Postdiagnosis diet quality, the combination of diet quality and recreational physical activity, and prognosis after early-stage breast cancer
To investigate, among women with breast cancer, how postdiagnosis diet quality and the combination of diet quality and recreational physical activity are associated with prognosis.
This multiethnic, prospective observational cohort included 670 women diagnosed with local or regional breast cancer. Thirty months after diagnosis, women completed self-report assessments on diet and physical activity and were followed for 6 years. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals for death from any cause and breast cancer death.
Women consuming better-quality diets, as defined by higher Healthy Eating Index-2005 scores, had a 60% reduced risk of death from any cause (HRQ4:Q1: 0.40, 95% CI: 0.17, 0.94) and an 88% reduced risk of death from breast cancer (HRQ4:Q1: 0.12, 95% CI: 0.02, 0.99). Compared with inactive survivors consuming poor-quality diets, survivors engaging in any recreational physical activity and consuming better-quality diets had an 89% reduced risk of death from any cause (HR: 0.11, 95% CI: 0.04, 0.36) and a 91% reduced risk of death from breast cancer (HR: 0.09, 95% CI: 0.01, 0.89). Associations observed were independent of obesity status.
Women diagnosed with localized or regional breast cancer may improve prognosis by adopting better-quality dietary patterns and regular recreational physical activity. Lifestyle interventions emphasizing postdiagnosis behavior changes are advisable in breast cancer survivors.
KeywordsDiet Exercise Breast neoplasm Prognosis
- 2.American Cancer Society (2009) Breast cancer facts and figures 2009–2010. Atlanta, GAGoogle Scholar
- 3.Horner M, Ries L, Krapcho M, Neyman N, Aminou R, Howlader N et al (eds) (2009) SEER cancer statistics review, 1975–2006. National Cancer Institute, BethesdaGoogle Scholar
- 19.Bowman SA, Friday JE, Moshfegh A (2008) MyPyramid equivalents database, 2.0 for USDA survey foods, 2003–2004. Food Surveys Research Group. Beltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MDGoogle Scholar
- 20.Guenther PM, Krebs-Smith SM, Reedy J, Britten P, Juan W, Lino M et al (2008) Healthy eating index-2005. Center for Nutrition Policy and Promotion, United States Department of Agriculture, BeltsvilleGoogle Scholar
- 23.Guenther PM, Reedy J, Krebs-Smith SM, Reeve BB, Basiotis PP (2007) Development and evaluation of the healthy eating index-2005: technical report: Center for Nutrition Policy and Promotion, U.S. Department of AgricultureGoogle Scholar
- 24.U.S. Department of Health and Human Services and U.S. Department of Agriculture (2005) Dietary guidelines for Americans, 2005, 6th edn. U.S. Government Printing Office, WashingtonGoogle Scholar
- 25.Kriska A (1997) Modifiable activity questionnaire. Med Sci Sports Exercise 29(6 Supplement):73–78Google Scholar
- 27.U.S. Department of Health and Human Services (2008) Physical activity guidelines for Americans: be active, healthy, and happy. Washington, DCGoogle Scholar
- 33.George SM, Neuhouser ML, Mayne ST, Irwin ML, Albanes D, Gail MH, et al (2010) Postdiagnosis diet quality is inversely related to a biomarker of inflammation among breast cancer survivors. Cancer Epidemiol Biomarkers Prev 19(9):2220–2228Google Scholar
- 36.Guenther PM, Krebs-Smith SM, Reedy J, Britten P, Juan WY, Lino M, et al (2008) Healthy eating index-2005 fact sheet. CNPPFact Sheet No. 1; Dec 2006. Slightly Revised June 2008Google Scholar