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Cancer Causes & Control

, Volume 24, Issue 6, pp 1175–1183 | Cite as

Intakes of heme iron and zinc and colorectal cancer incidence: a meta-analysis of prospective studies

  • Lei Qiao
  • Yong FengEmail author
Original paper

Abstract

Background

Epidemiologic findings concerning the associations between intakes of heme iron and zinc and colorectal cancer (CRC) incidence yielded conflicting results. We aimed to investigate the associations by performing a meta-analysis of prospective studies.

Methods

We conducted a literature search on PubMed and EMBASE databases up to December 2012 to identify the prospective studies that investigated the relationships between heme iron or zinc intake and risk of CRC. We also reviewed the bibliographies of the retrieved articles to identify additional studies. We used a random-effects model to calculate the summary relative risks (RRs) with 95 % confidence intervals (CIs).

Results

Eight studies on heme iron intake and six studies on zinc intake met the inclusion criteria. The summary RR of CRC for the highest versus the lowest intake was 1.14 (95 % CI = 1.04–1.24) for heme iron and 0.83 (95 % CI = 0.72–0.94) for zinc, respectively. The observed associations were not significantly modified by subsites within the colorectum, sex, geographic area, study duration, the number of cases, or the range of intakes. In the dose–response analyses, the summary RR of CRC was 1.11 (95 % CI = 1.03–1.18) for heme iron intake of 1 mg/day, and 0.86 (95 % CI = 0.78–0.96) for zinc intake of 5 mg/day, respectively. There was little evidence of publication bias.

Conclusion

This meta-analysis suggests a significant positive dose–response association of heme iron intake and a significant inverse dose–response association of zinc intake with risk of CRC.

Keywords

Heme iron Zinc Cohort studies Colorectal cancer Meta-analysis 

Notes

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of Colorectal Surgery and OncologyShengjing Hospital of China Medical UniversityShenyangChina

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