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Cancer Causes & Control

, Volume 23, Issue 12, pp 1985–1994 | Cite as

Sun exposure and risk of epithelial ovarian cancer

  • Clara BodelonEmail author
  • Kara L. Cushing-Haugen
  • Kristine G. Wicklund
  • Jennifer A. Doherty
  • Mary Anne Rossing
Original paper

Abstract

Purpose

Associations between sun exposure (a primary source of vitamin D) and risk of ovarian cancer have been inconsistent. Furthermore, studies have not investigated whether sun exposure at different periods in the lifetime of a person results in differences in risk associations, and little is known about differences according to histological subtype.

Methods

Using a population-based case–control study of 1,334 non-Hispanic white women diagnosed with epithelial ovarian cancer in western Washington State between 2002 and 2009 and 1,679 non-Hispanic white controls, we assessed the relation of epithelial ovarian cancer with constitutional pigmentation characteristics, sun exposure behaviors, and an index of ultraviolet (UV) exposure based on residential history. Information was collected through in-person interviews. Logistic regression was used to compute odds ratios, 95 % confidence intervals, and trend p values (Ptrend).

Results

We noted no association with residence-based measures of UV exposure or self-reported sun exposure, either over the lifetime or within specific age intervals. Also, we observed little evidence of association between constitutional pigmentation characteristics and risk, save for a suggestion of increased risk among women who reported increased ability to suntan upon prolonged sun exposure (Ptrend = 0.03).

Conclusions

Results from this study suggest that sun exposure has little influence on the risk of epithelial ovarian cancer. Additional studies in populations with a wider gradient of sun exposure may yet be warranted.

Keywords

Ovarian cancer Sun exposure Histology Epidemiology 

Notes

Acknowledgments

The study was supported by grants R01 CA112523 and R01 CA87538 from the National Cancer Institute. CB was partially supported by grant number T32 CA009168 from the National Institutes of Health.

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Clara Bodelon
    • 1
    • 2
    • 3
    Email author
  • Kara L. Cushing-Haugen
    • 1
  • Kristine G. Wicklund
    • 1
  • Jennifer A. Doherty
    • 1
    • 4
  • Mary Anne Rossing
    • 1
    • 2
  1. 1.Division of Public Health SciencesFred Hutchinson Cancer Research CenterSeattleUSA
  2. 2.Department of Epidemiology, School of Public HealthUniversity of WashingtonSeattleUSA
  3. 3.Division of Cancer Epidemiology and GeneticsNational Cancer InstituteRockvilleUSA
  4. 4.Section of Biostatistics and EpidemiologyThe Geisel School of Medicine at DartmouthHanoverUSA

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