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Cancer Causes & Control

, Volume 21, Issue 12, pp 2295–2302 | Cite as

Alcohol consumption and mortality from all-cause and cancers among 1.34 million Koreans: the results from the Korea national health insurance corporation’s health examinee cohort in 2000

  • Mi Kyung Kim
  • Min Jung Ko
  • Jun Tae Han
Original paper

Abstract

Background

The relationship between alcohol and cancer death has not been well established in Asian population, particularly among women.

Method

We evaluated the association between alcohol consumption and all-cause and cancer mortality in a large-scale prospective study of 1,341,393 Korean men and women aged 40–69 years who participated in health examination in 2000. After 5 years follow-up for mortality (2001–2005), 19,375 deaths were identified, and Cox regression was used for longitudinal analyses.

Results

The J-shaped relationship between alcohol consumption and all-cause and all-cancer mortality was found in men. However, heavy drinking was positively associated with the risk of all-cause and all-cancer mortality in men and women. Alcohol consumption was positively associated with the risk of cancer mortality such as cancers of liver, stomach, colorectal, prostate, esophageal, brain, and larynx and cancer of lips, oral cavity, pharynx in men and increased the risk of all-cancer and colorectal cancer mortality in women. Kidney cancer mortality was inversely associated with alcohol consumption in men.

Conclusion

Heavy drinking showed an increased mortality risk of all-cause, all-cancer, and several cancers in men and women. There was no favorable effect of light drinking on all-cause and all-cancer mortality for women.

