Cancer Causes & Control

, 22:965 | Cite as

Non-steroidal anti-inflammatory drugs (NSAIDs) and breast cancer risk: differences by molecular subtype

  • Theodore M. BraskyEmail author
  • Matthew R. Bonner
  • Kirsten B. Moysich
  • Christine B. Ambrosone
  • Jing Nie
  • Meng Hua Tao
  • Stephen B. Edge
  • Bhaskar V. S. Kallakury
  • Catalin Marian
  • David S. Goerlitz
  • Maurizio Trevisan
  • Peter G. Shields
  • Jo L. Freudenheim
Original paper


Use of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with reduced risk of breast cancer, though findings have been inconsistent. This inconsistency may result from differences in etiology for breast tumors of different subtypes. We examined the association between NSAID use and breast cancer characterized by molecular subtypes in a population-based case–control study in Western New York. Cases (n = 1,170) were women with incident, primary, histologically confirmed breast cancer. Controls (n = 2,115) were randomly selected from NY Department of Motor Vehicles records (<65 years) or Medicare rolls (≥65 years). Participants answered questions regarding their use of aspirin and ibuprofen in the year prior to interview and their use of aspirin throughout their adult life. Logistic regression models estimated odds ratios (OR) and 95% confidence intervals (95% CI). Recent and lifetime aspirin use was associated with reduced risk, with no differences by subtype. Recent use of ibuprofen was significantly associated with increased risk of ER+/PR+(OR 1.33, 95% CI: 1.09–1.62), HER2− (OR 1.27, 95% CI: 1.05–1.53), and p53− breast cancers (OR 1.28, 95% CI: 1.04–1.57), as well as luminal A or B breast cancers. These findings support the hypothesis of heterogeneous etiologies of breast cancer subtypes and that aspirin and ibuprofen vary in their effects.


Aspirin Breast cancer HER-2 Hormone receptor Ibuprofen P53 Non-steroidal anti-inflammatory drugs 



This work was supported in part by grants DAMD-17-03-1-0446 and DAMD-17-96-1-6202 from the US Department of Defense, and R01-CA92040, P50-AA09802, R25-CA94880, and K05-CA154337 from the National Institutes of Health, National Cancer Institute.

Supplementary material

10552_2011_9769_MOESM1_ESM.docx (18 kb)
Supplementary material 1 (DOCX 17 kb)


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Theodore M. Brasky
    • 1
    • 6
    Email author
  • Matthew R. Bonner
    • 1
  • Kirsten B. Moysich
    • 2
  • Christine B. Ambrosone
    • 2
  • Jing Nie
    • 1
  • Meng Hua Tao
    • 1
  • Stephen B. Edge
    • 3
  • Bhaskar V. S. Kallakury
    • 4
  • Catalin Marian
    • 4
  • David S. Goerlitz
    • 4
  • Maurizio Trevisan
    • 5
  • Peter G. Shields
    • 4
  • Jo L. Freudenheim
    • 1
  1. 1.Department of Social and Preventive Medicine, School of Public Health and Health ProfessionsUniversity at BuffaloBuffaloUSA
  2. 2.Department of Cancer Prevention and ControlRoswell Park Cancer InstituteBuffaloUSA
  3. 3.Department of Surgical OncologyRoswell Park Cancer InstituteBuffaloUSA
  4. 4.Lombardi Comprehensive Cancer CenterGeorgetown UniversityWashingtonUSA
  5. 5.Nevada System of Higher EducationLas VegasUSA
  6. 6.Fred Hutchinson Cancer Research CenterSeattleUSA

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