Cancer Causes & Control

, Volume 23, Issue 4, pp 565–574 | Cite as

Body fat distribution and breast cancer risk: findings from the Nigerian breast cancer study

  • Temidayo O. Ogundiran
  • Dezheng Huo
  • Adeniyi Adenipekun
  • Oladapo Campbell
  • Rasaaq Oyesegun
  • Effiong Akang
  • Clement Adebamowo
  • Olufunmilayo I. Olopade
Original paper

Abstract

Purpose

The relationship between overall obesity and breast cancer risk has been well recognized, but the role of central obesity in breast cancer development is uncertain.

Methods

Between 1998 and 2009, 1,233 invasive breast cancer cases and 1,101 community controls were recruited into the Nigerian Breast Cancer Study at Ibadan, Nigeria. Logistic regressions were used to calculate multivariate odds ratio (OR) and 95% confidence intervals (CI), adjusting for age, body mass index (BMI), and other known risk factors for breast cancer.

Results

The OR for the highest quartile group of waist circumference relative to the lowest was 2.39 (95% CI, 1.59–3.60; P-trend <0.001). Comparing women with waist/hip ratio (WHR) in the lowest quartile group, the OR for women in the highest quartile category was 2.15 (95% CI, 1.61–2.85; P-trend <0.001). An inverse association was observed between hip circumference and breast cancer, with an OR of 0.36 for the highest quartile (95% CI, 0.24–0.55; P-trend <0.001). The effects of these three measures existed in both pre- and postmenopausal women. Of note, we found a significant interaction between WHR and BMI (P-interaction = 0.016): the OR comparing the highest to the lowest WHR quartile was 2.81 (95% CI, 1.90–4.16) for women with BMI < 25 kg/m2 and 1.70 (95% CI, 1.11–2.61) for women with BMI ≥ 25 kg/m2.

Conclusions

These results suggest that central adiposity, measured by waist circumference and waist/hip ratio, was an important risk factor for breast cancer in Nigerian women, and the effect of central adiposity was strong in normal-weight women.

Keywords

Africa Breast neoplasms Body fat distribution Waist circumference Waist/hip ratio 

Notes

Acknowledgments

The study was funded by the National Cancer Institute at the National Institutes of Health (CA-RO1 89085-01A and P50 CA125183) and the Dr. Ralph and Marian Falk Medical Research Trust. The authors thank the interviewers, data managers, and support staff at the University College Hospital Ibadan and the data managers at the University of Chicago for their diligent and professional work.

Conflict of interest

None declared.

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Temidayo O. Ogundiran
    • 1
  • Dezheng Huo
    • 2
  • Adeniyi Adenipekun
    • 3
  • Oladapo Campbell
    • 3
  • Rasaaq Oyesegun
    • 3
  • Effiong Akang
    • 4
  • Clement Adebamowo
    • 5
  • Olufunmilayo I. Olopade
    • 6
  1. 1.Department of Surgery College of MedicineUniversity of IbadanIbadanNigeria
  2. 2.Department of Health StudiesUniversity of ChicagoChicagoUSA
  3. 3.Department of Radiotherapy College of MedicineUniversity of IbadanIbadanNigeria
  4. 4.Department of Pathology, College of MedicineUniversity of IbadanIbadanNigeria
  5. 5.Department of Epidemiology and Preventive MedicineUniversity of MarylandCollege ParkUSA
  6. 6.Center for Clinical Cancer Genetics and Global Health, Department of Medicine, Hematology/OncologyUniversity of ChicagoChicagoUSA

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