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Cancer Causes & Control

, Volume 23, Issue 12, pp 1995–2002 | Cite as

Tobacco consumption and genetic susceptibility to nasopharyngeal carcinoma (NPC) in Thailand

  • Jajah Fachiroh
  • Suleeporn Sangrajrang
  • Mattias Johansson
  • Hélène Renard
  • Valérie Gaborieau
  • Amélie Chabrier
  • Somjin Chindavijak
  • Paul Brennan
  • James D. McKayEmail author
Original paper

Abstract

Background

The incidence of nasopharyngeal carcinoma (NPC) varies substantially worldwide, with an endemic pocket in Southeast Asia.

Method

We assessed lifestyle and genetic factors in relation to NPC risk among 681 NPC cases and 1,078 controls from Thailand. Evaluated lifestyle factors included traditionally preserved foods, tobacco smoking, betel quid chewing, and alcohol consumption. Genetic factors included six variants implicated in a previous a genome-wide association study (GWAS) of NPC and three variants residing near the CHRNA3 and TERT genes that were linked to lung cancer risk in Asian populations. Odds ratios (OR) and 95 % confidence intervals (95 % CI) were estimated using unconditional logistic regression.

Results

Frequent consumption of fermented vegetables was associated with increased NPC risk (OR of consumption ≥weekly vs. ≤rare 1.78, 95 % CI 1.24–2.55, p trend = 0.005), as was tobacco smoking (p trend < 0.001), former and current smokers displaying OR of 1.57 (95 % CI 1.10–2.30) and 2.00 (95 % CI 1.48–2.71) compared to never smokers, respectively. Four out of six genetic variants implicated in the recent NPC GWAS were associated with NPC risk (p trend ≤ 0.03), as well as two variants (rs402710 and rs2736098) on the TERT locus at 5p15.33 (p = 0.004 and p = 0.04, respectively).

Conclusions

These results strengthen our previous observation that tobacco smoking is an important risk factor of NPC in this population. Four out of six genetic variants identified in a recent NPC GWAS were confirmed, and the association noted with variants on 5p15.33 suggests that this locus is involved in NPC susceptibility, representing a novel finding in NPC epidemiology.

Keywords

Nasopharyngeal carcinoma (NPC) Thailand Tobacco smoking Genetic Genotyping 

Notes

Acknowledgments

We are grateful to all subjects who participate in this study and field staffs for all the effort to collect the information. We would also like to thank Kevin Urayama for critically reading the manuscript and giving constructive suggestions. The work reported in this paper was undertaken during the tenure of a Postdoctoral Fellowship from the International Agency for Research on Cancer (IARC) (for Jajah Fachiroh).

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Jajah Fachiroh
    • 1
    • 3
  • Suleeporn Sangrajrang
    • 2
  • Mattias Johansson
    • 3
  • Hélène Renard
    • 3
  • Valérie Gaborieau
    • 3
  • Amélie Chabrier
    • 4
  • Somjin Chindavijak
    • 2
  • Paul Brennan
    • 3
  • James D. McKay
    • 4
    Email author
  1. 1.Department of Histology and Cell Biology, Faculty of MedicineGadjah Mada UniversityYogyakartaIndonesia
  2. 2.National Cancer InstituteBangkokThailand
  3. 3.Genetic Epidemiology GroupInternational Agency for Research on Cancer (IARC)Lyon cedex 08France
  4. 4.Genetic Cancer Susceptibility GroupInternational Agency for Research on Cancer (IARC)Lyon cedex 08France

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