefGoogle Scholar
  34. 34.
    Risch HA, Lu L, Wang J et al (2013) ABO blood group and risk of pancreatic cancer: a study in shanghai and meta-analysis. Am J Epidemiol 177:1326–1337PubMedCentralPubMedCrossRefGoogle Scholar
  35. 35.
    Larsen RD, Ernst LK, Nair RP, Lowe JB (1990) Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen. Proc Natl Acad Sci USA 87:6674–6678PubMedCentralPubMedCrossRefGoogle Scholar
  36. 36.
    Yazer MH (2005) What a difference 2 nucleotides make: a short review of ABO genetics. Transfus Med Rev 19:200–209PubMedCrossRefGoogle Scholar
  37. 37.
    Tauchi K, Kakudo K, Machimura T, Makuuchi H, Mitomi T (1991) Immunohistochemical studies of blood group-related antigens in human superficial esophageal carcinomas. Cancer 67:3042–3050PubMedCrossRefGoogle Scholar
  38. 38.
    Le Pendu J, Marionneau S, Cailleau-Thomas A, Rocher J, Le Moullac-Vaidye B, Clement M (2001) ABH and Lewis histo-blood group antigens in cancer. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 109:9–31PubMedCrossRefGoogle Scholar
  39. 39.
    Pare G, Chasman DI, Kellogg M et al (2008) Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women. PLoS Genet 4:e1000118PubMedCentralPubMedCrossRefGoogle Scholar
  40. 40.
    Paterson AD, Lopes-Virella MF, Waggott D et al (2009) Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. Arterioscler Thromb Vasc Biol 29:1958–1967PubMedCentralPubMedCrossRefGoogle Scholar
  41. 41.
    Barbalic M, Dupuis J, Dehghan A et al (2010) Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. Hum Mol Genet 19:1863–1872PubMedCentralPubMedCrossRefGoogle Scholar
  42. 42.
    Melzer D, Perry JR, Hernandez D et al (2008) A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet 4:e1000072PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Wei Wang
    • 1
  • Lei Liu
    • 1
  • Zhiwei Wang
    • 2
  • Xiaopeng Lu
    • 3
  • Min Wei
    • 4
  • Tianlong Lin
    • 2
  • Yixin Zhang
    • 1
  • Songqi Jiang
    • 1
  • Qiang Wang
    • 1
  • Ziang Cao
    • 2
    Email author
  • Minxin Shi
    • 1
    Email author
  1. 1.Department of SurgeryThe Affiliated Tumor Hospital of Nantong UniversityNantongChina
  2. 2.Department of SurgeryShanghai Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina
  3. 3.Department of Blood ManagementNantong Blood CenterNantongChina
  4. 4.Department of Breast, International Peace Maternity and Child Health HospitalShanghai Jiao Tong UniversityShanghaiChina

Personalised recommendations