Maternal consumption of coffee and tea during pregnancy and risk of childhood ALL: results from an Australian case–control study
- 600 Downloads
To investigate whether maternal coffee and/or tea consumption during the last 6 months of pregnancy was associated with risk of childhood ALL.
Data on coffee and tea drinking during pregnancy from 337 case mothers and 697 control mothers were analyzed using unconditional multivariable logistic regression. A meta-analysis of our findings with those of previous studies was also conducted.
There was little evidence of an overall association between maternal coffee consumption and risk of ALL: OR 0.89 (95% CI 0.61, 1.30), although there was some suggestion that higher levels of intake might increase the risk in children of non-smoking mothers: OR for 2+ cups/day = 1.44 (95% CI 0.85, 2.42); this was supported by our meta-analysis. Risk was also elevated among cases with chromosomal translocations. The overall OR for maternal tea consumption was 0.82 (95% CI 0.56, 1.18), although the OR for T-cell ALL was 0.21 (95% CI 0.08, 0.51). Among ALL cases with translocations, the ORs for tea consumption tended to be elevated: OR = 1.70 (95% CI 0.79–3.68) for 2+ cups/day.
The observed increased risk associated with coffee and tea consumption may be confined to ALL with translocations. These associations should be explored further in large international consortia.
KeywordsChild Coffee Diet Leukemia Tea
This was supported by the Australian National Health and Medical Research Council (Grant ID 254539); National Health and Medical Research Council Career Development Award and Cancer Council Western Australia Research Fellowship (to LM); National Health and Medical Research Council PhD Scholarship (to HB); National Health and Medical Research Council Fellowship and Program Grant (to CB); and the Cancer Council Western Australia Usher Vacation Scholarship (to LB).
- 12.Bailey HD, Milne E, de Klerk NH et al (In press) Exposure to house painting and the use of floor treatments and the risk of childhood acute lymphoblastic leukemia. Int J Cancer. doi: 10.1002/ijc.25572
- 14.Bailey HD, Milne E, de Klerk NH et al (In press) Exposure to professional pest control treatments and the risk of childhood acute lymphoblastic leukemia. Int J Cancer. doi: 10.1002/ijc.25769
- 16.Milne E, Royle JA, Miller M et al (2009) Maternal folate and other vitamin supplementation during pregnancy and risk of acute lymphoblastic leukemia in the offspring. Int J Cancer 126:2690–2699Google Scholar
- 21.Australian Bureau of Statistics (2006) Australian social trends (cat. no. 4102.0) Australian Bureau of StatisticsGoogle Scholar
- 32.Food Standards Australia New Zealand (2007) NUTTAB 2006—Australian food composition tables. FSANZ, CanberraGoogle Scholar