Cancer among patients with diabetes, obesity and abnormal blood lipids: a population-based register study in Sweden
- 715 Downloads
To study how the incidence of cancer is related to diabetes, obesity or abnormal blood lipids.
Diagnosis of diabetes, obesity or abnormal blood lipids was studied 0-10 years prior to the diagnosis of cancer in 19,756 cases of cancer and in 147,324 controls matched regarding age, sex and domicile.
Diabetes was significantly more common prior to diagnosis in patients with liver, pancreatic, colon and urinary tract/bladder cancer and in patients with breast cancer diagnosed with diabetes 0–4 years prior to the cancer diagnosis. A lower risk of diabetes was seen in patients with prostate carcinoma among individuals with diabetes diagnosed 5–10 years prior to the cancer diagnosis. The findings remained after adjusting for obesity and high blood lipids. Obesity was significantly more common in patients with endometrial, colon and kidney cancer and with breast cancer above the age of 60 years in those where obesity was diagnosed close to the diagnosis of cancer. High blood lipids were significantly more common in patients with ovarian cancer and less common in patients with breast cancer.
The study confirms some previous findings concerning comorbidity and cancer and highlights some new ones.
KeywordsCancer Diabetes Obesity Abnormal blood lipids Comorbidity Epidemiology Insulin and metformin therapy
Supported by grants from the Southern Regional Health Care Committee (Södra Regionvårdsnämnden), Swedish Cancer Society and Region Scania Funds. All authors have made substantial contributions to all of the following: (1) the conception and design of the study, or acquisition of data, or analysis and interpretation of data, (2) drafting the article or revising it critically for important intellectual content, (3) final approval of the version to be submitted.
Conflict of interest
The authors have no conflicts of interest.
- 1.LeRoith D, Novosyadlyy R, Gallagher EJ, Lann D, Vijayakumar A, Yakar S (2008) Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence. Exp Clin Endocrinol Diabetes 116(Suppl 1):S4–S6PubMedCrossRefGoogle Scholar
- 13.The National Board of Health and Welfare (2008) Cancer incidence in Sweden 2007. Health Dis 11:1–117Google Scholar
- 15.Li D, Tang H, Hassan MM, Holly EA, Bracci PM, Silverman DT (2010) Diabetes and risk of pancreatic cancer: a pooled analysis of three large case-control studies. Cancer Causes Control [Epub 2010/11/26]Google Scholar
- 31.Chu DI, Freedland SJ (2010) Metabolic risk factors in prostate cancer. Cancer [Epub 2010/12/01]Google Scholar