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Cancer Causes & Control

, Volume 22, Issue 7, pp 1021–1035 | Cite as

Adiposity and the risk of colorectal adenomatous polyps: a meta-analysis

  • Yeon Ji Lee
  • Seung-Kwon Myung
  • BeLong Cho
  • Byung-Joo Park
  • Jin Ho Park
  • Woong Ju
  • Min-Sun Park
  • Ji-Ho Choi
Original paper

Abstract

Objective

The findings from epidemiological studies addressing the association between adiposity and the risk of colorectal adenomatous polyps are inconsistent. We performed a meta-analysis of epidemiological studies including cross-sectional, case–control, and cohort studies.

Methods

We searched PubMed and EMBASE in June, 2010. All searched articles were reviewed and selected independently by two evaluators according to pre-determined selection criteria.

Results

We included 25 studies (nine cross-sectional studies, eleven case–control studies, and five prospective cohort studies) that comprised a total of 300,671 participants and 20,903 cases in the final analysis. When all studies were pooled, the odds ratio (OR) or relative risk (RR) of adiposity and abdominal adiposity for colorectal adenomatous polyp risk was 1.43 (95% confidence interval (CI) 1.23–1.67; n = 22) and 1.42 (95% CI 1.30–1.56; n = 12), respectively. Similarly, an increased risk of colorectal adenomatous polyps was observed in most of the subgroup meta-analyses.

Conclusions

Overall, we found that adiposity and abdominal adiposity significantly increased the risk of colorectal adenomatous polyps in a meta-analysis of epidemiological studies.

Keywords

Adiposity Abdominal adiposity Colorectal adenomatous polyps Meta-analysis 

Notes

Acknowledgment

This work was supported by INHA University Research Grant.

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Yeon Ji Lee
    • 1
  • Seung-Kwon Myung
    • 2
  • BeLong Cho
    • 3
  • Byung-Joo Park
    • 4
  • Jin Ho Park
    • 3
  • Woong Ju
    • 5
  • Min-Sun Park
    • 3
  • Ji-Ho Choi
    • 1
  1. 1.Department of Family Medicine, School of MedicineInha UniversityIncheonRepublic of Korea
  2. 2.Cancer Epidemiology Branch, Research Institute, Smoking Cessation Clinic, Family Medicine Clinic, and Center for Cancer Prevention and Detection, Hospital, National Cancer CenterGoyangRepublic of Korea
  3. 3.Health Promotion Center, Department of Family MedicineSeoul National University HospitalSeoulRepublic of Korea
  4. 4.Department of Preventive MedicineSeoul National University College of MedicineSeoulRepublic of Korea
  5. 5.Department of Obstetrics and Gynecology, School of MedicineEwha Womans UniversitySeoulRepublic of Korea

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