Intake of whole-grain products and risk of prostate cancer among men in the Danish Diet, Cancer and Health cohort study
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High intake of whole-grain products may protect against prostate cancer, but overall evidence is limited and inconclusive. The aim of the present study was to investigate the relationship between the intake of whole-grain products and risk of prostate cancer in a large prospective cohort.
A total of 26,691 men aged 50–64 years participated in the Diet, Cancer and Health cohort study and provided information about diet and potential prostate cancer risk factors. During a median follow-up of 12.4 years, we identified 1,081 prostate cancer cases. Associations between whole-grain product intake and prostate cancer incidence were analyzed using Cox’s regression model.
Overall, there was no association between total intake of whole-grain products and prostate cancer risk (adjusted incidence rate ratio per 50 g day−1: 1.00 (95% confidence interval: 0.96, 1.05)) as well as between intake of the specific whole-grain products: whole-grain rye bread, whole-grain bread, and oatmeal, and risk of prostate cancer. No risk estimates did differ according to either stage or grade of disease.
Results from this prospective study suggest that higher intakes of total or specific whole-grain products are not associated with risk of prostate cancer in a population of Danish middle-aged men.
KeywordsWhole-grain products Prostate cancer Prospective study
We thank Katja Boll (data manager), Connie Stripp (dietician), and Jytte Fogh Larsen (project coordinator) for assistance with the data collection and handling. This study was supported by a grant from the Danish Council for Strategic Research, Programme Commission on Food and Health for the project “Breaking down barriers for healthier eating by consumer-led product development.”
Conflict of interest
The authors declare no conflicts of interest.
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