Menstrual and reproductive characteristics and breast density in young women
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Breast density is strongly related to breast cancer risk, but determinants of breast density in young women remain largely unknown.
Associations of reproductive and menstrual characteristics with breast density measured by magnetic resonance imaging were evaluated in a cross-sectional study of 176 healthy women, 25–29 years old, using linear mixed effects models.
Parity was significantly inversely associated with breast density. In multivariable adjusted models that included non-reproductive variables, mean percent dense breast volume (%DBV) decreased from 20.5 % in nulliparous women to 16.0 % in parous women, while mean absolute dense breast volume (ADBV) decreased from 85.3 to 62.5 cm3. Breast density also was significantly inversely associated with the age women started using hormonal contraceptives, whereas it was significantly positively associated with duration of hormonal contraceptive use. In adjusted models, mean %DBV decreased from 21.7 % in women who started using hormones at 12–17 years of age to 14.7 % in those who started using hormones at 22–28 years of age, while mean ADBV decreased from 86.2 to 53.7 cm3. The age at which women started using hormonal contraceptives and duration of hormone use were inversely correlated, and mean %DBV increased from 15.8 % in women who used hormones for not more than 2.0 years to 22.0 % in women who used hormones for more than 8 years, while mean ADBV increased from 61.9 to 90.4 cm3 over this interval.
Breast density in young women is inversely associated with parity and the age women started using hormonal contraceptives but positively associated with duration of hormone use.
KeywordsBreast density Parity Breast feeding Hormonal contraceptives Menarche Menstrual cycle
- 3.Velie EM (2006) Lifetime reproductive and anthropometric risk factors for breast cancer in postmenopausal women. Breast Dis 26:1–19Google Scholar
- 12.Dorgan JF, Liu L, Barton BA et al (2011) Adolescent diet and metabolic syndrome in young women: results of the Dietary Intervention Study in Children (DISC) follow-up study. J Clin Endocrinol Metab 96:E1999–2008Google Scholar
- 15.Kuczmarski R, Ogden C, Guo S et al (2002) 2000 CDC growth charts for the United States: methods and development. National Center for Health Statistics. Vital Health Stat 11:1–190Google Scholar
- 21.National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Pressure in Adults (2001) Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 285:2486–2497CrossRefGoogle Scholar
- 23.Lokate M, Kallenberg M, Karssemeijer N, Van den Bosch M, Peeters P, Van Gils C (2010) Volumetric breast density from full-field digital mammograms and its association with breast cancer risk factors: a comparison with a threshold method. Cancer Epidemiol Biomarkers Prev 19:3096–3105PubMedCrossRefGoogle Scholar
- 26.Woolcott CG, Koga K, Conroy SM, et al (2012) Mammographic density, parity and age at first birth, and risk of breast cancer: an analysis of four case–control studies. Breast Cancer Res Treat 132:1163–1171Google Scholar