Cancer Causes & Control

, Volume 22, Issue 1, pp 81–89 | Cite as

Physical activity and endogenous sex hormones in postmenopausal women: to what extent are observed associations confounded or modified by BMI?

  • Stefanie Liedtke
  • Martina E. Schmidt
  • Susen Becker
  • Rudolf Kaaks
  • Aida Karina Zaineddin
  • Katharina Buck
  • Dieter Flesch-Janys
  • Jürgen Wahrendorf
  • Jenny Chang-Claude
  • Karen Steindorf
Original paper



To investigate associations between physical activity and endogenous sex hormones after menopause with a special focus on confounding and effect modification by body mass index (BMI).


A cross-sectional study among 1,260 postmenopausal women was conducted. Generalized linear models were used to compare levels of total leisure-time physical activity, sports activities, bicycling, and walking with levels of sex hormones and sex-hormone-binding-globulin (SHBG).


Higher sports activity levels were significantly associated with lower levels of estrone and total and free testosterone in multivariate adjusted models. After additional adjustment for BMI, associations with estrone and free testosterone were attenuated; the association with total testosterone remained unchanged. No physical activity variable was significantly related to total and free estradiol, androstenedione, or SHBG. We did not observe effect modification by BMI.


Sports activities may lead to lower levels of estrone and testosterone in postmenopausal women. While effects on estrone and free testosterone seem to be largely mediated by BMI, effects on total testosterone appear to be mainly independent of BMI. The BMI-independent effects on these hormones (especially on total testosterone) could at least partly explain why physical activity has been frequently reported to be preventive for postmenopausal breast cancer, even after accounting for BMI.


Physical activity Sports Sex hormones Postmenopausal women Breast cancer 


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Stefanie Liedtke
    • 1
  • Martina E. Schmidt
    • 1
  • Susen Becker
    • 2
  • Rudolf Kaaks
    • 2
  • Aida Karina Zaineddin
    • 2
  • Katharina Buck
    • 2
  • Dieter Flesch-Janys
    • 3
  • Jürgen Wahrendorf
    • 1
  • Jenny Chang-Claude
    • 2
  • Karen Steindorf
    • 1
  1. 1.Unit of Environmental EpidemiologyGerman Cancer Research Center, Deutsches KrebsforschungszentrumHeidelbergGermany
  2. 2.Division of Cancer EpidemiologyGerman Cancer Research CenterHeidelbergGermany
  3. 3.Department of Medical Biometry and Epidemiology, Center for Experimental MedicineUniversity Medical Center Hamburg-EppendorfHamburgGermany

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