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Cancer Causes & Control

, Volume 23, Issue 9, pp 1429–1442 | Cite as

Effects of phenotypes in heterocyclic aromatic amine (HCA) metabolism–related genes on the association of HCA intake with the risk of colorectal adenomas

  • Aline Barbir
  • Jakob Linseisen
  • Silke Hermann
  • Rudolf Kaaks
  • Birgit Teucher
  • Monika Eichholzer
  • Sabine Rohrmann
Original paper

Abstract

Background

Heterocyclic aromatic amines (HCA), formed by high-temperature cooking of meat, are well-known risk factors for colorectal cancer (CRC). Enzymes metabolizing HCAs may influence the risk of CRC depending on the enzyme activity level. We aimed to assess effect modification by polymorphisms in the HCA-metabolizing genes on the association of HCA intake with colorectal adenoma (CRA) risk, which are precursors of CRC.

Methods

A case–control study nested in the EPIC-Heidelberg cohort was conducted. Between 1994 and 2005, 413 adenoma cases were identified and 796 controls were matched to cases. Genotypes were determined and used to predict phenotypes (i.e., enzyme activities). Odds ratios (OR) and corresponding 95 % confidence intervals (CI) were calculated by logistic regression analysis.

Results

CRA risk was positively associated with PhIP, MeIQx, and DiMeIQx (p trend = 0.006, 0.022, and 0.045, respectively) intake. SULT1A1 phenotypes modified the effect of MeIQx on CRA risk (p Interaction > 0.01) such that the association of MeIQx intake with CRA was stronger for slow than for normal phenotypes. Other modifying effects by phenotypes did not reach statistical significance.

Conclusions

HCA intake is positively associated with CRA risk, regardless of phenotypes involved in the metabolizing process. Due to the number of comparisons made in the analysis, the modifying effect of SULT1A1 on the association of HCA intake with CRA risk may be due to chance.

Keywords

Colorectal adenoma Genetic polymorphisms Phenotypes Heterocyclic aromatic amines 

Notes

Acknowledgments

This study was granted by the Kurt-Eberhard-Bode Foundation.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Aline Barbir
    • 1
  • Jakob Linseisen
    • 2
    • 3
  • Silke Hermann
    • 3
  • Rudolf Kaaks
    • 3
  • Birgit Teucher
    • 3
  • Monika Eichholzer
    • 1
  • Sabine Rohrmann
    • 1
    • 3
  1. 1.Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive MedicineUniversity of ZurichZürichSwitzerland
  2. 2.Institute of Epidemiology IHelmholtz Zentrum MünchenNeuherbergGermany
  3. 3.German Cancer Research Center (DKFZ)HeidelbergGermany

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