Cancer Causes & Control

, 22:1375 | Cite as

Dietary calcium and magnesium intake in relation to cancer incidence and mortality in a German prospective cohort (EPIC-Heidelberg)

  • Kuanrong Li
  • Rudolf Kaaks
  • Jakob Linseisen
  • Sabine Rohrmann
Original paper

Abstract

To prospectively evaluate the associations of dietary calcium and magnesium intake with cancer incidence and mortality, data of 24,323 participants of the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg), who were aged 35–64 years and cancer-free at recruitment (1994–1998), were analyzed using multivariate Cox regression models. After an average follow-up time of 11 years, 2,050 incident cancers were diagnosed and 513 cancer deaths occurred. Dietary calcium intake was inversely but not statistically significantly associated with colorectal cancer risk (hazard ratio [HR] for per 100 mg increase in intake: 0.95; 95% confidence interval [CI]: 0.88, 1.02) and lung cancer risk (HR for per 100 mg increase in intake: 0.94; 95% CI: 0.87, 1.02). No statistically significant associations were observed between dietary calcium intake and site-specific or overall cancer incidence or mortality. Dietary magnesium intake was not statistically significantly associated with any of the investigated outcomes. This prospective cohort study provides no strong evidence to support that high dietary calcium and magnesium intake in the intake range observed in a German population may reduce cancer incidence or mortality.

Keywords

Calcium Magnesium Diet Cancer Incidence Mortality 

Notes

Acknowledgments

This study was funded by the Deutsche Krebshilfe [Grant-No.: 70-488-Ha I] and the Graduiertenkolleg 793: Epidemiology of communicable and chronic non-communicable diseases and their interrelationships.

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Kuanrong Li
    • 1
  • Rudolf Kaaks
    • 1
  • Jakob Linseisen
    • 1
    • 2
  • Sabine Rohrmann
    • 1
    • 3
  1. 1.Division of Cancer EpidemiologyGerman Cancer Research CentreHeidelbergGermany
  2. 2.Institute of Epidemiology IHelmholtz Centre MunichNeuherbergGermany
  3. 3.Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive MedicineUniversity of ZurichZurichSwitzerland

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