Non-steroidal anti-inflammatory drugs (NSAIDs) and breast cancer risk: differences by molecular subtype
- 313 Downloads
Use of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with reduced risk of breast cancer, though findings have been inconsistent. This inconsistency may result from differences in etiology for breast tumors of different subtypes. We examined the association between NSAID use and breast cancer characterized by molecular subtypes in a population-based case–control study in Western New York. Cases (n = 1,170) were women with incident, primary, histologically confirmed breast cancer. Controls (n = 2,115) were randomly selected from NY Department of Motor Vehicles records (<65 years) or Medicare rolls (≥65 years). Participants answered questions regarding their use of aspirin and ibuprofen in the year prior to interview and their use of aspirin throughout their adult life. Logistic regression models estimated odds ratios (OR) and 95% confidence intervals (95% CI). Recent and lifetime aspirin use was associated with reduced risk, with no differences by subtype. Recent use of ibuprofen was significantly associated with increased risk of ER+/PR+(OR 1.33, 95% CI: 1.09–1.62), HER2− (OR 1.27, 95% CI: 1.05–1.53), and p53− breast cancers (OR 1.28, 95% CI: 1.04–1.57), as well as luminal A or B breast cancers. These findings support the hypothesis of heterogeneous etiologies of breast cancer subtypes and that aspirin and ibuprofen vary in their effects.
KeywordsAspirin Breast cancer HER-2 Hormone receptor Ibuprofen P53 Non-steroidal anti-inflammatory drugs
This work was supported in part by grants DAMD-17-03-1-0446 and DAMD-17-96-1-6202 from the US Department of Defense, and R01-CA92040, P50-AA09802, R25-CA94880, and K05-CA154337 from the National Institutes of Health, National Cancer Institute.
- 20.Ready A, Velicer, CM., McTiernan A, White E (2007) NSAID use and breast cancer risk in the VITAL cohort. Breast Cancer Res Treat. Published Online Aug 3, 2007Google Scholar
- 27.Bardia A, Olson JE, Vachon CM, Lazovich D, Vierkant RA, Wang AH et al (2010) Effect of aspirin and other NSAIDs on postmenopausal breast cancer incidence by hormone receptor status: results from a prospective cohort study. Breast Cancer Res Treat. 2010 Jul 29Google Scholar
- 30.Allred DC, Harvey JM, Berardo M, Clark GM (1998) Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Modern Pathol 11(2):155–168Google Scholar
- 32.Figueroa JD, Terry MB, Gammon MD, Vaughan TL, Risch HA, Zhang F-F et al (2009) Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression. Cancer Causes Control 20(3):361–368PubMedCrossRefGoogle Scholar