Keywords

Alcohol Alcohol consumption Mortality Cancer Asia 

Abbreviations

KNHIC

The Korea national health insurance corporation

HEC2000

Health examinee cohort in 2000

BMI

Body mass index

References

  1. 1.
    Maclure M (1993) Demonstration of deductive meta-analysis: ethanol intake, risk of myocardial infarction. Epidemiol Rev 15:328–351PubMedGoogle Scholar
  2. 2.
    Chick J (1998) Alcohol health, the heart: implications for clinicians. Alcohol Alcohol 33:576–591PubMedGoogle Scholar
  3. 3.
    Estruch R, Sacanella E, Badia E et al (2004) Different effects of red wine, gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of wine on inflammatory markers. Atherosclerosis 175:117–123CrossRefPubMedGoogle Scholar
  4. 4.
    White IR, Altmann DR, Nanchahal K (2002) Alcohol consumption and mortality: modelling risks for men and women at different ages. BMJ 325:191CrossRefPubMedGoogle Scholar
  5. 5.
    Doll R, Peto R, Hall E, Wheatley K, Gray R (1994) Mortality in relation to consumption of alcohol: 13 years’ observations on male British doctors. BMJ 309:911–918PubMedGoogle Scholar
  6. 6.
    Fuchs CS, Stampfer MJ, Colditz GA et al (1995) Alcohol consumption, mortality among women. N Engl J Med 332:1245–1250CrossRefPubMedGoogle Scholar
  7. 7.
    National Institute on Alcohol Abuse, Alcoholism (1995) The physician’s guide to helping patients with alcohol problems. NIAAA, BethesdaGoogle Scholar
  8. 8.
    Campbell NR, Ashley MJ, Carruthers SG, Lacourciere Y, McKay DW (1999) Lifestyle modifications to prevent, control hypertension. 3. Recommendations on alcohol consumption. Canadian hypertension society, Canadian coalition for high blood pressure prevention, control, laboratory centre for disease control at health Canada, heart, stroke foundation of Canada. CMAJ 160:S13–S20PubMedGoogle Scholar
  9. 9.
    Naitonal Health Medical Research Council (2001) Australian alcohol guidelines: health risks and benefits. NHMC/AusInfo, CanberraGoogle Scholar
  10. 10.
    Mukamal KJ, Rimm EB (2008) Alcohol consumption: risks, benefits. Curr Atheroscler Rep 10:536–543CrossRefPubMedGoogle Scholar
  11. 11.
    National Health Insurance Corporation HIRAS (2007) National health insurance statistical yearbook 2008Google Scholar
  12. 12.
    Kwon HJ (ed) (2007) Characteristics and application strategies of census and death certificate data winter symposium, Korean society for preventive medicine, Yonsei University, Seoul, KoreaGoogle Scholar
  13. 13.
    Tobacco smoke and involuntary smoking (2004) IARC Monogr Eval Carcinog Risks Hum. 83:1–1438Google Scholar
  14. 14.
    Durrleman S, Simon R (1989) Flexible regression models with cubic splines. Stat Med 8:551–561CrossRefPubMedGoogle Scholar
  15. 15.
    Govindarajulu US, Spiegelman D, Thurston SW, Ganguli B, Eisen EA (2007) Comparing smoothing techniques in Cox models for exposure-response relationships. Stat Med 26:3735–3752CrossRefPubMedGoogle Scholar
  16. 16.
    Holman CD, English DR, Milne E, Winter MG (1996) Meta-analysis of alcohol and all-cause mortality: a validation of NHMRC recommendations. Med J Aust 164:141–145PubMedGoogle Scholar
  17. 17.
    Freiberg MS, Chang YF, Kraemer KL, Robinson JG, Adams-Campbell LL, Kuller LL (2009) Alcohol consumption, hypertension, and total mortality among women. Am J Hypertens 22:1212–1218CrossRefPubMedGoogle Scholar
  18. 18.
    Bradley KA, Badrinath S, Bush K, Boyd-Wickizer J, Anawalt B (1998) Medical risks for women who drink alcohol. J Gen Intern Med 13:627–639CrossRefPubMedGoogle Scholar
  19. 19.
    Maskarinec G, Meng L, Kolonel LN (1998) Alcohol intake, body weight, mortality in a multiethnic prospective cohort. Epidemiology 9:654–661CrossRefPubMedGoogle Scholar
  20. 20.
    Baraona E, Abittan CS, Dohmen K et al (2001) Gender differences in pharmacokinetics of alcohol. Alcohol Clin Exp Res 25:502–507CrossRefPubMedGoogle Scholar
  21. 21.
    Poschl G, Stickel F, Wang XD, Seitz HK (2004) Alcohol cancer: genetic, nutritional aspects. Proc Nutr Soc 63:65–71CrossRefPubMedGoogle Scholar
  22. 22.
    World Cancer Research Fund/American Institute for Cancer Research (2007). Food, nutrition, physical activity, and the prevention of cancer: a global perspective. WCRF/AICR, Washington, DCGoogle Scholar
  23. 23.
    Burger M, Bronstrup A, Pietrzik K (2004) Derivation of tolerable upper alcohol intake levels in Germany: a systematic review of risks, benefits of moderate alcohol consumption. Prev Med 39:111–127CrossRefPubMedGoogle Scholar
  24. 24.
    Brenner H, Rothenbacher D, Bode G, Adler G (1997) Relation of smoking, alcohol, coffee consumption to active Helicobacter pylori infection: cross sectional study. BMJ 315:1489–1492PubMedGoogle Scholar
  25. 25.
    Sanjoaquin MA, Allen N, Couto E, Roddam AW, Key TJ (2005) Folate intake, colorectal cancer risk: a meta-analytical approach. Int J Cancer 113:825–828CrossRefPubMedGoogle Scholar
  26. 26.
    Druesne-Pecollo N, Tehard B, Mallet Y et al (2009) Alcohol, genetic polymorphisms: effect on risk of alcohol-related cancer. Lancet Oncol 10:173–180CrossRefPubMedGoogle Scholar
  27. 27.
    Eng MY, Luczak SE, Wall TL (2007) ALDH2, ADH1B, ADH1C genotypes in Asians: a literature review. Alcohol Res Health 30:22–27PubMedGoogle Scholar
  28. 28.
    Moskal A, Norat T, Ferrari P, Riboli E (2007) Alcohol intake, colorectal cancer risk: a dose-response meta-analysis of published cohort studies. Int J Cancer 120:664–671CrossRefPubMedGoogle Scholar
  29. 29.
    Mizoue T, Inoue M, Wakai K et al (2008) Alcohol drinking, colorectal cancer in Japanese: a pooled analysis of results from five cohort studies. Am J Epidemiol 167:1397–1406CrossRefPubMedGoogle Scholar
  30. 30.
    Kono S, Ikeda M, Tokudome S, Nishizumi M, Kuratsune M (1987) Cigarette smoking, alcohol, cancer mortality: a cohort study of male Japanese physicians. Jpn J Cancer Res 78:1323–1328PubMedGoogle Scholar
  31. 31.
    Wakai K, Nagata C, Mizoue T et al (2007) Alcohol drinking, lung cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol 37:168–174CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Department of Preventive MedicineHanyang University, College of MedicineSeoulRepublic of Korea
  2. 2.The Institute for National Health InsuranceNational Health Insurance CorporationSeoulKorea

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