Cancer Causes & Control

, Volume 22, Issue 4, pp 589–598 | Cite as

Postdiagnosis diet quality, the combination of diet quality and recreational physical activity, and prognosis after early-stage breast cancer

  • Stephanie M. George
  • Melinda L. Irwin
  • Ashley W. Smith
  • Marian L. Neuhouser
  • Jill Reedy
  • Anne McTiernan
  • Catherine M. Alfano
  • Leslie Bernstein
  • Cornelia M. Ulrich
  • Kathy B. Baumgartner
  • Steven C. Moore
  • Demetrius Albanes
  • Susan T. Mayne
  • Mitchell H. Gail
  • Rachel Ballard-Barbash
Original paper

Abstract

Objective

To investigate, among women with breast cancer, how postdiagnosis diet quality and the combination of diet quality and recreational physical activity are associated with prognosis.

Methods

This multiethnic, prospective observational cohort included 670 women diagnosed with local or regional breast cancer. Thirty months after diagnosis, women completed self-report assessments on diet and physical activity and were followed for 6 years. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals for death from any cause and breast cancer death.

Results

Women consuming better-quality diets, as defined by higher Healthy Eating Index-2005 scores, had a 60% reduced risk of death from any cause (HRQ4:Q1: 0.40, 95% CI: 0.17, 0.94) and an 88% reduced risk of death from breast cancer (HRQ4:Q1: 0.12, 95% CI: 0.02, 0.99). Compared with inactive survivors consuming poor-quality diets, survivors engaging in any recreational physical activity and consuming better-quality diets had an 89% reduced risk of death from any cause (HR: 0.11, 95% CI: 0.04, 0.36) and a 91% reduced risk of death from breast cancer (HR: 0.09, 95% CI: 0.01, 0.89). Associations observed were independent of obesity status.

Conclusion

Women diagnosed with localized or regional breast cancer may improve prognosis by adopting better-quality dietary patterns and regular recreational physical activity. Lifestyle interventions emphasizing postdiagnosis behavior changes are advisable in breast cancer survivors.

Keywords

Diet Exercise Breast neoplasm Prognosis 

Notes

Acknowledgments

We would like to thank Dr. Charles L. Wiggins, HEAL Study managers, Eric Meier of the Fred Hutchinson Cancer Research Center Nutrition Assessment Shared Resource, Todd Gibson of Information Management Systems, and the HEAL Study participants. This study is supported by National Cancer Institute Grants: N01-CN-75036-20, NO1-CN-05228, NO1-PC-67010, and T32 CA105666.

Conflicts of interest

No conflicts of interest or disclaimers to report.

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Copyright information

© Springer Science+Business Media B.V. (outside the USA) 2011

Authors and Affiliations

  • Stephanie M. George
    • 1
    • 2
  • Melinda L. Irwin
    • 2
  • Ashley W. Smith
    • 3
  • Marian L. Neuhouser
    • 4
  • Jill Reedy
    • 3
  • Anne McTiernan
    • 4
  • Catherine M. Alfano
    • 5
  • Leslie Bernstein
    • 6
  • Cornelia M. Ulrich
    • 4
    • 7
  • Kathy B. Baumgartner
    • 8
  • Steven C. Moore
    • 1
  • Demetrius Albanes
    • 1
  • Susan T. Mayne
    • 2
  • Mitchell H. Gail
    • 9
  • Rachel Ballard-Barbash
    • 3
  1. 1.Nutritional Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer InstituteRockvilleUSA
  2. 2.Division of Chronic Disease EpidemiologyYale School of Public HealthNew HavenUSA
  3. 3.Applied Research Program, Division of Cancer Control and Population SciencesNational Cancer InstituteRockvilleUSA
  4. 4.Division of Public Health SciencesFred Hutchinson Cancer Research CenterSeattleUSA
  5. 5.Office of Cancer Survivorship, Division of Cancer Control and Population SciencesNational Cancer InstituteRockvilleUSA
  6. 6.Department of Population SciencesCity of Hope Medical Center and Beckman Research CenterDuarteUSA
  7. 7.German Cancer Research Center and National Center for Tumor DiseasesHeidelbergGermany
  8. 8.Department of Epidemiology and Population HealthUniversity of LouisvilleLouisvilleUSA
  9. 9.Biostatistics Branch, Division of Cancer Epidemiology and GeneticsNational Cancer InstituteRockvilleUSA

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