Cancer Causes & Control

, Volume 25, Issue 10, pp 1369–1377 | Cite as

ABO blood group and esophageal carcinoma risk: from a case–control study in Chinese population to meta-analysis

  • Wei Wang
  • Lei Liu
  • Zhiwei Wang
  • Xiaopeng Lu
  • Min Wei
  • Tianlong Lin
  • Yixin Zhang
  • Songqi Jiang
  • Qiang Wang
  • Ziang CaoEmail author
  • Minxin ShiEmail author
Original paper



The association between ABO blood group and the risk of esophageal carcinoma (EC) in previously published studies is uncertain and conflicting. The aim of the current study was to determine the correlation of ABO blood group with EC risk via a case–control study and meta-analysis.


We performed a population-based case–control study of 3,595 cases and 41,788 controls in Chinese population to evaluate the association between ABO blood group and EC risk. Then, a comprehensive meta-analysis combining our original data and previously published data was conducted to clearly discern the real relationship. The strength of association was measured by odds ratios (ORs) with 95 % confidence intervals (CI).


In our case–control study, the risk of EC in blood group B was significantly higher than that in non-B groups (A, O, and AB) (OR = 1.15, 95 % CI 1.09–1.21). Compared with non-O groups (A, B, and AB), individuals with blood group O demonstrated a reduced risk of EC (OR = 0.90, 95 % CI 0.85–0.94). The meta-analysis also indicated that blood group B was associated with significantly higher EC risk (OR = 1.20, 95 % CI 1.10–1.31), and people with blood group O had a decreased EC risk (OR = 0.94, 95 % CI 0.90–0.99). Neither the case–control study nor the meta-analysis produced any significant association of blood group A or AB with EC risk.


Results from our case–control study and the followed meta-analysis confirmed that there was an increased risk of EC in blood group B individuals, whereas a decreased risk of EC was observed in blood group O individuals.


Esophageal carcinoma ABO blood group Case–control study Meta-analysis 



We gratefully acknowledge the assistance of Songyao Jiang from Department of Surgery, Eastern Hospital, Tongji University, Shanghai, for his skillful technical assistance. This study was supported in part by grant funding of NSFC (Natural Science Foundation of China, 81101847), Doctoral Fund of Ministry of Education of China (20110073120089), project supported by the Shanghai Committee of Science and Technology, China (124119a4801), mandatory project from Nantong Science and Technology Commission (Grant no.: HS2011006).

Conflict of interest

The authors confirm that there are no conflict of interests.

Supplementary material

10552_2014_442_MOESM1_ESM.docx (16 kb)
Checklist of items to include when reporting a systematic review or meta-analysis (DOCX 16 kb)
10552_2014_442_MOESM2_ESM.doc (68 kb)
Supplementary material 2 (DOC 68 kb)


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Wei Wang
    • 1
  • Lei Liu
    • 1
  • Zhiwei Wang
    • 2
  • Xiaopeng Lu
    • 3
  • Min Wei
    • 4
  • Tianlong Lin
    • 2
  • Yixin Zhang
    • 1
  • Songqi Jiang
    • 1
  • Qiang Wang
    • 1
  • Ziang Cao
    • 2
    Email author
  • Minxin Shi
    • 1
    Email author
  1. 1.Department of SurgeryThe Affiliated Tumor Hospital of Nantong UniversityNantongChina
  2. 2.Department of SurgeryShanghai Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina
  3. 3.Department of Blood ManagementNantong Blood CenterNantongChina
  4. 4.Department of Breast, International Peace Maternity and Child Health HospitalShanghai Jiao Tong UniversityShanghaiChina

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