Cancer Causes & Control

, Volume 24, Issue 1, pp 181–191

Effects of an exercise and hypocaloric healthy eating program on biomarkers associated with long-term prognosis after early-stage breast cancer: a randomized controlled trial

  • E. Scott
  • A. J. Daley
  • H. Doll
  • N. Woodroofe
  • R. E. Coleman
  • N. Mutrie
  • H. Crank
  • H. J. Powers
  • J. M. Saxton
Original paper

DOI: 10.1007/s10552-012-0104-x

Cite this article as:
Scott, E., Daley, A.J., Doll, H. et al. Cancer Causes Control (2013) 24: 181. doi:10.1007/s10552-012-0104-x

Abstract

Excess body weight at diagnosis and weight gain after breast cancer are associated with poorer long-term prognosis. This study investigated the effects of a lifestyle intervention on body weight and other health outcomes influencing long-term prognosis in overweight women (BMI > 25.0 kg/m2) recovering from early-stage (stage I–III) breast cancer. A total of 90 women treated 3–18 months previously were randomly allocated to a 6-month exercise and hypocaloric healthy eating program (n = 47, aged 55.6 ± 10.2 year) or control group (n = 43, aged 55.9 ± 8.9 year). Women in the intervention group received three supervised exercise sessions per week and individualized dietary advice, supplemented by weekly nutrition seminars. Body weight, waist circumference, waist/hip ratio [WHR], cardiorespiratory fitness, blood biomarkers associated with breast cancer recurrence and cardiovascular disease risk, and quality of life (FACT-B) were assessed at baseline and 6 months. Three-day diet diaries were used to assess macronutrient and energy intakes. A moderate reduction in body weight in the intervention group (median difference from baseline of −1.09 kg; IQR −0.15 to −2.90 kg; p = 0.07) was accompanied by significant reductions in waist circumference (p < 0.001), WHR (p = 0.005), total (p = 0.021) and saturated fat (p = 0.006) intakes, leptin (p = 0.005), total cholesterol (p = 0.046), and resting diastolic blood pressure (p = 0.03). Cardiopulmonary fitness (p < 0.001) and FACT-B quality of life (p = 0.004) also showed significant improvements in the intervention group. These findings suggest that an individualized exercise and a hypocaloric healthy eating program can positively impact upon health outcomes influencing long-term prognosis in overweight women recovering from early-stage breast cancer.

Keywords

Breast cancer Lifestyle intervention Health outcomes 

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • E. Scott
    • 1
  • A. J. Daley
    • 2
  • H. Doll
    • 3
  • N. Woodroofe
    • 4
  • R. E. Coleman
    • 5
  • N. Mutrie
    • 6
  • H. Crank
    • 7
  • H. J. Powers
    • 8
  • J. M. Saxton
    • 9
  1. 1.School of Health and Related ResearchUniversity of SheffieldSheffieldUK
  2. 2.Department of Primary Care Clinical SciencesUniversity of BirminghamBirminghamUK
  3. 3.School of Medicine, Health Policy and PracticeUniversity of East AngliaNorwichUK
  4. 4.Biomedical Research CentreSheffield Hallam UniversitySheffieldUK
  5. 5.CR-UK/YCR Sheffield Cancer Research Centre, Weston Park HospitalUniversity of SheffieldSheffieldUK
  6. 6.Institute for Sport, Physical Education and Health SciencesUniversity of EdinburghEdinburghUK
  7. 7.Centre for Sport and Exercise ScienceSheffield Hallam UniversitySheffieldUK
  8. 8.Human Nutrition Unit, Department of OncologyUniversity of SheffieldSheffieldUK
  9. 9.Faculty of Medicine and Health Sciences, School of Allied Health ProfessionsUniversity of East AngliaNorwichUK

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