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Cancer Causes & Control

, Volume 21, Issue 12, pp 2223–2229 | Cite as

Dietary acrylamide intake and the risk of cancer among Finnish male smokers

  • T. Hirvonen
  • J. Kontto
  • M. Jestoi
  • L. Valsta
  • K. Peltonen
  • P. Pietinen
  • S. M. Virtanen
  • H. Sinkko
  • C. Kronberg-Kippilä
  • D. Albanes
  • J. Virtamo
Original paper

Abstract

Objective

To assess the association between dietary acrylamide intake and the risk of cancer among male smokers.

Methods

The study consisted of 27,111 male smokers, aged 50–69 years, without history of cancer. They were participants of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study in Finland. The men completed a validated dietary questionnaire and a questionnaire on general background characteristics (including smoking habits) at baseline. Incident cases of cancer were identified through the national Finnish Cancer Registry.

Results

During an average 10.2 year follow-up, 1,703 lung cancers, 799 prostate cancers, 365 urothelial cancers, 316 colorectal cancers, 224 stomach cancers, 192 pancreatic cancers, 184 renal cell cancers, and 175 lymphomas were diagnosed. Dietary acrylamide intake was positively associated with the risk of lung cancer; relative risk (RR) in the highest versus the lowest quintile in the multivariable-adjusted model was 1.18 ((95% confidence interval (CI) 1.01–1.38, p for trend 0.11). Other cancers were not associated with acrylamide intake.

Conclusions

High acrylamide intake is associated with increased risk of lung cancer but not with other cancers in male smokers.

Keywords

Acrylamide intake Food Cancer Cohort studies 

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • T. Hirvonen
    • 1
  • J. Kontto
    • 2
  • M. Jestoi
    • 3
  • L. Valsta
    • 4
  • K. Peltonen
    • 3
  • P. Pietinen
    • 2
  • S. M. Virtanen
    • 4
  • H. Sinkko
    • 4
  • C. Kronberg-Kippilä
    • 4
  • D. Albanes
    • 5
  • J. Virtamo
    • 2
  1. 1.Finnish Food Safety Authority, Risk Assessment UnitHelsinkiFinland
  2. 2.National Institute for Health and Welfare (THL), Department of Chronic Disease PreventionHelsinkiFinland
  3. 3.Finnish Food Safety Authority, Research Department, Unit of Chemistry and ToxicologyHelsinkiFinland
  4. 4.National Institute for Health and Welfare (THL), Department of Lifestyle and ParticipationHelsinkiFinland
  5. 5.National Cancer Institute, Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology BranchBethesdaUSA

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