Cancer Causes & Control

, Volume 23, Issue 11, pp 1805–1810 | Cite as

ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium

  • Elizabeth M. Poole
  • Margaret A. Gates
  • Brigit A. High
  • Stephen J. Chanock
  • Daniel W. Cramer
  • Julie M. Cunningham
  • Brooke L. Fridley
  • Simon A. Gayther
  • Ellen L. Goode
  • Edwin S. Iversen
  • Jolanta Lissowska
  • Rachel T. Palmieri Weber
  • Paul D. P. Pharoah
  • Catherine M. Phelan
  • Susan J. Ramus
  • Joellen M. Schildkraut
  • Rebecca Sutphen
  • Ya-Yu Tsai
  • Jonathan Tyrer
  • Robert A. Vierkant
  • Nicolas Wentzensen
  • Hannah P. Yang
  • Kathryn L. Terry
  • Shelley S. Tworoger
Original paper

Abstract

Purpose

Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results.

Methods

In eight studies participating in the Ovarian Cancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis.

Results

Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95 % CI: 1.01–1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO: OR: 1.11; 95 % CI: 1.01–1.22; p = 0.03; AA: OR: 1.03; 95 % CI: 0.87–1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes.

Conclusion

Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.

Keywords

Ovarian cancer ABO blood group Ovarian Cancer Association Consortium (OCAC) Genetic epidemiology 

Supplementary material

10552_2012_59_MOESM1_ESM.doc (90 kb)
Supplementary material 1 (DOC 91 kb)

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Elizabeth M. Poole
    • 1
    • 2
  • Margaret A. Gates
    • 1
    • 2
    • 14
  • Brigit A. High
    • 1
    • 15
  • Stephen J. Chanock
    • 3
  • Daniel W. Cramer
    • 4
  • Julie M. Cunningham
    • 5
  • Brooke L. Fridley
    • 5
  • Simon A. Gayther
    • 6
  • Ellen L. Goode
    • 5
  • Edwin S. Iversen
    • 7
  • Jolanta Lissowska
    • 8
  • Rachel T. Palmieri Weber
    • 9
  • Paul D. P. Pharoah
    • 10
  • Catherine M. Phelan
    • 11
  • Susan J. Ramus
    • 6
  • Joellen M. Schildkraut
    • 9
    • 12
  • Rebecca Sutphen
    • 13
  • Ya-Yu Tsai
    • 11
  • Jonathan Tyrer
    • 10
  • Robert A. Vierkant
    • 5
  • Nicolas Wentzensen
    • 3
  • Hannah P. Yang
    • 3
  • Kathryn L. Terry
    • 4
  • Shelley S. Tworoger
    • 1
    • 2
  1. 1.Channing Laboratory, Department of Medicine, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA
  2. 2.Department of EpidemiologyHarvard School of Public HealthBostonUSA
  3. 3.Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesdaUSA
  4. 4.Obstetrics and Gynecology Epidemiology Center, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA
  5. 5.Mayo Clinic College of MedicineRochesterUSA
  6. 6.Department of Preventive Medicine, Keck School of MedicineUniversity of Southern CaliforniaLos AngelesUSA
  7. 7.Department of Statistical ScienceDuke UniversityDurhamUSA
  8. 8.Maria Sklodowska-Curie Memorial Cancer Center and Institute of OncologyWarsawPoland
  9. 9.Department of Community and Family MedicineDuke University Medical CenterDurhamUSA
  10. 10.University of CambridgeCambridgeUK
  11. 11.H. Lee Moffitt Cancer Center and Research InstituteTampaUSA
  12. 12.Cancer Prevention, Detection and Control Research ProgramDuke Cancer InstituteDurhamUSA
  13. 13.Universty of South Florida College of MedicineTampaUSA
  14. 14.New England Research InstitutesWatertownUSA
  15. 15.Amherst CollegeAmherstUSA

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