Cancer Causes & Control

, Volume 24, Issue 9, pp 1757–1761

Prenatal DES exposure in relation to breast size

  • Julie R. Palmer
  • Deborah A. Boggs
  • Elizabeth E. Hatch
  • Rebecca Troisi
  • Linda Titus-Ernstoff
  • William C. Strohsnitter
  • Ervin Adam
  • Robert N. Hoover
Brief report

Abstract

Purpose

Prenatal DES exposure has been associated with increased risk of breast cancer, but the mechanisms are unknown. Larger bra cup size has also been associated with increased breast cancer risk, although not consistently. We investigated the relation of prenatal DES exposure to mammary gland mass, as estimated by bra cup size.

Methods

In 2006, 3,222 DES-exposed and 1,463 unexposed women reported their bra cup size, band size (chest circumference), and weight at age 20. Prevalence ratios (PR) were calculated for DES exposure in relation to large bra cup size, with control for year of birth and study cohort. Primary analyses were carried out among women who reported a chest circumference of no more than 32 inches because their cup size would be less influenced by fat mass.

Results

Within this group, DES-exposed women had an estimated 45 % increased prevalence (95 % CI 0.97–2.18) of large cup size (C or greater) relative to unexposed women. The PR was further increased among women in this group who had a body mass index of < 21 at age 20: PR = 1.83 (95 % CI 1.11–3.00). The PR for high-dose DES exposure relative to no exposure was 1.67, 95 % CI 1.02–2.73, whereas there was no association of bra cup size with low-dose exposure.

Conclusions

These results provide support for the hypothesis that in utero DES exposure may result in greater mammary gland mass. Taken together with previous research on bra size and breast cancer risk, these findings suggest a mechanism for a possible association of in utero DES exposure with increased risk of breast cancer.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Julie R. Palmer
    • 1
    • 2
  • Deborah A. Boggs
    • 1
  • Elizabeth E. Hatch
    • 2
  • Rebecca Troisi
    • 3
  • Linda Titus-Ernstoff
    • 4
  • William C. Strohsnitter
    • 5
  • Ervin Adam
    • 6
  • Robert N. Hoover
    • 3
  1. 1.Slone Epidemiology Center at Boston UniversityBostonUSA
  2. 2.Department of EpidemiologyBoston University School of Public HealthBostonUSA
  3. 3.Division of Cancer Epidemiology and Genetics, National Cancer InstituteNational Institutes of HealthBethesdaUSA
  4. 4.Departments of Community and Family Medicine and PediatricsDartmouth Medical School and the Norris Cotton Cancer CenterLebanonUSA
  5. 5.Department of Obstetrics and GynecologyNew England Medical CenterBostonUSA
  6. 6.Department of Molecular Virology and MicrobiologyBaylor College of MedicineHoustonUSA

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