Cancer Causes & Control

, 22:1587

Associations of pregnancy characteristics with maternal and cord steroid hormones, angiogenic factors, and insulin-like growth factor axis

  • Jessica M. Faupel-Badger
  • Yuping Wang
  • S. Ananth Karumanchi
  • Frank Stanczyk
  • Michael Pollak
  • Thomas McElrath
  • Robert N. Hoover
  • Rebecca Troisi
Original paper

Abstract

Background

The objective of this study was to comprehensively profile biological factors in pregnancy that have been postulated to be important components of the in utero environment and may also have relevance to later susceptibility to cancer and other chronic diseases.

Methods

Steroid sex hormones, IGFs, and angiogenic factors were measured in maternal and cord serum from term normotensive pregnancies. Spearman correlations and linear regression estimated relationships among the biological factors and clinical characteristics.

Results

The analytes were generally not correlated between maternal and fetal circulations. However, significant correlations were demonstrated among several analytes within maternal or cord samples. A few analytes were associated with clinical characteristics (e.g., maternal IGF-1 and IGFBP-3 were inversely correlated with offspring birth weight, while maternal leptin and cord testosterone were positively correlated with this characteristic). Maternal androgens were higher in African-Americans than whites, and maternal PlGF and soluble fms-like tyrosine kinase-1 (sFlt-1) were higher in male than female offspring.

Conclusions

There were significant correlations among analytes, but the patterns differed depending on whether they were measured in the maternal or fetal circulation. The number and magnitude of correlations among analytes, however, should affect the design and interpretation of future studies.

Keywords

African-American Angiogenic factors IGF Leptin Prolactin 

Copyright information

© Springer Science+Business Media B.V. (outside the USA)  2011

Authors and Affiliations

  • Jessica M. Faupel-Badger
    • 1
    • 2
  • Yuping Wang
    • 3
  • S. Ananth Karumanchi
    • 4
  • Frank Stanczyk
    • 5
  • Michael Pollak
    • 6
  • Thomas McElrath
    • 7
  • Robert N. Hoover
    • 2
  • Rebecca Troisi
    • 2
  1. 1.Cancer Prevention Fellowship Program, Center for Cancer TrainingNational Cancer InstituteBethesdaUSA
  2. 2.Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesdaUSA
  3. 3.Department of Obstetrics and GynecologyLouisiana State University Health Sciences CenterShreveportUSA
  4. 4.Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA
  5. 5.Departments of Obstetrics and Gynecology, and Preventive MedicineUniversity of Southern California Keck School of MedicineLos AngelesUSA
  6. 6.Department of MedicineMcGill UniversityMontrealCanada
  7. 7.Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA

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