Cancer Causes & Control

, Volume 21, Issue 11, pp 1799–1806

Drinking of maté and the risk of cancers of the upper aerodigestive tract in Latin America: a case–control study

  • K. Szymańska
  • E. Matos
  • R. J. Hung
  • V. Wünsch-Filho
  • J. Eluf-Neto
  • A. Menezes
  • A. W. Daudt
  • P. Brennan
  • P. Boffetta
Original paper

DOI: 10.1007/s10552-010-9606-6

Cite this article as:
Szymańska, K., Matos, E., Hung, R.J. et al. Cancer Causes Control (2010) 21: 1799. doi:10.1007/s10552-010-9606-6

Abstract

Cancers of the upper aerodigestive tract (UADT: oral cavity, oropharynx, hypopharynx, larynx, esophagus) have high incidence rates all over the world and they are especially frequent in some parts of Latin America. In this study, we have evaluated the role of the consumption of maté, a hot herb-based beverage, based on 1168 UADT squamous-cell carcinoma cases and 1,026 frequency-matched controls enrolled from four centers in Brazil and Argentina. The effect of maté drinking on the risk of head-and-neck cancers was borderline significant. A significant effect was observed only for cancer of the esophagus (OR 3.81 (95% CI 1.75–8.30)). While duration of maté drinking was associated with the risk of all UADT cancers, the association with cumulative maté consumption was restricted to esophageal cancer (p-value of linear trend 0.006). The analyses of temperature at which maté was drunk were not conclusive. The increased risk associated with maté drinking was more evident in never-smokers and never-alcohol drinkers than in other individuals. Our study strengthens the evidence of an association between maté drinking and esophageal cancer; the hypothesis of an association with other UADT cancers remains to be clarified.

Keywords

UADT Aerodigestive Upper aerodigestive tract South America Latin America Maté Cancer Risk Case–control study 

Abbreviations

UADT

Upper aerodigestive tract

SCC

Squamous-cell carcinoma

OR

Odds ratio

CI

Confidence interval

AF

Attributable fraction

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • K. Szymańska
    • 1
  • E. Matos
    • 2
  • R. J. Hung
    • 1
    • 3
  • V. Wünsch-Filho
    • 4
  • J. Eluf-Neto
    • 4
  • A. Menezes
    • 5
  • A. W. Daudt
    • 6
  • P. Brennan
    • 1
  • P. Boffetta
    • 1
    • 7
    • 8
  1. 1.International Agency for Research on Cancer (IARC)LyonFrance
  2. 2.University of Buenos AiresBuenos AiresArgentina
  3. 3.Samuel Lunenfeld Research Institute of Mount Sinai HospitalTorontoCanada
  4. 4.Universidade de São PaoloSão PauloBrazil
  5. 5.Federal University of PelotasPelotasBrazil
  6. 6.Clinical Hospital of Porto AlegrePorto AlegreBrazil
  7. 7.The Tisch Cancer Institute, Mount Sinai School of MedicineNew YorkUSA
  8. 8.International Prevention Research InstituteLyonFrance

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