Cancer Causes & Control

, 22:1383

Retinol, vitamins A, C, and E and breast cancer risk: a meta-analysis and meta-regression

  • Hu Fulan
  • Jiang Changxing
  • Wang Yi Baina
  • Zhang Wencui
  • Lin Chunqing
  • Wang Fan
  • Li Dandan
  • Sun Dianjun
  • Wang Tong
  • Pang Da
  • Zhao Yashuang
Original paper

Abstract

Objective

To comprehensively summarize the associations between retinol, vitamins A, C, and E and breast cancer, and quantitatively estimate their dose–response relationships.

Methods

We searched PubMed, Embase, and Cochrane databases (from January 1982 to 15 March 2011) and the references of the relevant articles in English with sufficient information to estimate relative risk or odds ratio and the 95% confidence intervals, and comparable categories of vitamins. Two reviewers independently extracted data using a standardized form, with any discrepancy adjudicated by the third reviewer.

Results

Overall, 51 studies met the inclusion criteria. Comparing the highest with the lowest intake, total vitamin A intake reduced the breast cancer risk by 17% (pooled OR = 0.83, 95% CI: 0.78–0.88). Further subgroup analysis based on study design did not change the significant reduction. Although the dietary vitamin A, dietary vitamin E, and total vitamin E intake all reduced breast cancer risk significantly when data from all studies were pooled, the results became nonsignificant when data from cohort studies were pooled. The significant association between total retinol intake and breast cancer in all studies became nonsignificant in case–control studies but remain significant in cohort studies. No significant dose–response relationship was observed in the higher intake of these vitamins with reduced breast cancer risk.

Conclusions

Our results indicate that both the total intake of vitamin A and retinol could reduce breast cancer risk. However, associations between other vitamins and breast cancer seem to be limited.

Keywords

Retinol Vitamin A Vitamin C Vitamin E Breast cancer Meta-analysis 

Supplementary material

10552_2011_9811_MOESM1_ESM.doc (1.2 mb)
Supplementary material 1 (DOC 1.17 MB)

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Hu Fulan
    • 1
  • Jiang Changxing
    • 2
  • Wang Yi Baina
    • 1
  • Zhang Wencui
    • 1
  • Lin Chunqing
    • 1
  • Wang Fan
    • 1
  • Li Dandan
    • 1
  • Sun Dianjun
    • 2
  • Wang Tong
    • 2
  • Pang Da
    • 3
  • Zhao Yashuang
    • 1
  1. 1.Department of Epidemiology, Public Health CollegeHarbin Medical UniversityNangang District, HarbinPeople’s Republic of China
  2. 2.Center for Endemic Disease ControlHarbin Medical UniversityHarbinPeople’s Republic of China
  3. 3.Department of Breast SurgeryThird Affiliated Clinical Hospital of Harbin Medical UniversityNangang District, HarbinPeople’s Republic of China

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