Cancer Causes & Control

, Volume 24, Issue 1, pp 61–69

Comorbidities and endometrial cancer survival in Hispanics and non-Hispanic whites

  • Linda S. Cook
  • Harold E. Nelson
  • Myles Cockburn
  • Sara H. Olson
  • Carolyn Y. Muller
  • Charles L. Wiggins
Original paper

DOI: 10.1007/s10552-012-0090-z

Cite this article as:
Cook, L.S., Nelson, H.E., Cockburn, M. et al. Cancer Causes Control (2013) 24: 61. doi:10.1007/s10552-012-0090-z



We investigated comorbidities and endometrial cancer survival by ethnicity because Hispanic whites (HWs) have worse survival than non-Hispanic whites (NHWs).


An endometrial cancer cohort (1992–2004) established with the Surveillance, Epidemiology and End Results-Medicare-linked database (n = 3,286) was followed through 2007. Endometrial cancer-specific and other cause mortality were evaluated with multivariate hazard ratios (mHRs).


HWs were more likely than NHWs to have regional/distant disease (31.7 vs. 24.8 %), diabetes (31.7 vs. 11.0 %), and hypertension (49.4 vs. 37.6 %). HWs had poorer endometrial cancer-specific survival than NHWs (age-adjusted HR = 1.28; 95% CI 1.01–1.61), but not after adjustment for tumor characteristics and treatment (mHR = 1.02; 95% CI 0.81–1.29). In contrast, even after adjustment for cancer-related factors, other cause mortality in HWs was elevated (mHR = 1.27; 95% CI 1.01–1.59), but not after further adjustment for comorbid conditions (mHR = 1.07; 95% CI 0.85–1.35).


Comorbidities, particularly diabetes, were more common in HWs than in NHWs and impacted other cause mortality. Improving diabetes management may be an effective means of improving other cause mortality. This may be particularly true for HWs, given their particularly high prevalence of diabetes.


Endometrial neoplasms Comorbidities Survival SEER Medicare 

Supplementary material

10552_2012_90_MOESM1_ESM.doc (77 kb)
Supplementary material 1 (DOC 77 kb)

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Linda S. Cook
    • 1
  • Harold E. Nelson
    • 2
  • Myles Cockburn
    • 3
  • Sara H. Olson
    • 4
  • Carolyn Y. Muller
    • 5
  • Charles L. Wiggins
    • 1
  1. 1.Division of Epidemiology and Biostatistics, Department of Internal Medicine and UNM Cancer Research and Treatment Center, MSC 10 55501 University of New MexicoAlbuquerqueUSA
  2. 2.New Mexico Tumor RegistryUniversity of New MexicoAlbuquerqueUSA
  3. 3.Department of Preventive Medicine and USC/Norris Comprehensive Cancer CenterUniversity of Southern CaliforniaLos AngelesUSA
  4. 4.Epidemiology and BiostatisticsMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  5. 5.Division of Gynecologic Oncology, Department of Obstetrics and GynecologyUniversity of New MexicoAlbuquerqueUSA

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